European Journal of Internal Medicine
Volume 18, Issue 4 , Pages 314-320 , July 2007

Anti- and pro-oxidant factors and endothelial dysfunction in chronic cigarette smokers with coronary heart disease

  • E. Rocchi

      Affiliations

    • Dept. Medicine e Specialità Mediche, Chair of Terapia Medica, Università di Modena e Reggio Emilia, Italy
    • Corresponding Author InformationCorresponding author. University of Modena and Reggio Emilia, Dept. Medicine e Specialità Mediche, Chair of Terapia Medica, Via del Pozzo 71, Policlinico di Modena, Italy. Tel.: +39 059 4222151; fax: +39 059 4224363.
    • ,
  • F. Bursi

      Affiliations

    • Dept. Emergenza-Urgenza, Chair of Cardiologia, Università di Modena e Reggio Emilia, Italy
    • ,
  • P. Ventura

      Affiliations

    • Dept. Medicine e Specialità Mediche, Chair of Medicina II, Università di Modena e Reggio Emilia, Italy
    • ,
  • A. Ronzoni

      Affiliations

    • Dept. Medicine e Specialità Mediche, Chair of Terapia Medica, Università di Modena e Reggio Emilia, Italy
    • ,
  • C. Gozzi

      Affiliations

    • Dept. Medicine e Specialità Mediche, Chair of Terapia Medica, Università di Modena e Reggio Emilia, Italy
    • ,
  • G. Casalgrandi

      Affiliations

    • Dept. Medicine e Specialità Mediche, Chair of Terapia Medica, Università di Modena e Reggio Emilia, Italy
    • ,
  • L. Marri

      Affiliations

    • Dept. Medicine e Specialità Mediche, Chair of Terapia Medica, Università di Modena e Reggio Emilia, Italy
    • ,
  • R. Rossi

      Affiliations

    • Dept. Medicine e Specialità Mediche, Chair of Terapia Medica, Università di Modena e Reggio Emilia, Italy
    • ,
  • M.G. Modena

      Affiliations

    • Dept. Medicine e Specialità Mediche, Chair of Terapia Medica, Università di Modena e Reggio Emilia, Italy

Received 22 April 2006 ,Revised 18 September 2006 ,Accepted 12 October 2006.

