Chemokines and left ventricular function in patients with acute myocardial infarction

Kobusiak-Prokopowicz, Małgorzata; Orzeszko, Jacek; Mazur, Grzegorz; Mysiak, Andrzej; Orda, Alina; Poreba, Rafal; Mazurek, Walentyna

doi:10.1016/j.ejim.2007.02.001

« Previous Next »European Journal of Internal Medicine
Volume 18, Issue 4 , Pages 288-294, July 2007

Chemokines and left ventricular function in patients with acute myocardial infarction

Małgorzata Kobusiak-Prokopowicz
- Department of Cardiology Wroclaw Medical University, 50-367 Wroclaw, Pasteur 4 Str., Poland
- Corresponding author. Samotna 25 Street, 54–058 Wroclaw, Poland. Tel.: +48 71 784 26 11, +48 609 489 699; fax: +48 71 327 09 61.
Jacek Orzeszko
- Department of Cardiology Wroclaw Medical University, 50-367 Wroclaw, Pasteur 4 Str., Poland
Grzegorz Mazur
- Department of Haematology, Blood Neoplasms and Bone Marrow Transplantation Wroclaw Medical University, 50-367 Wroclaw, Pasteur 4 Str., Poland
Andrzej Mysiak
- Department of Cardiology Wroclaw Medical University, 50-367 Wroclaw, Pasteur 4 Str., Poland
Alina Orda
- Department of Cardiology Wroclaw Medical University, 50-367 Wroclaw, Pasteur 4 Str., Poland
Rafal Poreba
- Department of Internal Medicine, Occupational Disease and Hypertension Wroclaw Medical University, 50-367 Wroclaw, Pasteur 4 Str., Poland
Walentyna Mazurek
- Department of Cardiology Wroclaw Medical University, 50-367 Wroclaw, Pasteur 4 Str., Poland

Received 23 November 2005; received in revised form 10 November 2006; accepted 9 February 2007.

Abstract

Background

Leukocytes are activated in the inflammatory process involving locally atherosclerotic lesions through adhesive molecules attaching to the surface of endothelial cells, especially during acute myocardial infarction. The aim of the study was to assess MCP-1, MIP-1α, and RANTES serum levels in patients with STEMI and to correlate them with the severity of left ventricle (LV) dysfunction.

Methods

Forty patients were initially divided into two groups, with group 1 having an ejection fraction (EF) above 40% and group 2 an EF of 40% or less. Next, the patients were divided on the basis of wall motion score index (WMSI): group 3 had a WMSI of 1.3 or lower and group 4 had a WMSI above 1.3. A control group of ten volunteers was also included in the study. Serum samples were taken at admission as well as 3, 24, 48, 72 h, and 7 days after.

Results

The baseline serum levels of MCP-1 and RANTES in group 1 were significantly higher than in the controls (p<0.05 and p<0.005, respectively). The highest concentrations of chemokines were observed 3 h after admission. The serum levels of MIP-1α on admission and 3 h later were significantly higher in group 1 than in group 2 (p<0.03 and p<0.01, respectively). Maximum MIP-1 concentrations were observed 3 h after admission in group 3 and 24 h after admission in group 4 (p<0.006). In group 1, MIP-1α 3 h after admission correlated positively with the EF (r=0.444, p<0.05). In group 1 there was a negative correlation between MIP-1α concentration 3 h after admission and LV end-diastolic dimension (r=−0.492, p<0.02).