European Journal of Internal Medicine
Volume 19, Issue 5 , Pages 319-324 , July 2008

Lymphangioleiomyomatosis: A review

  • Donald W. Hohman

      Affiliations

    • Department of Medical Education, Kern Medical Center, Bakersfield, Ca, United States
    • Corresponding Author InformationCorresponding author. Kern Medical Center, Department of Medical Education, 1830 Flower Street Bakersfield, Ca 93305, United States.
    • These authors have contributed equally to the production of this Review Article.
    • ,
  • Dena Noghrehkar

      Affiliations

    • Department of Medical Education, Kern Medical Center, Bakersfield, Ca, United States
    • These authors have contributed equally to the production of this Review Article.
    • ,
  • Saman Ratnayake

      Affiliations

    • Department of Medical Education, Kern Medical Center, Bakersfield, Ca, United States
    • Department of Internal Medicine, UCLA, United States

Received 11 May 2007 ,Revised 17 October 2007 ,Accepted 21 October 2007.

References 

  1. Taylor JR, Ryu J, Colby TV, Raffin TA. Lymphangioleiomyomatosis: clinical course in 32 patients. N Engl J Med. 1990;323:1254–1260
  2. Kitaichi M, Nishimura K, Itoh H, Izumi T. Pulmonary Lymphangioleiomyomatosis: a report of 46 patients including a clinicopathologic study of prognostic factors. Am J Respir Crit Care Med. 1995;151:527–533
  3. Corrin B, Liebow AA, Friedman PJ. Pulmonary lymphangioleiomyomatosis: a review. Am J Pathol. 1975;79:348–382
  4. Kalassian KG, Doyle R, Kao P, Ruoss S, Raffin TA. Lymphangioleiomyomatosis: new insights. Am J Respir Crit Care Med. 1997;155:1183–1186
  5. Costello LC, Hartman TE, Ryu JH. High frequency of pulmonary lymphangioleiomyomatosis in women with tuberous sclerosis complex. Mayo Clin Proc. 2000;75:591–594
  6. Franz DN, Brody A, Meyer C, Leonard J, Chuck G, Dabora S. Mutation and radiographic analysis of pulmonary disease consistent with lymphangioleiomyomatosis and micronodular pneumocyte hyperplasia in women with tuberous sclerosis. Am J Respir Crit Care Med. 2001;164:661–668
  7. Carrington CB, Cugell DW, Gaensler EA, Marks A, Redding RA, Schaaf JT. Lymphangioleiomyomatosis: physiologic-pathologic-radiologic correlations. Am Rev Respir Dis. 1977;116:977–995
  8. Hayashi T, Fleming MV, Stetler-Stevenson WG, Fishback N, Koss MN, Liotta LA. Immunohistochemical study of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in pulmonary Lymphangioleiomyomatosis (LAM). Hum Pathol. 1997;28:1071–1078
  9. Taviera-DaSilva A, Steagall W, Moss J. Lymphangioleiomyomatosis. Cancer Control. 2006;13(4):276–285
  10. Johnson S. Lymphangioleiomyomatosis: clinical features, management and basic mechanisms. Thorax. 1999;54:254–264
  11. Yamazaki A, Miyamoto H, Futagawa T, Oh W, Sonobe S, Takahashi N. An early case of pulmonary lymphangioleiomyomatosis diagnosed by video-assisted thoracoscopic surgery. Ann Thorac Cardiovasc Surg. 2005;11(6):405–408
  12. Bonetti F, Chiodera P, Pea M, Martignoni G, Bosi F, Zamboni G. Transbronchial biopsy in lymphangioleiomyomatosis of the lung: HMB 45 for diagnosis. Am J Surg Pathol. 1993;17:1092–1102
  13. Boehler A, Speich R, Russi EW, Weder W. Lung transplantation for lymphangioleiomyomatosis. N Engl J Med. 1996;335:1275–1280