References 

  1. Lakier JB. Smoking and cardiovascular disease. Am J Med. 1992;93:8S–12S
  2. Neunteufl T, Heher S, Kostner K, Mitulovic G, Lehr S, Khoschsorur G, et al. Contribution of nicotine to acute endothelial dysfunction in long-term smokers. J Am Coll Cardiol. 2002;39:251–256
  3. Zeiher AM, Schachinger V, Minners J. Long-term cigarette smoking impairs endothelium-dependent coronary arterial vasodilator function. Circulation. 1995;92:1094–1100
  4. Celermajer DS, Sorensen KE, Georgakopoulos D, Bull C, Thomas O, Robinson J, et al. Cigarette smoking is associated with dose-related and potentially reversible impairment of endothelium-dependent dilation in healthy young adults. Circulation. 1993;88:2149–2155
  5. Lekakis J, Papamichael C, Vemmos C, Nanas J, Kontoyannis D, Stamatelopoulos S, et al. Effect of acute cigarette smoking on endothelium-dependent brachial artery dilatation in healthy individuals. Am J Cardiol. 1997;79:529–531
  6. Panza JA, Garcia CE, Kilcoyne CM, Quyyumi AA, Cannon RO. Impaired endothelium-dependent vasodilation in patients with essential hypertension. Evidence that nitric oxide abnormality is not localized to a single signal transduction pathway. Circulation. 1995;91:1732–1738
  7. Maxwell SR, Lip GY. Free radicals and antioxidants in cardiovascular disease. Br J Clin Pharmacol. 1997;44:307–317
  8. Nishizawa M, Kohno M, Nishimura M, Kitagawa A, Niwano Y. Presence of peroxyradicals in cigarette smoke and the scavenging effect of shikonin, a naphtoquinone pigment. Chem Pharm Bull. 2005;53:796–799
  9. Fukaya Y, Ohhashi T. Acetylcholine- and flow-induced production and release of nitric oxide in arterial and venous endothelial cells. Am J Physiol. 1996;270:H99–H106
  10. Furchgott RF, Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature. 1980;288:373–376
  11. Joannides R, Haefeli WE, Linder L, Richard V, Bakkali EH, Thuillez C, et al. Nitric oxide is responsible for flow-dependent dilatation of human peripheral conduit arteries in vivo. Circulation. 1995;91:1314–1319
  12. Gilligan DM, Panza JA, Kilcoyne CM, Waclawiw MA, Casino PR, Quyyumi AA. Contribution of endothelium-derived nitric oxide to exercise-induced vasodilation. Circulation. 1994;90:2853–2858
  13. Ignarro LJ, Gruetter CA. Requirement of thiols for activation of coronary arterial guanylate cyclase by glyceryl trinitrate and sodium nitrite: possible involvement of S-nitrosothiols. Biochim Biophys Acta. 1980;631:221–231
  14. Upchurch GR, Welch GN, Loscalzo J. The vascular biology of S-nitrosothiols, nitrosated derivatives of thiols. Vasc Med. 1996;1:25–33
  15. Jaimes EA, DeMaster EG, Tian RX, Raij L. Stable compounds of cigarette smoke induce endothelial superoxide anion production via NADP oxidase activation. Arterioscler Thromb Vasc Biol. 2004;24:1031–1036
  16. Stamler JS, Slivka A. Biological chemistry of thiols in the vasculature and in vascular-related disease. Nutr Rev. 1996;54:1–30
  17. Desideri G, Marinucci MC, Tomassoni G, Masci PG, Santucci A, Ferri C. Vitamin E supplementation reduces plasma vascular cell adhesion molecule-1 and von Willebrand factor levels and increases nitric oxide concentrations in hypercholesterolemic patients. J Clin Endocrinol Metab. 2002;87:2940–2945
  18. Desideri G, Croce G, Marinucci MC, Masci PG, Stati M, Valeri L, et al. Prolonged, low dose alpha-tocopherol therapy counteracts intercellular cell adhesion molecule-1 activation. Clin Chim Acta. 2002;320:5–9
  19. Cassone Faldetta M, Laurenti O, Desideri G, Bravi MC, De Luca O, Marinucci MC, et al. l-arginine infusion decreases plasma total homocysteine concentrations through increased nitric oxide production and decreased oxidative status in Type II diabetic patients. Diabetologia. 2002;45:1120–1127
  20. Heitzer T, Meinertz T. Rauchen und koronare herzkrnakheit. Z Kardiol. 2005;94(3):30–42
  21. Modena MG, Bonetti L, Coppi F, Bursi F, Rossi R. Prognostic role of reversible endothelial dysfunction in hypertensive postmenopausal women. J Am Coll Cardiol. 2002;40:505–510
  22. Vogel RA. Coronary risk factors, endothelial function, and atherosclerosis: a review. Clin Cardiol. 1997;20:426–432
  23. Speek AJ, Schrijver J, Schreurs WH. Fluorometric determination of total vitamin C in whole blood by high-performance liquid chromatography with pre-column derivatization. J Chromatogr. 1984;305:53–60
  24. Rocchi E, Borghi A, Paolillo F, Pradelli M, Casalgrandi G. Carotenoids and liposoluble vitamins in liver cirrhosis. J Lab Clin Med. 1991;118:176–185
  25. Green LC, Wagner DA, Glogowski J, Skipper PL, Wishnok JS, Tannenbaum SR. Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. Anal Biochem. 1982;126:131–138
