European Journal of Internal Medicine
Volume 18, Issue 4 , Pages 299-303 , July 2007

Aspirin esterase activity — Evidence for skewed distribution in healthy volunteers

  • G.I. Adebayo

      Affiliations

    • Department of Medicine, Sligo General Hospital, The Mall, Sligo, Ireland
    • Corresponding Author InformationCorresponding author.
  • ,
  • J. Williams

      Affiliations

    • Department of Biochemistry, Sligo General Hospital, The Mall, Sligo, Ireland
  • ,
  • S. Healy

      Affiliations

    • Department of Medicine, Sligo General Hospital, The Mall, Sligo, Ireland

Received 13 February 2006 ,Revised 26 June 2006 ,Accepted 14 December 2006.

References 

  1. Schror K. Aspirin and platelets: the antiplatelet action of aspirin and its role in thrombosis treatment and prophylaxis. Semin Thromb Hemost. 1997;23:349–356
  2. Schror K. Antiplatelets drugs. A comparative review. Drugs. 1995;50:7–28
  3. Peto R, Gray R, Collins R, Wheatley K, Hennekens C, Jamrozik K, et al. Randomised trial of prophylactic daily aspirin in British male doctors. Br Med J (Clin Res Ed). 1988;296:313–316
  4. Steering Committee of the Physicians' Health Study Research Group. Final report on the aspirin component of the ongoing Physicians' Health Study. N Engl J Med. 1989;321:129–135
  5. Collaborative Group of the Primary Prevention Project. Low-dose aspirin and vitamin E in people at cardiovascular risk: a randomised trial in general practice. Lancet. 2001;357:89–95
  6. Hansson L, Zanchetti A, Carruthers SG, et al. Effect of intensive blood pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial. HOT Study Group. Lancet. 1998;351:1755–1762
  7. The Medical Research Council's General Practice Research Framework . Thrombosis prevention trial: randomised trial of low-intensity oral anticoagulation with warfarin and low-dose aspirin in the primary prevention of ischaemic heart disease in men at risk. Lancet. 1998;351:233–241
  8. Patrono C, Coller B, Dalen JE, et al. Platelet-active drugs: the relationships among dose, effectiveness, and side effects. Chest. 2004;119:39S–63S[Suppl]
  9. Adebayo GI, William J, Healy S. Pseudocholinesterase polymorphism in Irish population. Eur J Intern Med. 2005;16:492–495
  10. Williams FM, Wynne H, Woodhouse KW, Rawlins MD. Plasma aspirin esterase: the influence of old age and frailty. Age Ageing. 1989;18:39–42
  11. Rainsford KD, Ford NLV, Brooks PM, Watson HM. Plasma aspirin esterase in normal individuals, patients with alcoholic liver disease and rheumatoid arthritis: characterisation and importance of the enzyme components. Eur J Clin Invest. 1980;10:413–420
  12. Dietz AA, Rubinstein HM, Lubrano T. Colorimetric determination of serum cholinesterase and its genetic variants by propionylthiocholine-dithiobis(nitrobenzoic acid) procedure. Sel. Methods Clin. Chem. 1973;19:1309–1313
  13. Menguy R, Desbaillets L, Masters YF, Okabe S. Evidence for a sex-linked difference in aspirin metabolism. Nature. 1972;239:102–103
  14. Khaled Abou-Hatab M, O'Mahony S, Patel S, Woodhouse K. Relationship between age and plasma esterases. Age Ageing. 2001;30:41–45
  15. Rubinstein HM, Dietz AA, Lubrano T. E1k, another qualitative variant at cholinesterase locus 1. J Med Genet. 1978;15:27–29
  16. Evans RT, Wardell J. On the identification and frequency of the J and K cholinesterase phenotypes in a Caucasian population. J Med Genet. 1984;21:99–102
  17. Williams FM, Nicholson EN, Woolhouse NW, Adjepon-Yamoah KK, Rawlins MD. Activity of esterases in plasma from Ghanaian and British subjects. Eur J Clin Pharmacol. 1986;31:485–489
  18. Pedersen AK, Fitzgerald GA. Dose-related kinetics of aspirin presystemic acetylation of platelet cyclooxygenase. N Engl J Med. 1984;311:1206–1211
  19. Gawaz M. In: Blood Platelets. Stuttgart: Georg Thieme Verlag; 2001;p. 57–84
  20. Weber A-A, Przytulski B, Schanz A, Hohlfeld T, Schror K. Towards a definition of aspirin resistance: a typological approach. Platelets. 2002;13:37–40
  21. Benedek IH, Joshi AS, Pieniaszek HJ, King SY, Kornhauser DM. Variability in the pharmacokinetics and pharmacodynamics of low dose aspirin in healthy male volunteers. J Clin Pharmacol. 1995;35:1181–1186
  22. Mueller MR, Salat A, Stangl P, Murabito M, Pulaki S, Boehm D, et al. Variable platelet response to low-dose ASA and the risk of limb deterioration in patients submitted to peripheral arterial angioplasty. Thromb Haemost. 1997;78:1003–1007

PII: S0953-6205(07)00053-2

doi: 10.1016/j.ejim.2006.12.004

European Journal of Internal Medicine
Volume 18, Issue 4 , Pages 299-303 , July 2007