European Journal of Internal Medicine
Volume 15, Issue 2 , Pages 97-107 , April 2004

Experimentally induced prolonged magnesium deficiency causes osteoporosis in the rat

Received 11 March 2003 ,Revised 25 November 2003 ,Accepted 27 November 2003.

References 

  1. Stendig-Lindberg G, Tepper R, Leichter I. Trabecular bone density in a two year controlled trial of peroral magnesium in osteoporosis. Magnes. Res. 1993;6:155–163
  2. Stendig-Lindberg G. Long term oral magnesium treatment in post menopausal osteoporosis. In: Abstracts. Research fair, April 4, 2001, Tel-Aviv University, Tel-Aviv, Israel, Sackler Faculty of Medicine. Medicine for the Golden Age T 8. 2001;p. 348
  3. Tucker KL, Hannan MT, Chen H, Cupples LA, Wilson PWF, Kiel DP. Potassium, magnesium, fruit and vegetable intakes are associated with greater bone mineral density in elderly men and women. Am. J. Clin. Nutr. 1998;69:727–738
  4. Rude RK, Olerich M. Magnesium deficiency: possible role in osteoporosis associated with gluten sensitive enteropathy. Osteoporos. Int. 1996;6:453–461
  5. Rude K, Kirchen ME, Gruber HE, Stasky AA, Meyer MH. Magnesium deficiency induces bone loss in the rat. Miner. Electrolyte Metab. 1998;24:314–320
  6. Rude RK, Kirchen ME, Gruber HE, Meyer MH, Luck JS, Crawford DL. Magnesium-induced osteoporosis in the rat: uncoupling of bone formation and bone resorption. Magnes. Res. 1999;12:257–267
  7. Riond J-L, Hartmann P, Steiner P, Ursprung R, Wanner M, Forrer R, et al.  Long-term excessive magnesium supplementation is deleterious whereas suboptimal supply is beneficial for bones in rats. Magnes. Res. 2000;13:249–264
  8. Moshieff R, Kleiner BY, Leichter I, Chaimsky G, Nyska A, Peyser A, et al.  Use of Dexa to follow mineral contents changes in small ceramic implants in rats. Biomaterials. 1992;13:462–466
  9. Acil Y, Brinckman J, Nothbohm H, Muller K, Batge B. Changes with age in the urinary excretion of hydroxylysylpyridinoline (HP) and lysylpyridinoline (LP). Scand. J. Clin. Lab. Invest. 1996;56:275–283
  10. Vogel M, Hahn M, Delling G. Trabecular bone structure in patients with hyperparathyroidism. Virchows. Archiv. 1995;426:127–134
  11. Hahn M, Vogel M, Pompesius Kempa M, Delling G. Trabecular bone pattern factor—a new parameter for simple quantification of bone microarchitecture. Bone. 1992;13:327–330
  12. Stendig-Lindberg G, Harsat A, Graff E. Magnesium content of mononuclear cells, erythrocytes and 24-hour urine in carefully screened apparently healthy Israelis. Eur. J. Clin. Chem. Clin. Biochem. 1991;29:833–835
  13. Sjogren A, Floren C-H, Nilsson A. Magnesium and potassium status in healthy subjects as assessed by analysis of magnesium and potassium in skeletal muscle biopsies and magnesium in mononuclear cells. Magnesium. 1987;6:91–99
  14. Rude RK, Gruber HE, Wei LY, Frausto A, Mills BG. Magnesium deficiency: effect on bone and mineral metabolism in the mouse. Calcif. Tissue. 2003;72:32–41
  15. Heaton FW. Magnesium relations with parathyroid hormone, calcitonin and bone. Magnes.-Bull. 1981;3:67–72
  16. Stendig-Lindberg G, Bergstrom J, Hultman E. Hypomagnesaemia and muscle electrolytes and metabolites. Acta Med. Scand. 1977;201:273–280
  17. Durlach J. Magnesium in clinical practice. London: John Libbey; 1988;

PII: S0953-6205(04)00006-8

doi: 10.1016/j.ejim.2004.01.003

European Journal of Internal Medicine
Volume 15, Issue 2 , Pages 97-107 , April 2004

Article Tools

* Image Usage & Resolution