European Journal of Internal Medicine
Volume 15, Issue 2 , Pages 121-124, April 2004

Lymphocytic hypophysitis with lachrymal, salivary and thyroid gland involvement

  • Olivier Lidove

      Affiliations

    • Internal Medicine Unit, Internal Medicine, Bichat Hospital, 46 rue Henri Huchard, 75877 Paris cedex 18, France
    • ,
  • Jean-Charles Piette

      Affiliations

    • Internal Medicine Department, Pitié-Salpêtrière Hospital, 83 Boulevard de l'hôpital, 75651 Paris cedex 13, France
    • ,
  • Frédéric Charlotte

      Affiliations

    • Pathology Department, Pitié-Salpêtrière Hospital, 83 Boulevard de l'hôpital, 75651 Paris cedex 13, France
    • ,
  • Nathalie Cassoux

      Affiliations

    • Ophthalmology Department, Pitié-Salpêtrière Hospital, 83 Boulevard de l'hôpital, 75651 Paris cedex 13, France
    • ,
  • Jean-Michel Correas

      Affiliations

    • Radiology Department, Necker Hospital 149 rue de Sèvres, 75743 Paris cedex 15, France
    • ,
  • Thomas Papo

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel.: +33-1-40-25-70-03; fax: +33-1-40-25-88-45.
    • Internal Medicine Unit, Internal Medicine, Bichat Hospital, 46 rue Henri Huchard, 75877 Paris cedex 18, France

Received 14 August 2003; received in revised form 11 November 2003; accepted 25 November 2003.

Abstract 

We report on hypophysitis associated with a prominent lymphoid infiltration of salivary and lachrymal glands in a 35-year-old woman with a dramatic response to steroids. Four years later, overt Graves' disease developed. To our knowledge, pseudotumoral lymphocytic infiltration of both lachrymal and salivary glands has never been described in association with hypophysitis. Benign lymphocytic hypophysitis may belong to a spectrum that extends from low-grade lymphoid proliferation to autoimmune disease. Such a process may follow a regional tissue distribution including pituitary, thyroid, lachrymal and salivary glands.

Keywords:  Hypophysitis, Graves' disease, Salivary gland, Lachrymal gland

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PII: S0953-6205(04)00009-3

doi:10.1016/j.ejim.2004.01.005

European Journal of Internal Medicine
Volume 15, Issue 2 , Pages 121-124, April 2004

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