Serum C-reactive protein at admission predicts in-hospital mortality in medical patients

Abstract 

Background

Previous studies have examined the role of inflammatory markers in patients with coronary heart disease, stroke, chronic renal failure and other selected patient populations. The aim of this study was to assess the clinical utility of serum C-reactive protein (CRP) at admission in predicting outcome in hospitalized medical patients.

Methods

All patients admitted to our medical department were eligible to be included in the study. At the time of admission, demographic and clinical information was obtained. CPR was measured within 12 h of hospitalization. The results were analyzed using Cox proportional hazards multiple regression model.

Results

Three hundred eighty-two patients were included in the study (186 males and 196 females). Age (mean±standard deviation) was 70.8±15.7 years. Serum CRP [median (interquartile range) at admission was 29.7 mg/l (6.6–114.3). Serum CRP at admission was independently associated with in-hospital death. Levels above 120 mg/l increased the probability of fatal outcome three fold (hazard ratio=2.98, 95% confidence interval: 1.35–6.58). In patients older than 80 years, CRP at admission was a stronger predictor of in-hospital death (hazard ratio=5.41, 95% confidence interval: 1.38–21.26).

Conclusions

Serum CRP at admission is an independent predictor of mortality in hospitalized patients, particularly in the elderly. Admission CRP higher than 120 mg/l was associated with increased probability of in-hospital death (three fold in the overall population and five fold in the elderly subgroup) compared with lower levels.

Keywords: C-reactive protein, Mortality, Systemic inflammatory response syndrome, Elderly, Infection