  26. Morrow JD, Harris TM, Roberts LJ. Noncyclooxygenase oxidative formation of a series of novel prostaglandins: analytical ramifications for measurement of eicosanoids. Anal Biochem. 1990;184:1–10
  27. Morrow JD, Roberts LJ. The isoprostanes: unique bioactive products of lipid peroxidation. Prog Lipid Res. 1997;36:1–21
  28. Morrow JD, Zackert WE, Yang JP, Kurhts EH, Callewaert D, Dworski R, et al. Quantification of the major urinary metabolite of 15-F2t-isoprostane (8-iso-PGF2alpha) by a stable isotope dilution mass spectrometric assay. Anal Biochem. 1999;269:326–331
  29. Wang Z, Ciabattoni G, Creminon C, Lawson J, Fitzgerald GA, Patrono C, et al. Immunological characterization of urinary 8-epi-prostaglandin F2 alpha excretion in man. J Pharmacol Exp Ther. 1995;275:94–100
  30. Roberts LJ, Morrow JD. Measurement of F(2)-isoprostanes as an index of oxidative stress in vivo. Free Radic Biol Med. 2000;28:505–513
  31. Marangon K, O'Byrne D, Devaraj S, Jialal I. Validation of an immunoassay for measurement of plasma total homocysteine. Am J Clin Pathol. 1999;112:757–762
  32. Schwedhelm E, Bartling A, Lenzen H, Tsikas D, Maas R, Brummer J, et al. Urinary 8-iso-prostaglandin F2 alpha as a risk marker in patients with coronary heart disease: a matched case–control study. Circulation. 2004;109(7):843–848
  33. O'Callaghan P, Meleady R, Fitzgerald T, Graham I. Smoking and plasma homocysteine. Eur Heart J. 2002;23:1580–1586
  34. Wilcken DE. Homocysteine, smoking and vascular disease. Eur Heart J. 2002;23:1559–1560
  35. Clarke R, Daly L, Robinson K, Naughten E, Cahalane S, Fowler B, et al. Hyperhomocysteinemia: an independent risk factor for vascular disease. N Engl J Med. 1991;324:1149–1155
  36. Refsum H, Ueland PM, Nygard O, Vollset SE. Homocysteine and cardiovascular disease. Annu Rev Med. 1998;49:31–62
  37. Ozerol E, Ozerol I, Gokdeniz R, Temel I, Akyol O. Effect of smoking on serum concentrations of total homocysteine, folate, vitamin b(12), and nitric oxide in pregnancy: a preliminary study. Fetal Diagn Ther. 2004;19:145–148
  38. Ventura P, Panini R, Verlato C, Scarpetta G, Salvioli G. Peroxidation indices and total antioxidant capacity in plasma during hyperhomocysteinemia induced by methionine oral loading. Metabolism. 2000;49:225–228
  39. Rocchi E, Casalgrandi G, Ronzoni A, Rosa MC, Cioni G, Marazzi A, et al. Antioxidant liposoluble vitamins and carotenoids in chronic hepatitis. Eur J Int Med. 2001;12:116–121
  40. Heitzer T, Just H, Munzel T. Antioxidant vitamin C improves endothelial dysfunction in chronic smokers. Circulation. 1996;94:6–9
  41. Kinlay S, Fang JC, Hikita H, Ho I, Delagrange DM, Frei B, et al. Plasma alpha-tocopherol and coronary endothelium-dependent vasodilator function. Circulation. 1999;100:219–221
  42. Parola M, Leonarduzzi G, Biasi F, Albano E, Biocca ME, Poli G, et al. Vitamin E dietary supplementation protects against carbon tetrachloride-induced chronic liver damage and cirrhosis. Hepatology. 1992;16:1014–1021
  43. Boger RH, Bode-Boger SM, Phivthong-ngam L, Brandes RP, Schwedhelm E, Mugge A, et al. Dietary l-arginine and alpha-tocopherol reduce vascular oxidative stress and preserve endothelial function in hypercholesterolemic rabbits via different mechanisms. Atherosclerosis. 1998;141:31–43
  44. Heitzer T, Yla-Herttuala S, Luoma J, Kurz S, Munzel T, Just H, et al. Cigarette smoking potentiates endothelial dysfunction of forearm resistance vessels in patients with hypercholesterolemia. Role of oxidized LDL. Circulation. 1996;93:1346–1353
  45. Sorensen KE, Celermajer DS, Georgakopoulos D, Hatcher G, Betteridge DJ, Deanfield JE. Impairment of endothelium-dependent dilation is an early event in children with familial hypercholesterolemia and is related to the lipoprotein(a) level. J Clin Invest. 1994;93:50–55
  46. Tonstad S, Refsum H, Ueland PM. Association between plasma total homocysteine and parental history of cardiovascular disease in children with familial hypercholesterolemia. Circulation. 1997;96:1803–1808
  47. Chambers JC, McGregor A, Jean-Marie J, Obeid OA, Kooner JS. Demonstration of rapid onset vascular endothelial dysfunction after hyperhomocysteinemia: an effect reversible with vitamin C therapy. Circulation. 1999;99:1156–1160
  48. Nappo F, De Rosa N, Marfella R, De Lucia D, Ingrosso D, Perna AF, et al. Impairment of endothelial functions by acute hyperhomocysteinemia and reversal by antioxidant vitamins. JAMA. 1999;281:2113–2118

PII: S0953-6205(07)00073-8

doi: 10.1016/j.ejim.2006.10.006

European Journal of Internal Medicine
Volume 18, Issue 4 , Pages 314-320 , July 2007

Article Tools

* Image Usage & Resolution