European Journal of Internal Medicine
Volume 19, Issue 2 , Pages 137-139 , March 2008

Limitations of the QuantiFERON®-TB Gold test in detecting Mycobacterium tuberculosis infection in immunocompromised patients

  • Mads Hornum

      Affiliations

    • Department of Nephrology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    • Corresponding Author InformationCorresponding author. Department of Nephrology 2131 Rigshospitalet Blegdamsvej 9 DK-2100 Copenhagen Denmark. Tel.: +45 3545 1762; fax: +45 3545 2607.
    • ,
  • Klaus Leth Mortensen

      Affiliations

    • Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    • ,
  • Anne-Lise Kamper

      Affiliations

    • Department of Nephrology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    • ,
  • Åse Bengård Andersen

      Affiliations

    • Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

Received 14 December 2006 ,Accepted 9 March 2007.

References 

  1. Andersen P, Munk ME, Pollock JM, Doherty TM. Specific immune-based diagnosis of tuberculosis. Lancet. 2000;356(9235):1099–1104
  2. Mazurek GH, Jereb J, Lobue P, Iademarco MF, Metchock B, Vernon A. Guidelines for using the QuantiFERON-TB Gold test for detecting Mycobacterium tuberculosis infection, United States. MMWR Recomm Rep. 2005;54(RR–15):49–55
  3. Mori T, Sakatani M, Yamagishi F, Takashima T, Kawabe Y, Nagao K, et al. Specific detection of tuberculosis infection: an interferon-gamma-based assay using new antigens. Am J Respir Crit Care Med. 2004;170(1):59–64
  4. Codeluppi M, Cocchi S, Guaraldi G, Di Benedetto F, De Ruvo N, Meacci M, et al. Posttransplant Mycobacterium tuberculosis disease following liver transplantation and the need for cautious evaluation of Quantiferon TB GOLD results in the transplant setting: a case report. Transplant Proc. 2006;38(4):1083–1085
  5. Ulrichs T, Munk ME, Mollenkopf H, Behr-Perst S, Colangeli R, Gennaro ML, et al. Differential T cell responses to Mycobacterium tuberculosis ESAT6 in tuberculosis patients and healthy donors. Eur J Immunol. 1998;28(12):3949–3958
  6. van Pinxteren LA, Ravn P, Agger EM, Pollock J, Andersen P. Diagnosis of tuberculosis based on the two specific antigens ESAT-6 and CFP10. Clin Diagn Lab Immunol. 2000;7(2):155–160

PII: S0953-6205(07)00237-3

doi: 10.1016/j.ejim.2007.03.020

European Journal of Internal Medicine
Volume 19, Issue 2 , Pages 137-139 , March 2008

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