European Journal of Internal Medicine
Volume 20, Issue 1 , Pages 70-73 , January 2009

Intravenous immunoglobulins-induced eczematous eruption: A long-term follow-up study

  • F. Cohen Aubart

      Affiliations

    • Service de Pharmacologie et Centre Régional de Pharmacovigilance, AP-HP, Hôpital Pitié-Salpétrière, Paris, France
    • Corresponding Author InformationCorresponding author. Service de Pharmacologie, Hôpital Pitié-Salpétrière 83 boulevard de l'hôpital, 75013 Paris, France. Tel.: +33 1 42 16 16 70; fax: +33 1 42 16 16 81.
    • ,
  • S. Barete

      Affiliations

    • Département de dermatologie, AP-HP, Hôpital Tenon, Paris, France
    • ,
  • Z. Amoura

      Affiliations

    • Service de Médecine Interne, AP-HP, Hôpital Pitié-Salpétrière, Paris, France
    • ,
  • C. Francès

      Affiliations

    • Département de dermatologie, AP-HP, Hôpital Tenon, Paris, France
    • ,
  • Olivier Lyon-Caen

      Affiliations

    • Fédération des Maladies du Système Nerveux, AP-HP, Hôpital Pitié-Salpétrière, Paris, France
    • ,
  • B. Lebrun-Vignes

      Affiliations

    • Service de Pharmacologie et Centre Régional de Pharmacovigilance, AP-HP, Hôpital Pitié-Salpétrière, Paris, France

Received 6 September 2007 ,Revised 26 March 2008 ,Accepted 27 April 2008.

References 

  1. Nydegger UE, Sturzenegger M. Adverse effects of intravenous immunoglobulin therapy. Drug Safety. 1999;21:171–185
  2. Dalakas MC. Intravenous immune globulin therapy for neurologic diseases. Ann Intern Med. 1997;126:721–730
  3. Sorensen PS, Wanscher B, Jensen CV, Schreiber K, Blinkenberg M, Ravnborg M, et al. Intravenous immunoglobulin G reduces MRI activity in relapsing multiple sclerosis. Neurology. 1998;50:1273–1281
  4. Chan-Lam D, Fitzsimons EJ, Douglas WS. Alopecia after immunoglobulin infusion. Lancet. 1987;1:1436
  5. Howse M, Bindoff L, Carmichael A. Facial vasculitic rash associated with intravenous immunoglobulin. BMJ. 1998;317:1291
  6. Yockey SM, Ahmed I. Intravenous immunoglobulin-induced lichenoid dermatitis: a unique adverse reaction. Mayo Clin Proc. 1997;72:1151–1152
  7. Iannaccone S, Sferrazza B, Quattrini A, Smirne S, Ferini-Strambi L. Pompholyx (vesicular eczema) after i.v. immunoglobulin therapy for neurologic disease. Neurology. 1999;53:1154–1155
  8. Leclech C, Maillard H, Penisson-Besnier I, Laine-Cessac P, Verret JL. [Unusual skin reaction after intravenous infusion of polyvalent immunoglobulins: 3 case reports]. Presse Med. 1999;28:531
  9. Sarmiento E, Micheloud D, Carbone J. Complement consumption associated with eczematous cutaneous reaction during infusions of high doses of intravenous immunoglobulin. Br J Dermatol. 2004;151:721
  10. Barucha C, McMillan JC. Eczema after intravenous infusion of immunoglobulin. Br Med J (Clin Res Ed). 1987;295:1141
  11. Uyttendaele H, Obadiah J, Grossman M. Dyshidrotic-like spongiotic dermatitis after intravenous immunoglobulin therapy. J Drugs Dermatol. 2003;2:337–341
  12. Young PK, Ruggeri SY, Galbraith S, Drolet BA. Vesicular eczema after intravenous immunoglobulin therapy for treatment of Stevens–Johnson syndrome. Arch Dermatol. 2006;142:247–248
  13. Lonchamp P, Faure G, Schmutz JL, et al. A baboon syndrome induced by intravenous human immunoglobulins: report of a case and immunological analysis. Dermatology. 1999;199:258–260
  14. Vecchietti G, Kerl K, Prins C, Kaya G, Saurat JH, French LE. Severe eczematous skin reaction after high-dose intravenous immunoglobulin infusion: report of 4 cases and review of the literature. Arch Dermatol. 2006;142:213–217
  15. Hamdalla HH, Hawkes CH, Spokes EG, Bamford JM, Goulding PJ. Intravenous immunoglobulin in the Guillain–Barre syndrome. May cause severe adverse skin reactions. BMJ. 1996;313:1399–1400
  16. Whittam LR, Hay RJ, Hughes RA. Eczematous reactions to human immune globulin. Br J Dermatol. 1997;137:481–482
  17. Maetzke J, Sperfeld AD, Scharffetter-Kochanek K, Sunderkotter C. Vesicular and bullous eczema in response to intravenous immunoglobulins (IVIG). Allergy. 2006;61:145–146
  18. Catteau B, Delaporte E, Piette F. Meningitis and skin reaction after intravenous immune globulin therapy. Ann Intern Med. 1997;127:1130
  19. Ikeda K, Iwasaki Y, Ichikawa Y, Kinoshita M. Pompholyx after IV immunoglobulin therapy for neurologic disease. Neurology. 2000;54:1879

☆ The authors state that they did not receive any grant support and that there is no conflict of interest.

PII: S0953-6205(08)00137-4

doi: 10.1016/j.ejim.2008.04.022

European Journal of Internal Medicine
Volume 20, Issue 1 , Pages 70-73 , January 2009

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