European Journal of Internal Medicine
Volume 16, Issue 8 , Pages 598-600, December 2005

Latent acute promyelocytic leukemia t(15;17)(q22;q12–21) and sarcoidosis: Long-term cohabitation

  • V. Leymarie

      Affiliations

    • Laboratory of Hematology, Hautepierre University Hospital, avenue Moliere, F-67098 Strasbourg Cedex, France
    • Corresponding Author InformationCorresponding auhtor. Tel.: +33 0388127527; fax: +33 0388127551.
    • ,
  • A.C. Galoisy

      Affiliations

    • Laboratory of Hematology, Hautepierre University Hospital, avenue Moliere, F-67098 Strasbourg Cedex, France
    • ,
  • A. Falkenrodt

      Affiliations

    • Laboratory of Hematology, Hautepierre University Hospital, avenue Moliere, F-67098 Strasbourg Cedex, France
    • ,
  • S. Natarajan-Ame

      Affiliations

    • Department of Hematology and Oncology, Hautepierre University Hospital, Strasbourg, France
    • ,
  • P. Dufour

      Affiliations

    • Department of Hematology and Oncology, Hautepierre University Hospital, Strasbourg, France
    • ,
  • M. Lessard

      Affiliations

    • Laboratory of Hematology, Hautepierre University Hospital, avenue Moliere, F-67098 Strasbourg Cedex, France

Received 22 November 2004; received in revised form 31 March 2005; accepted 1 April 2005.

Abstract 

The association of sarcoidosis with hematological malignancies is a well-known phenomenon. To our knowledge, we report the first case involving sarcoidosis and acute promyelocytic leukemia (APL) t(15;17)(q22;q12–21). The major interest lies in the chronology of the two diseases: the APL demonstrated an unusual smoldering evolution, suggesting that pre-existing sarcoidosis may have a non-fortuitous immunological impact on leukemic clone proliferation.

Keywords: Sarcoidosis, Latent leukemia, Promyelocytic leukemia, t(15;17)(q22;q12–21)

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PII: S0953-6205(05)00278-5

doi:10.1016/j.ejim.2005.04.009

European Journal of Internal Medicine
Volume 16, Issue 8 , Pages 598-600, December 2005

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