  14. Finlay G. Am J Physiol Lung Cell Mol Physiol. 2004;286:690–693
  15. Dwyer JM, Hickie JB, Garvan J. Pulmonary tuberous sclerosis: report of three patients and review of the literature. Q J Med. 1971;40:115–125
  16. Castro M, Shepherd CW, Gomez MR, Lie JT, Ryu JH. Pulmonary tuberous sclerosis. Chest. 1995;107:189–195
  17. Capron F, Ameille J, Leclerc P, Mornet P, Barbagellata M, Reynes M. Pulmonary lymphangioleiomyomatosis and Bournevile's tuberous sclerosis with pulmonary involvement: the same disease?. Cancer. 1983;52:851–855
  18. Aberle DR, Hansell DM, Brown K, Tashkin DP. Lymphangioleiomyomatosis: CT, chest radiographic, and functional correlations. Radiology. 1990;176:381–387
  19. Chu S, Horiba K, Usuki J, Avila N, Chen C, Travis W, et al. Comprehensive evaluation of 35 patients with lymphangioleiomyomatosis. Chest. 1999;115:1041–1052
  20. Sullivan EJ. Lymphangioleiomyomatosis: a review. Chest. 1998;114:1689–1703
  21. Muller NL, Chiles C, Kullnig P. Pulmonary lymphangioleiomyomatosis: correlation of CT with radiographic and functional findings. Radiology. 1990;175:335–339
  22. Lenoir S, Grenier P, Brauner MW, Frija J, Remy-Jordin M. Pulmonary lymphangioleiomyomatosis and tuberous sclerosis: comparison of radiographic and thin-section CT findings. Radiology. 1990;175:329–334
  23. Green AJ, Smith M, Yates JR. Loss of heterozygosity on chromosome 16p13.3 in hamartomas from tuberous sclerosis patients. Nat Genet. 1994;6:193
  24. Shen A, Iseman MD, Waldron JA, King TE. Exacerbation of pulmonary lymphangioleiomyomatosis by exogenous estrogens. Chest. 1987;91:782–785
  25. Yano S. Exacerbation of pulmonary lymphangioleiomyomatosis by exogenous oestrogen used for infertility treatment. Thorax. 2002;57:1085–1086
  26. Warren SE, Lee D, Martin V, Messink W. Pulmonary lymphangiomyomatosis causing bilateral pneumothorax during pregnancy. Ann Thorac Surg. 1993;55:998–1000
  27. Brunelli A, Catalini G, Fianchini A. Pregnancy exacerbating unsuspected mediastinal lymphangioleiomyomatosis and chylothorax. Int J Gynecol Obstet. 1996;52:289–290
  28. Hughes E, Hodder RV. Pulmonary lymphangiomyomatosis complicating pregnancy. A case report. J Reprod Med. 1987;32:553–557
  29. Barberis M, Monti GP, Ziglio G, De Juli E, Veronese S, Harari S. Oestrogen and progesterone receptors, detection in pulmonary lymphangioleiomyomatosis. Am J Respir Crit Care Med. 1996;153:A272
  30. Taviera-DaSilva A, Stylianou M, Hedin C, Hathaway O, Moss J. Decline in lung function in patients with lymphangioleiomyomatosis treated with or without progesterone. Chest. 2004;126:1867–1874
  31. Banner AS, Carrington CB, Emory WB, Kittle F, Leonard G, Ringus J. Efficacy of oophorectomy in lymphangioleiomyomatosis and benign metastasizing leiomymoma. N Engl J Med. 1981;305:204–209
  32. Wahedna I, Cooper S, Williams J, Britton JR, Paterson IC, Tattersfield AE. Relation of pulmonary lymphangioleiomyomatosis to the use of the oral contraceptive pill and fertility in the UK: a national case control study. Thorax. 1994;49:910–914
  33. Rossi GA, Balbi B, Oddera S, Lantero S, Ravazzoni C. Response to treatment with an analog of the luteinizing-hormone- releasing hormone in a patient with pulmonary lymphangioleiomyomatosis. Am Rev Respir Dis. 1991;143:174
