European Journal of Internal Medicine
Volume 19, Issue 1 , Pages 1-7, January 2008

Causes and mechanisms of acid–base and electrolyte abnormalities in cancer patients

Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece

Received 9 August 2006; received in revised form 8 February 2007; accepted 20 April 2007. published online 28 July 2007.

Abstract 

Patients with cancer frequently exhibit acid–base and electrolyte disturbances that complicate their management and prolong their hospitalization. The mechanisms encountered for these abnormalities are multifactorial in origin. Both the underlying disease and the therapeutic interventions can contribute to the development of these disturbances. An understanding of the mechanisms involved in their pathogenesis is of paramount importance for their prevention and treatment in cancer patients. This article briefly reviews the causes and the pathophysiology of acid–base and electrolyte abnormalities observed in cancer patients.

Keywords: Cancer, Acid–base abnormalities, Electrolyte abnormalities, Chemotherapy

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PII: S0953-6205(07)00185-9

doi:10.1016/j.ejim.2007.04.016

European Journal of Internal Medicine
Volume 19, Issue 1 , Pages 1-7, January 2008

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