European Journal of Internal Medicine
Volume 19, Issue 1 , Pages 1-7 , January 2008

Causes and mechanisms of acid–base and electrolyte abnormalities in cancer patients

Received 9 August 2006 ,Revised 8 February 2007 ,Accepted 20 April 2007.

References 

  1. Flombaum CD. Metabolic emergencies in the cancer patient. Semin Oncol. 2000;27(3):322–334
  2. Harrigan MR. Cerebral salt wasting syndrome: a review. Neurosurgery. 1996;38(1):152–160
  3. Sorensen JB, Andersen MK, Hansen HH. Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) in malignant disease. J Intern Med. 1995;238(2):97–110
  4. Bode U, Seif SM, Levine AS. Studies on the antidiuretic effect of cyclophosphamide: vasopressin release and sodium excretion. Med Pediatr Oncol. 1980;8(3):295–303
  5. Hammond IW, Ferguson JA, Kwong K, Muniz E, Delisle F. Hyponatremia and syndrome of inappropriate anti-diuretic hormone reported with the use of Vincristine: an over-representation of Asians?. Pharmacoepidemiol Drug Saf. 2002;11(3):229–234
  6. Ritch PS. Cis-dichlorodiammineplatinum II-induced syndrome of inappropriate secretion of antidiuretic hormone. Cancer. 1988;61(3):448–450
  7. Danielides V, Millionis HJ, Karavasilis V, Briasoulis E, Elisaf M. Syndrome of inappropriate antidiuretic hormone secretion due to recurrent oral cancer. B-ENT. 2005;1(3):151–153
  8. Wall BM, Crofton JT, Share L, Cooke CR. Chronic hyponatremia due to resetting of the osmostat in a patient with gastric carcinoma. Am J Med. 1992;93(2):223–228
  9. Elisaf M, Konstantinides A, Siamopoulos KC. Chronic hyponatremia due to recent osmostat in a patient with colon cancer. Am J Nephrol. 1997;17(2):153–157
  10. Olivero JJ. Case in point. Pseudohyponatremia due to hyperproteinemia in multiple myeloma. Hosp Pract (Off Ed). 1994;29(8):61
  11. Klastersky J. Side effects of ifosfamide. Oncology. 2003;65(Suppl 2):7–10
  12. Goldman RD, Koren G. Amphotericin B nephrotoxicity in children. J Pediatr Hematol Oncol. 2004;26(7):421–426
  13. Adams PC, Woodhouse KW, Adela M, Parnham A. Exaggerated hypokalaemia in acute myeloid leukaemia. Br Med J (Clin Res Ed). 1981;282:1034–1035
  14. Taguchi T, Nazneen A, Abid MR, Razzaque MS. Cisplatin-associated nephrotoxicity and pathological events. Contrib Nephrol. 2005;148:107–121
  15. Filippatos TD, Milionis HJ, Elisaf MS. Alterations in electrolyte equilibrium in patients with acute leukemia. Eur J Haematol. 2005;75(6):449–460
  16. Milionis HJ, Bourantas CL, Siamopoulos KC, Elisaf MS. Acid–base and electrolyte abnormalities in patients with acute leukemia. Am J Hematol. 1999;62(4):201–207
  17. Bellevue R, Dosik H, Spergel G, Gussoff BD. Pseudohyperkalemia and extreme leukocytosis. J Lab Clin Med. 1975;85(4):660–664
  18. Lameire NH, Flombaum CD, Moreau D, Ronco C. Acute renal failure in cancer patients. Ann Med. 2005;37:13–25
  19. Goren MP. Cisplatin nephrotoxicity affects magnesium and calcium metabolism. Med Pediatr Oncol. 2003;41(3):186–189
  20. Lajer H, Kristensen M, Hansen HH, Nielsen S, Frokiaer J, Ostergaard LF, et al. Magnesium depletion enhances cisplatin-induced nephropathy. Cancer Chemother Pharmacol. 2005;56(5):535–542
  21. Davis BB, Preuss HG, Murdaugh HV. Hypomagnesemia following the diuresis of post-renal obstruction and renal transplant. Nephron. 1975;14(3–4):275–280
