European Journal of Internal Medicine
Volume 18, Issue 3 , Pages 193-195 , May 2007

Circulating vascular endothelial growth factor is unaffected by acute hyperglycemia and hyperinsulinemia in type 1 diabetes mellitus

Received 20 March 2006 ,Revised 4 September 2006 ,Accepted 2 November 2006.

References 

  1. Aiello LP, Wong JS. Role of vascular endothelial growth factor in diabetic vascular complications. Kidney Int. 2000;58(Suppl 77):S113–S119
  2. Flyvbjerg A, Khatir DS, Jensen LJN, Dagnaes-Hansen F, Gronbaek H, Rasch R. The involvement of growth hormone (GH), insulin-like growth factors (IGFs) and vascular endothelial growth factor (VEGF) in diabetic kidney disease. Curr Pharm Des. 2004;10:3385–3394
  3. Chiarelli F, Spagnoli A, Basciani F, Tumini S, Mezzetti A, Cipollone F, et al. Vascular endothelial growth factor (VEGF) in children, adolescents and young adults with type 1 diabetes mellitus: relation to glycaemic control and microvascular complications. Diabet Med. 2000;17:650–656
  4. Kakizawa H, Itoh M, Itoh Y, Imamura S, Ishiwata Y, Matsumoto T, et al. The relationship between glycemic control and plasma vascular endothelial growth factor and endothelin-1 concentration in diabetic patients. Metabolism. 2004;53:550–555
  5. Santilli F, Spagnoli A, Mohn A, Tumini S, Verrotti A, Cipollone F, et al. Increased vascular endothelial growth factor serum concentrations may help to identify patients with onset of type 1 diabetes during childhood at risk for developing persistent microalbuminuria. J Clin Endocrinol Metab. 2001;86:3871–3876
  6. Seckin D, Ilhan N, Ilhan N, Erdogan S. Glycaemic control, markers of endothelial cell activation and oxidative stress in children with type 1 diabetes mellitus. Diabetes Res Clin Pract. 2006;73:191–197
  7. Ashraf A, Mick G, Meleth S, Abdullatif H, Wang X, McCormick K. Effect of insulin on plasma vascular endothelial growth factor in children with new-onset diabetes. J Clin Endocrinol Metab. 2005;90:4920–4923
  8. Sörensen VR, Mathiesen ER, Clausen P, Flyvbjerg A, Feldt-Rasmussen B. Impaired vascular function during short-term glycaemic control in type 1 diabetic patients. Diab Med. 2005;22:871–876
  9. Dorozo G, Russo I, Mattiello L, Anfossi G, Bosia A, Trovati M. Insulin activates vascular endothelial growth factor in vascular smooth muscle cells: influence of nitric oxide and of insulin resistance. Eur J Clin Investig. 2004;34:664–673
  10. Dandona P, Aljada A, Mohanty P, Ghanim H, Bandyopadhyay A, Chaudhuri A. Insulin suppresses plasma concentration of vascular endothelial growth factor and matrix metalloproteinase-9. Diabetes Care. 2003;26:3310–3314
  11. Stehouwer CDA, Lambert J, Donker AJM, Van Hinsbergh VWM. Endothelial dysfunction and pathogenesis of diabetic angiopathy. Cardiovasc Res. 1997;34:55–68
  12. Blann AD, Lip GYH. Cell adhesion molecules in cardiovascular disease and its risk factors—what can soluble levels tell us?. J Clin Endocrinol Metab. 2000;85:1745–1747
  13. Jilma B, Dallinger S, Hergovich N, Eichler HG, Richter V, Wagner OF. Effects of hyperinsulinemia on plasma levels of circulating adhesion molecules. J Clin Endorinol Metab. 2000;85:1748–17451
  14. Oomen PHN, Kant GD, Dullaart RPF, Tervaert JW, Reitsma WD, Smit AJ. No effects of acute hyperglycaemia and hyperinsulinaemia on skin microcirculation and endothelial markers in Type II diabetes mellitus. Scand J Clin Lab Invest. 2004;64:119–127
  15. Coppola L, Coppola A, Grassia AS, Mastrolorenzo L, Lettieri B, De Lucia D, et al. Acute hyperglycemia alters von Willebrand factor but not the fibrinolytic system in elderly subjects with normal or impaired glucose tolerance. Blood Coagul Fibrinolysis. 2004;15:629–635
  16. Ceriello A, Falleti E, Motz E, Taboga C, Tonutti L, Ezsol Z, et al. Hyperglycemia-induced circulating ICAM-1 increase in diabetes mellitus: the possible role of oxidative stress. Horm Metab Res. 1998;30:146–149
  17. Sampson MJ, Davies IR, Brown JC, Hughes DA. Monocyte and neutrophil adhesion molecule expression during acute hyperglycemia and after antioxidant treatment in type 2 diabetes and control patients. Arterioscler Thromb Vasc Biol. 2002;22:1187–1193

PII: S0953-6205(07)00012-X

doi: 10.1016/j.ejim.2006.11.006

European Journal of Internal Medicine
Volume 18, Issue 3 , Pages 193-195 , May 2007

Article Tools