European Journal of Internal Medicine
Volume 19, Issue 4 , Pages 261-265 , June 2008

Serum C-reactive protein at admission predicts in-hospital mortality in medical patients

  • M. Kompoti

      Affiliations

    • First Medical Department, Evangelismos Hospital, Athens, Greece
    • Corresponding Author InformationCorresponding author. Tel.: +30 210 93 18 700.
    • ,
  • S. Drimis

      Affiliations

    • Third Medical Department, Tzanion General Hospital, Pireus, Greece
    • ,
  • A. Papadaki

      Affiliations

    • Third Medical Department, Tzanion General Hospital, Pireus, Greece
    • ,
  • K. Kotsomytis

      Affiliations

    • Third Medical Department, Tzanion General Hospital, Pireus, Greece
    • ,
  • C. Poulopoulou

      Affiliations

    • Department of Biopathology, Tzanion General Hospital, Pireus, Greece
    • ,
  • D. Gianneli

      Affiliations

    • Department of Biopathology, Tzanion General Hospital, Pireus, Greece
    • ,
  • D. Voutsinas

      Affiliations

    • Third Medical Department, Tzanion General Hospital, Pireus, Greece

Received 8 October 2006 ,Revised 21 April 2007 ,Accepted 12 June 2007.

References 

  1. Epstein FH. Acute-phase proteins and other systemic responses to inflammation. N Engl J Med. 1999;340:448–454
  2. Visser M, Bouter LM, McQuillan GM, Wener MH, Harris TB. Elevated C-reactive protein levels in overweight and obese adults. JAMA. 1999;282:2131–2135
  3. Rallidis LS, Vikelis M, Panagiotakos DB, Rizos I, Zolindakis MG, Kaliva K, et al. Inflammatory markers and in-hospital mortality in acute ischaemic stroke. Atherosclerosis. 2006;189:193–197
  4. Montaner J, Fernandez-Cadenas I, Molina CA, Ribo M, Huertas R, Rosell A, et al. Poststroke C-reactive protein is a powerful prognostic tool among candidates for thrombolysis. Stroke. 2006;37:1205–1210
  5. Winbeck K, Poppert H, Etgen T, Conrad B, Sander D. Prognostic relevance of early serial C-reactive protein measurements after first ischemic stroke. Stroke. 2002;33:2459–2464
  6. Avram MM, Fein PA, Paluch MM, Schloth T, Chattopadhyay J. Association between C-reactive protein and clinical outcomes in peritoneal dialysis patients. Adv Perit Dial. 2005;21:154–158
  7. Wang AY, Woo J, Lam CW, Wang M, Sea MM, Lui S-F, et al. Is a single time point C-reactive protein predictive of outcome in peritoneal dialysis patients?. J Am Soc Nephrol. 2003;14:1871–1879
  8. Yeun JY, Levine RA, Mantadilok V, Kaysen GA. C-reactive protein predicts all-cause and cardiovascular mortality in hemodialysis patients. Am J Kidney Dis. 2000;35:469–476
  9. Liuzzo G, Biasucci LM, Gallimore JR, Grillo RL, Rebuzzi AG, Pepys MB, et al. The prognostic value of C-reactive protein and serum amyloid A protein in severe unstable angina. N Engl J Med. 1994;331:417–424
  10. Haverkate F, Thompson SG, Pyke SDM, Gallimore JR Pepys MB for the European Concerted Action on Thrombosis and Disabilities Angina Pectoris Study Group. Production of C-reactive protein and risk of coronary events in stable and unstable angina. Lancet. 1997;349:462–466
  11. Presterl E, Standinger T, Pettermann M, Lassnigg A, Burgmann H, Winkler S, et al. Cytokine profile and correlation to the APACHE III and MPMII scores in patients with sepsis. Am J Respir Crit Care. 1997;156:825–832
  12. Wilson C, Heads A, Shenkin A, Imrie CW. C-reactive protein, antiproteases and complement factors as objective markers of severity in acute pancreatitis. Br J Surg. 1989;76:177–181
  13. Neoptolemos JP, Kemppainen EA, Mayer JM, Fitzpatrick JM, Raraty MG, Slavin J, et al. Early prediction of severity in acute pancreatitis by urinary trypsinogen activation peptide: a multicentre study. Lancet. 2000;355:1955–1960
  14. Ridker PM, Cushman M, Stampfer MJ, Tracy RP, Hennekens CH. Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. N Engl J Med. 1997;336:973–979
  15. Rangel-Frausto MS, Pittet D, Costigan M, Hwang T, Davis CS, Wenzel RP. The natural history of the systemic inflammatory response syndrome (SIRS). A prospective study. JAMA. 1995;273:117–123
  16. Garner JS, Jarvis WR, Emon TC, Hughes JM. CDC definitions for nosocomial infections. In:  Olmsted RN editors. APIC Infection Control and Applied Epidemiology: Principles and Practice. St. Louis: Mosby; 1996;p. A1–A20
  17. In:  Haeckel R,  Buschm EW,  Jenningsm RD,  Trucheaudm A editor. Guidelines for the evaluation of an analysis in clinical chemistry: ECCLs Document 3. Berlin, Germany: Beuth Verlag; 1986;
  18. Sandberg AA, Borgström A. Early prediction of severity in acute pancreatitis. Is this possible?. J Pancreas. 2002;3:116–125
  19. Vanderschueren S, Deeren D, Knockaert DC, Bobbaers H, Bossuyt X, Peetermans W. Extremely elevated C-reactive protein. Eur J Intern Med. 2006;17:430–433
  20. Wei J, Xu H, Davies JL, Hemming GP. Increase of plasma IL-6 concentration with age in healthy subjects. Life Sci. 1992;51:1953–1956
  21. Daynes RA, Araneo BA, Ershler WB, Maloney C, Li G-Z, Ryu S-Y. Altered regulation of IL-6 production with normal aging. J Immunol. 1993;150:5219–5230
  22. Post DJ, Corter KC, Papaconstantinou J. The effect of aging on constitutive mRNA levels and lipopolysaccharide inducibility of acute phase genes. Ann NY Acad Sci. 1991;621:66–77
  23. Ross RD, Frengley JD. Elevated C-reactive protein in older people. J Am Geriat Soc. 1992;40:104–105
  24. Subbe CP, Kruger M, Rutherford P, Gemmel L. Validation of a modified Early Warning Score in medical admissions. QJM. 2001;94:521–526

PII: S0953-6205(07)00347-0

doi: 10.1016/j.ejim.2007.06.016

European Journal of Internal Medicine
Volume 19, Issue 4 , Pages 261-265 , June 2008

Article Tools

* Image Usage & Resolution