European Journal of Internal Medicine
Volume 17, Issue 7 , Pages 508-510 , November 2006

Budesonide combined with ursodeoxycholic acid in primary biliary cirrhosis with advanced liver damage

  • B. Pagán

      Affiliations

    • Medicine Department, University Hospital La Paz, P° Castellana 261, 280046, Madrid, Spain
    • Corresponding Author InformationCorresponding author. La Paz University Hospital, Internal Medicine Department, P° Castellana 261, E-280046 Madrid, Spain. Tel.: +34 649 48 46 91.
    • ,
  • J.C. Erdozain

      Affiliations

    • Gastroenterology Department, University Hospital La Paz, P° Castellana 261, 280046, Madrid, Spain
    • ,
  • C. Comas

      Affiliations

    • Gastroenterology Department, University Hospital La Paz, P° Castellana 261, 280046, Madrid, Spain
    • ,
  • S. Martín-Chávarri

      Affiliations

    • Gastroenterology Department, University Hospital La Paz, P° Castellana 261, 280046, Madrid, Spain
    • ,
  • M. López

      Affiliations

    • Medicine Department, University Hospital La Paz, P° Castellana 261, 280046, Madrid, Spain
    • ,
  • J.F. Gómez-Cerezo

      Affiliations

    • Medicine Department, University Hospital La Paz, P° Castellana 261, 280046, Madrid, Spain

Received 2 November 2005 ,Revised 3 April 2006 ,Accepted 27 April 2006.

References 

  1. Talwalkar JA, Lindor KD. Primary biliary cirrhosis. Lancet. 2003;362:53–61
  2. Vleggaar FP, van Buuren HR, Zondervan PE, ten Kate FJW, Hop WCJ. Jaundice in non-cirrhotic primary biliary cirrhosis: the premature ductopenic variant. Gut. 2001;49:276–281
  3. Levy C, Lindor KD. Current management of primary biliary cirrhosis and primary sclerosing cholangitis. J Hepatol. 2003;38:S24–S37
  4. Angulo P, Jorgensen RA, Keach JC, Dickson ED, Smith C, Lindor KD. Oral budesonide in the treatment of patients with primary biliary cirrhosis with a suboptimal response to ursodeoxycholic acid. Hepatology. 2000;31:318–323
  5. Leuschner M, Maier KP, Schilichting J, Strahl S, Herrmann G, Dahm HH, et al. Oral budesonide and ursodeoxycholic acid for treatment of pirmay biliary cirrrhosis: results of a prospective double-blind trial. Gastroenterology. 1999;117:918–925
  6. Rautiainen H, Karkkainen P, Karvonen AL, Nurmi H, Pikkarainen P, Nuutinen H, et al. Budesonide combined with UDCA to improve liver histology in primary biliary cirrhosis: a three-year randomized trial. Hepatology. Apr 2005;41:747–752
  7. Poupon RE, Lindor KD, Cach-Dudek K, Dickson ER, Poupon R, Heathcote EJ. Combined analysis of randomized controled trials of ursodeoxycholic acid in Primary Biliary Cirrhosis. Gastroenterology. 1997;113:884–890

PII: S0953-6205(06)00166-X

doi: 10.1016/j.ejim.2006.04.006

European Journal of Internal Medicine
Volume 17, Issue 7 , Pages 508-510 , November 2006

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