  34. Eliasson AH, Phillips YY, Tenholder MF. Treatment of lymphangioleiomyomatosis. A meta-analysis. Chest. 1989;96:1352
  35. Urban T, Kuttenn F, Gompel A, Marsac J, Lacronique J. Pulmonary lymphangiomyomatosis: follow-up and long-term outcome with antiestrogen therapy; a report of eight cases. Chest. 1992;102:472
  36. Urban T, Lazor R, Lacronique J, Murris M, Labrune S, Valeyre D. Pulmonary lymphangioleiomyomatosis. A study of 69 patients. Groupe d'Etudes et de Recherche sur les Maladies “Orphelines” Pulmonaires (GERM"O"P). Medicine (Baltimore). 1999;78:321
  37. Cohen M, BarZiv S, Johnson S. Emerging clinical picture of lymphangioleiomyomatosis. Thorax. 2005;60:875–879
  38. Smolarek TA, Wessner LL, McCormack FX. Evidence that lymphangiomyomatosis is caused by TSC2 mutations: chromosome 16p13 loss of heterozygosity in angiomyolipomas and lymph nodes from women with lymphangiomyomatosis. Am J Hum Genet. 1998;62:810
  39. Patton KT, Cheng L, Papavero V, Blum MG, Yeldandi AV, Adley BP, et al. Benign metastasizing leiomyoma: clonality, telomere length and clinicopathologic analysis. Mod Pathol. Jan 2006;19(1):130–140
  40. Ohori NP, Yousem SA, Sonmez-Alpan E, Colby TV. Estrogen and progesterone receptors in lymphangioleiomyomatosis, epithelioid hemangioendothelioma, and sclerosing hemangioma of the lung. Am J Clin Pathol. 1991;96:529
  41. Matsui K, Takeda K, Yu ZX, Valencia J, Travis WD, Moss J. Downregulation of estrogen and progesterone receptors in the abnormal smooth muscle cells in pulmonary lymphangioleiomyomatosis following therapy. An immunohistochemical study. Am J Respir Crit Care Med. 2000;161:1002
  42. Schiavina M, Di Scioscio V, Contini P, Cavazza A, Fabiani A, Barberis M, et al. Pulmonary lymphangioleiomyomatosis in a karyotypically normal man without tuberous sclerosis complex. Am J Respir Crit Care Med. Jul 1 2007;176(1):96–98
  43. Fiore MG, Sanguedolce F, Lolli I, Piscitelli D, Ricco R. Abdominal lymphangioleiomyomatosis in a man with Klinefelter syndrome: the first reported case. Ann Diagn Pathol. Apr 2005;9(2):96–100
  44. Ryu Jay H, Moss Joel, Beck Gerald J, Lee Jar-Chi, Brown Kevin K, Chapman Jeffrey T, et al. The NHLBI Lymphangioleiomyomatosis Registry. Characteristics of 230 patients at enrollment. Am J Respir Crit Care Med. 2006;173:105–111
  45. Steagall WK, Taveira-DaSilva AM, Moss J. Sarcoidosis Vasc Diffuse Lung Dis. Dec 2005;22(Suppl 1):S49–S66
  46. Johnson SR. Eur Respir J. May 2006;27(5):1056–1065
  47. Johnson SR, Tattersfield AE. Treatment and outcome of lymphangioleiomyomatosis in the UK. Am J Respir Crit Care Med. 1997;155:A327
  48. Reid LM. Reduction in bronchial subdivision in bronchiectasis. Thorax. Sep 1950;5(3):233–247
  49. McCormack F, Brody A, Meyer C, Leonard J, Chuck G, Dabora S, et al. Pulmonary cysts consistent with lymphangioleiomyomatosis are common in women with tuberous sclerosis. Chest. 2002;121:61S
  50. Carsillo T, Astrinidis A, Henske EP. Mutations in the tuberous sclerosis complex gene TSC2 are a cause of sporadic pulmonary lymphangioleiomyomatosis. Proc Natl Acad Sci U S A. 2000;97:6085–6090

PII: S0953-6205(07)00297-X

doi: 10.1016/j.ejim.2007.10.015

European Journal of Internal Medicine
Volume 19, Issue 5 , Pages 319-324 , July 2008

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