STAT1 and STAT3 as intracellular regulators of vascular remodeling

Wincewicz, Andrzej; Sulkowska, Mariola; Rutkowski, Ryszard; Sulkowski, Stanislaw; Musiatowicz, Boguslaw; Hirnle, Tomasz; Famulski, Waldemar; Koda, Mariusz; Sokol, Grzegorz; Szarejko, Przemyslaw

doi:10.1016/j.ejim.2006.12.007

« Previous Next »European Journal of Internal Medicine
Volume 18, Issue 4 , Pages 267-271, July 2007

STAT1 and STAT3 as intracellular regulators of vascular remodeling

Andrzej Wincewicz
- Department of Pathology, Waszyngtona St 13, 15-269 Białystok, Collegium Pathologicum, Medical University of Bialystok, Poland
- Corresponding author. Department of Pathology, Medical University of Bialystok, Waszyngtona St 13, 15-269 Bialystok, Poland. Tel.: +48 85 748 59 45; fax: +48 85 748 59 44.
Mariola Sulkowska
- Department of Pediatric Allergology, Waszyngtona St 17, 15-274 Bialystok, Dr Ludwik Zamenhof Memorial Children Clinic Hospital, Medical University of Bialystok, Poland
Ryszard Rutkowski
- Department of Pediatric Allergology, Waszyngtona St 17, 15-274 Bialystok, Dr Ludwik Zamenhof Memorial Children Clinic Hospital, Medical University of Bialystok, Poland
Stanislaw Sulkowski
- Department of Pathology, Waszyngtona St 13, 15-269 Białystok, Collegium Pathologicum, Medical University of Bialystok, Poland
Boguslaw Musiatowicz
- Department of Pathology, Waszyngtona St 13, 15-269 Białystok, Collegium Pathologicum, Medical University of Bialystok, Poland
Tomasz Hirnle
- Department of Cardiac Surgery, M. Skłodowskiej-Curie St 24A, 15-276 Public Clinic Hospital of Medical University in Bialystok, Poland
Waldemar Famulski
- Department of Pathology, Waszyngtona St 13, 15-269 Białystok, Collegium Pathologicum, Medical University of Bialystok, Poland
Mariusz Koda
- Department of Pathology, Waszyngtona St 13, 15-269 Białystok, Collegium Pathologicum, Medical University of Bialystok, Poland
Grzegorz Sokol
- Traumathology Unit Frederick Chopin Memorial Voivodeship Specialistic Hospital of Rzeszow, Poland
Przemyslaw Szarejko
- Department of Family Medicine and Community Nursing, Medical University of Bialystok, Mieszka I St 4B, 15-054 Bialystok, Poland

Received 12 August 2006; accepted 29 December 2006. published online 26 May 2007.

Abstract

The roles of signal transducers and activators of transcription (STAT) proteins are widely discussed in the pathogenesis of cardiovascular diseases. It is highly probable that STAT1 and STAT3 are activated during proliferation and inflammation inside atheromatous plaques. Luminal surfaces of endothelium become thrombogenic because of STAT1-dependent induction of MHC II and STAT3-regulated recruitment of phospholipase A2. As with STAT1, STAT3 seems to mediate stimulation of vascular wall cells by VEGF, HGF, and Ang II. STAT3 can contribute to counteracting apoptosis by eventual cooperation with c-fos and the bcl-xl gene. As pharmacological agents called statins are reported to regulate activities of STAT proteins, these signal messenger proteins could serve as targets for anti-atherogenic therapy. We attempted to review the role of STAT1 and STAT3 proteins in vascular remodeling.

Keywords: Signal transduction, Remodeling, Atherosclerosis, Statins, Apoptosis