European Journal of Internal Medicine
Volume 20, Issue 3 , Pages 289-295 , May 2009

Not all obese subjects of multiethnic origin are at similar risk for developing hypertension and type 2 diabetes

  • Virginia A. Genelhu

      Affiliations

    • Hypertension Clinic, Laboratory of Clinical and Experimental Pathophysiology, (CLINEX), School of Medicine, Rio de Janeiro State University, Brazil
    • ,
  • Bruno M.J. Celoria

      Affiliations

    • Hypertension Clinic, Laboratory of Clinical and Experimental Pathophysiology, (CLINEX), School of Medicine, Rio de Janeiro State University, Brazil
    • ,
  • Stenio Fernando Pimentel Duarte

      Affiliations

    • Hypertension Clinic, Laboratory of Clinical and Experimental Pathophysiology, (CLINEX), School of Medicine, Rio de Janeiro State University, Brazil
    • ,
  • Pedro H. Cabello

      Affiliations

    • Human Genetics Laboratory, Oswaldo Cruz Institute, Ministry of Health, Brazil
    • ,
  • Emilio A. Francischetti

      Affiliations

    • Hypertension Clinic, Laboratory of Clinical and Experimental Pathophysiology, (CLINEX), School of Medicine, Rio de Janeiro State University, Brazil
    • Corresponding Author InformationCorresponding author. Laboratory of Clinical and Experimental Pathophysiology — CLINEX, Rua Paulo Cesar de Andrade 106 ap. 602 — Laranjeiras, Rio de Janeiro — CEP 22221-090, Brazil. Tel.: +55 21 2587 6836; fax: +55 21 2587 6836.

Received 26 April 2008 ,Revised 26 August 2008 ,Accepted 22 September 2008.