  22. Lacy MQ, Gertz MA. Acquired Fanconi's syndrome associated with monoclonal gammopathies. Hematol Oncol Clin North Am. 1999;13(6):1273–1280
  23. Dash T, Parker MG, Lafayette RA. Profound hypophosphatemia and isolated hyperphosphaturia in two cases of multiple myeloma. Am J Kidney Dis. 1997;29(3):445–448
  24. Rogowska E, Wozniak W. Nephrotoxicity of ifosfamide with special reference to Fanconi Syndrome. Med Wieku Rozwoj. 2004;8(2 Pt 1):289–295
  25. Carpenter TO. Oncogenic osteomalacia—a complex dance of factors. N Engl J Med. 2003;348(17):1705–1708
  26. Reese DM, Rosen PJ. Oncogenic osteomalakia associated with prostate cancer. J Urol. 1997;158:887
  27. Pelger R, Lycklama A, Nijeholt G, Papapoulos S, Hamdy N. Severe hypophosphatemic osteomalakia in hormone-refractory prostate cancer metastatic to the skeleton: natural history and pitfalls in management. Bone. 2005;36:1–5
  28. Yu X, White KE. FGF23 and disorders of phosphate homeostasis. Cytokine Growth Factor Rev. 2005;16(2):221–232
  29. Liamis G, Elisaf M. Hypokalemia, hypophosphatemia and hypouricemia due to proximal renal tubular dysfunction in acute myeloid leukemia. Eur J Haematol. 2000;64(4):277–278
  30. Salem RR, Tray K. Hepatic resection-related hypophosphatemia is of renal origin as manifested by isolated hyperphosphaturia. Ann Surg. 2005;241(2):343–348
  31. Tokmakjian S, Moses G, Haines M. Excessive sample blanking in two analyzers generate reports of apparent hypoglycemia and hypophosphatemia in patients with macroglobulinemia. Clin Chem. 1990;36:1261–1262
  32. Bushinsky DA, Monk RD. Electrolyte quintet: calcium. Lancet. 1998;352(9124):306–311
  33. Keller ET, Brown J. Prostate cancer bone metastases promote both osteolytic and osteoblastic activity. J Cell Biochem. 2004;91(4):718–729
  34. Mundy GR, Guise TA. Hypercalcemia of malignancy. Am J Med. 1997;103(2):134–145
  35. Steward AF. Hypercalcemia associated with cancer. N Engl J Med. 2005;352:373–379
  36. Guise TA, Yin JJ, Taylor SD, Kumagai Y, Dallas M, Boyce BF, et al. Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancer-mediated osteolysis. J Clin Invest. 1996;98(7):1544–1549
  37. Mundy GR, Bertolini DR. Bone destruction and hypercalcemia in plasma cell myeloma. Semin Oncol. 1986;13(3):291–299
  38. Seymour JF, Gagel RF. Calcitriol: the major humoral mediator of hypercalcemia in Hodgkin's disease and non-Hodgkin's lymphomas. Blood. 1993;82(5):1383–1394
  39. Locatelli F, Rossi F. Incidence and pathogenesis of tumor lysis syndrome. Contrib Nephrol. 2005;147:61–68
  40. Doolittle GC, Wurster MW, Rosenfeld CS, Bodensteiner DC. Malignancy-induced lactic acidosis. South Med J. 1988;81(4):533–536
  41. Sculier JP, Nicaise C, Klastersky J. Lactic acidosis: a metabolic complication of extensive metastatic cancer. Eur J Cancer Clin Oncol. 1983;19(5):597–601
  42. Hove H. Lactate and short chain fatty acid production in the human colon: implications for D-lactic acidosis, short-bowel syndrome, antibiotic-associated diarrhea, colonic cancer and inflammatory bowel disease. Dan Med Bull. 1998;45(1):15–33

PII: S0953-6205(07)00185-9

doi: 10.1016/j.ejim.2007.04.016

European Journal of Internal Medicine
Volume 19, Issue 1 , Pages 1-7 , January 2008