European Journal of Internal Medicine
Volume 19, Issue 7 , Pages 488-493 , November 2008

Update of nutrient-deficiency anemia in elderly patients

  • Emmanuel Andrès

      Affiliations

    • Departments of Internal Medicine, Diabetes and Metabolic Disorders, University Hospital of Strasbourg, Strasbourg, France
    • Corresponding Author InformationCorresponding author. Service de Médecine Interne, Diabète et Maladies Métaboliques, Clinique Médicale B, Hôpital Civil, Hôpitaux Universitaires de Strasbourg, 1 porte de l'Hôpital, 67091 Strasbourg Cedex, France. Tel.: +33 3 33 88 11 50 66; fax: +33 3 33 88 11 62 62.
  • ,
  • Laure Federici

      Affiliations

    • Departments of Internal Medicine, Diabetes and Metabolic Disorders, University Hospital of Strasbourg, Strasbourg, France
  • ,
  • Khalid Serraj

      Affiliations

    • Departments of Internal Medicine, Diabetes and Metabolic Disorders, University Hospital of Strasbourg, Strasbourg, France
  • ,
  • Georges Kaltenbach

      Affiliations

    • Internal Medicine and Geriatrics, University Hospital of Strasbourg, Strasbourg, France

Received 25 May 2007 ,Revised 27 December 2007 ,Accepted 20 January 2008.

References 

  1. Eisenstaedt R, Penninx BW, Woodman RC. Anemia in the elderly: current understanding and emerging concepts. Blood Rev. 2006;20:213–226
  2. Carmel R. Anemia and aging: an overview of clinical, diagnostic and biological issues. Blood Rev. 2001;15:9–18
  3. Izaks GJ, Westendorp RG, Knook DL. The definition of anemia in older persons. JAMA. 1999;281:1714–1717
  4. Smith DL. Anemia in the elderly. Am Fam Phys. 2000;62:1565–1572
  5. Balducci L, Ershler WB, Krantz S. Anemia in the elderly. Clinical findings and impact on health. Crit Rev Oncol Hematol. 2006;58:156–165
  6. Andrès E, Perrin AE, Kraemer JP, Goichot B, Demangeat C, Ruellan A, et al. Anémies par carence en vitamine B12 chez le sujet âgé de plus de 75 ans: nouveaux concepts. A propos de 20 observations. Rev Med Interne. 2000;21:946–955
  7. National Health and Nutrition Examination Survey. Anthropometric Reference Data, United States. 1988–1994. http://www.cdc.gov/nchs/about/major/nhanes/Anthropometric%20Measures. March 7, 2007.
  8. Guralnik JM, Eisenstaedt RS, Ferrucci L, Klein HG, Woodman RC. Prevalence of anemia in persons 65 years and older in the United States: evidence for a high rate of unexplained anemia. Blood. 2004;104:2263–2268
  9. Fleming DJ, Jacques PF, Tucker KL, Massaro JM, D'Agostino RB, Wilson PW, et al. Iron status of the free-living, elderly Framingham Heart Study cohort: an iron-replete population with a high prevalence of elevated iron stores. Am J Clin Nutr. 2001;73:638–646
  10. Woodman R, Ferrucci L, Guralnik J. Anemia in older adults. Curr Opin Hematol. 2005;12:123–128
  11. Joosten E, Pelemans W, Hiele M, Noyen J, Verhaeghe R, Boogaerts MA. Prevalence and causes of anaemia in a geriatric hospitalization population. Gerontology. 1992;38:111–117
  12. Suzuki H, Marshall BJ, Hibi T. Overview: Helicobacter pylori and extragastric disease. Int J Hematol. 2006;84:291–300
  13. Rimon E, Levy S, Sapir A, Gelzer G, Peled R, Ergas D, et al. Diagnosis of iron deficiency anemia in the elderly by transferrin receptor-ferritin index. Arch Intern Med. 2002;162:445–449
  14. Rockey DC, Cello JP. Evaluation of the gastrointestinal tract in patients with iron-deficiency anemia. N Engl J Med. 1993;329:1691–1695
  15. Gordon S, Bensen S, Smith R. Long-term follow-up of older patients with iron deficiency anemia after a negative GI evaluation. Am J Gastroenterol. 1996;91:885–889
  16. Nahon S, Lahmek P, Massard J, Lesgourgues B, Mariaud de Serre N, Traissac L, et al. Helicobacter pylori-associated chronic gastritis and unexplained iron deficiency anemia: a reliable association?. Helicobacter. 2003;8:573–577
  17. Milman N, Pedersen AN, Ovesen L, Schroll M. Iron status in 358 apparently healthy 80-year-old Danish men and women: relation to food composition and dietary and supplemental iron intake. Ann Hematol. 2004;83:423–429
  18. Lindenbaum J, Rosenberg IH, Wilson PW, Stabler SP, Allen RH. Prevalence of cobalamin deficiency in the Framingham elderly population. Am J Clin Nutr. 1994;60:2–11
  19. Andrès E, Loukili NH, Noel E, Kaltenbach G, Ben Abdelgheni M, Perrin AE, et al. Vitamin B12 (cobalamin) deficiency in elderly patients. CAMJ. 2004;171:251–260
  20. Andrès E, Affenberger S, Vinzio S, Kurtz JE, Noel E, Kaltenbach G, et al. Food-cobalamin malabsorption in elderly patients: clinical manifestations and treatment. Am J Med. 2005;118:1154–1159
  21. Carmel R. Malabsorption of food-cobalamin. Bailliere's Clin Haematol. 1995;8:639–655
  22. Sato S. Iron deficiency: structural and microchemical changes in hair, nails, and skin. Semin Dermatol. 1991;10:313–319
  23. Federici L, Loukili NH, Zimmer J, Affenberger S, Maloisel F, Andrès E. Manifestations hématologiques de la carence en vitamine B12: données personnelles et revue de la littérature. Rev Med Interne. 2007;28:225–231
  24. Gabrilove J. Anemia and the elderly: clinical considerations. Best Prac Res Clin Haematol. 2005;18:417–422
  25. Yen PK. Nutritional anemia. Geriatric Nursing. 2000;21:111–112
  26. Umbreit J. Iron deficiency: a concise review. Am J Hematol. 2005;78:225–231
  27. Andrès E, Vidal-Alaball J, Federici L, Loukili NH, Zimmer J, Kaltenbach G. Clinical aspects of cobalamin deficiency in elderly patients. Epidemiology, causes, clinical manifestations, treatment with special focus on oral cobalamin therapy. Eur J Intern Med 2007 : in press.
  28. Vidal-Alaball J, Butler CC, Cannings-John R, Goringe A, Hood K, McCaddon A, et al. Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency. Cochrane Database Syst Rev. 2005;20:CD004655
  29. Wickramasinghe SN. Diagnosis of megaloblastic anaemias. Blood Rev. 2006;20:299–318

 Supported by a grant from the Fondation de France: Prix Robert et Jacqueline Zittoun, 2004.

PII: S0953-6205(08)00057-5

doi: 10.1016/j.ejim.2008.01.016

European Journal of Internal Medicine
Volume 19, Issue 7 , Pages 488-493 , November 2008