References 

  1. Kearney PM, Whelton M, Reynolds K, Muntner P, Whelton PK, He J. Global burden of hypertension: analysis of worldwide data. Lancet. 2005;365:217–223
  2. Klein S, Burke LE, Bray GA, et al. Clinical implications of obesity with specific forms on cardiovascular disease: a statement for professionals from the American Heart Association Council on Nutrition, Physical Activity, and Metabolism. Circulation. 2004;110:2952–2967
  3. Felber JP, Golay A. Pathway from obesity to diabetes. Int J Obes. 2002;26(suppl 2):s39–s45
  4. Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care. 2004;27:1047–1053
  5. Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complication, part 1: diagnosis and classification of diabetes mellitus, provisional report of a WHO consultation. Diabet Med. 1998;15:539–553
  6. Executive Summary of the Third Report of The National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III). JAMA. 2001;285:2486–2497
  7. International Diabetes Federation. A new worldwide definition of the metabolic syndrome. Available from: www.idf.org (accessed April 02,2008).
  8. Lindsay RS, Howard BV. Cardiovascular risk associated with the metabolic syndrome. Curr Diab Rep. Feb 2004;4(1):63–68
  9. Ferrannini E, Natali A, Capaldo B, Lehtovirta M, Jacob S, Yhi-Järvinen H for the European Group for the Study of Insulin Resistance (EGIR). Insulin resistance, hyperinsulinemia, and blood pressure. Role of age and obesity. Hypertension. 1992;30:1144–1149
  10. Romero-Corral A, Montori VM, Somers VK, et al. Association of bodyweight with total mortality and with cardiovascular events in coronary artery disease: a systematic review of cohort studies. Lancet. 2006;368:666–678
  11. Flegal KM, Graubard BI, Williamson DF, Gail MH. Excess deaths associated with underweight, overweight, and obesity. JAMA. 2005;293:1861–1867
  12. McLaughlin T, Abbasi F, Lamendola C, Reaven G. Heterogeneity in the prevalence of risk factors for cardiovascular disease and type 2 diabetes mellitus in obese individuals. Arch Intern Med. 2007;167:642–648
  13. Duarte SF, Francischetti EA, Genelhu-Abreu V, et al. p.Q223R leptin receptor polymorphism associated with obesity in Brazilian multiethnic subjects. Am J Hum Biol. 2006;18:448–453
  14. Duarte SF, Francischetti EA, Genelhu VA, Cabello PH, Pimentel MM. LEPR p.Q223R, beta3-AR p.W64R and LEP c.-2548G>A gene variants in obese Brazilian subjects. Genet Mol Res. 2007;6:1035–1043
  15. Callegari-Jacques SM, Grattapaglia D, Salzano FM, et al. Historical genetics: spatiotemporal analysis of the formation of the Brazilian population. Am J Hum Biol. 2003;15:824–834
  16. The National High Blood Pressure Education Program Coordinating CommitteeChobanian AV, Bakris GL, Black HR, et al. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. JAMA. 2003;289:2560–2572
  17. World Health Organization . Obesity: preventing and managing the global epidemic. Geneva: World Health Organization; 1998;
  18. American Diabetes Association . Standards of medical care in diabetes—2007. Diabetes Care. 2007;30(Suppl 1):S4
  19. Nathan DM, Davidson MB, DeFronzo RA, et al. Impaired fasting glucose and impaired glucose tolerance: implications for care. Diabetes Care. 2007;30:753–759
  20. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412–419
  21. Patel DA, Srinivasan SR, Xu JH, Chen W, Berenson GS. Adiponectin and its correlates of cardiovascular risk in young adults: the Bogalusa Heart Study. Metabolism. 2006;55:1551–1557
  22. Iwashima Y, Katsuya T, Ishikawa K, et al. Hypoadiponectinemia is an independent risk factor for hypertension. Hypertension. 2004;43:1318–1323
  23. Eikelis N, Schlaich M, Aggarwel A, Kaye D, Esler M. Interaction between leptin and the human sympathetic nervous system. Hypertension. 2003;41:1072–1079
  24. da Silva AA, Kuo JJ, Hall JE. Role of hypothalamic melanocortin 3/4 receptors in mediatory chronic cardiovascular, renal and metabolic action of leptin. Hypertension. 2004;43:1312–1317
  25. Pollare T, Lithell H, Berne C. Insulin resistance is a characteristic feature of primary hypertension independent of obesity. Metabolism. 1990;39:167–174
  26. Manicardi V, Camellini L, Bellodi G, Caselii C, Ferrannini E. Evidence for an association of high blood pressure and hyperinsulinemia in obese man. J Clin Endocrinol Metab. 1986;62:1302–1304
  27. Landsberg L. Diet, obesity and hypertension: an hypothesis involving insulin, the sympathetic nervous system, and adaptive thermogenesis. Q J Med. 1986;61:1081–1090
  28. Francischetti EA, Genelhu VA. Obesity–hypertension: an ongoing pandemic. Int J Clin Pract. 2007;61:269–280
  29. Rumantir MS, Vaz M, Jennings GL, et al. Neural mechanisms in human obesity-related hypertension. J Hypertens. 1999;17:1125–1133
  30. Lambert E, Straznicky N, Schlaich M, et al. Differing pattern of sympathoexcitation in normal-weight and obesity-related hypertension. Hypertension. 2007;50:862–868
  31. Hall JE. The kidney, hypertension and obesity. Hypertension. 2003;41:625–633
  32. Hall JE. Pathophysiology of obesity hypertension. Curr Hypertens Rep. 2000;2:139–147
  33. Alvarez GE, Beske SD, Ballard TP, Davy KP. Sympathetic neural activation in visceral obesity. Circulation. 2002;106:2533–2536
  34. de Vriese AS, Verbeuren TJ, Van de Voorde J, Lameire NH, Vanhoutte PM. Endothelial dysfunction in diabetes. Br J Pharmacol. 2000;130:963–974
  35. Jeppesen J, Hansen TW, Rasmussen S, Ibsen H, Torp-Pedersen C, Madsbad S. Insulin resistance, the metabolic syndrome, and risk of incident cardiovascular disease. J Am Coll Cardiol. 2007;49:2112–2119
  36. Wilson PW, D'Augustino RB, Levy D, Belanger AM, Silbershatz H, Kannel WB. Prediction of coronary heart disease using risk factor categories. Circulation. 1998;97:1837–1847
  37. Bonora E, Targher G, Alberiche M, et al. Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity. Diabetes Care. 2000;23:57–63
  38. Bonora E, Willeit K, Oberhollenzer F, Meigs GEB, Bonadonna RC, Muggeo M. Insulin resistance as estimated by homeostasis model assessment predicts incident symptomatic cardiovascular disease in Caucasian subjects from the general population. Diabetes Care. 2007;30:318–324
  39. Jardim PCBV, Gondim MRP, Monego ET, et al. High blood pressure and some risk factors in a Brazilian capital. Arq Bras Cardiol. 2007;88:398–403

PII: S0953-6205(08)00274-4

doi: 10.1016/j.ejim.2008.09.009

European Journal of Internal Medicine
Volume 20, Issue 3 , Pages 289-295 , May 2009

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