European Journal of Internal Medicine
Volume 20, Issue 4 , Pages 398-402 , July 2009

Transitions between variant forms of primary biliary cirrhosis during long-term follow-up

  • Stefan Lindgren

      Affiliations

    • Department of Medicine, University Hospital MAS, Malmö, Sweden
    • Corresponding Author InformationCorresponding author. Department of Medicine, Gastroenterology and Hepatology Division, University Hospital MAS, S-20502 Malmö, Sweden. Tel.: +46 40 33 23 06; fax: +46 40 92 32 72.
  • ,
  • Hans Glaumann

      Affiliations

    • Department of Infectious Diseases and Pathology, Karolinska University Hospital at Huddinge, Stockholm, Sweden
  • ,
  • Sven Almer

      Affiliations

    • Division of Gastroenterology and Hepatology/IMK, University Hospital, Linköping, Sweden
  • ,
  • Annika Bergquist

      Affiliations

    • Department of Gastroenterology and Hepatology, Karolinska University Hospital at Huddinge, Stockholm, Sweden
  • ,
  • Einar Björnsson

      Affiliations

    • Department of Medicine, Sahlgrenska University Hospital/Sahlgrenska, Gothenburg, Sweden
  • ,
  • Ulrika Broomé

      Affiliations

    • Department of Gastroenterology and Hepatology, Karolinska University Hospital at Huddinge, Stockholm, Sweden
    • Deceased.
  • ,
  • Åke Danielsson

      Affiliations

    • Department of Medicine, Umeå University Hospital, Sweden
  • ,
  • Barbro Lebrun

      Affiliations

    • Department of Gastroenterology and Hepatology, Karolinska University Hospital at Huddinge, Stockholm, Sweden
    • Department of Medicine, Danderyds Hospital, Sweden
  • ,
  • Hanne Prytz

      Affiliations

    • Department of Medicine, Lund University Hospital, Sweden
  • ,
  • Rolf Olsson

      Affiliations

    • Department of Medicine, Sahlgrenska University Hospital/Sahlgrenska, Gothenburg, Sweden
    • Deceased.

Received 15 September 2008 ,Revised 14 November 2008 ,Accepted 18 December 2008.

References 

  1. Metcalf JV, Mitchison HC, Palmer JM, Jones DE, Bassendine MF, James OF. Natural history of early primary biliary cirrhosis. Lancet. 1996;348:1399–1402
  2. Oertelt S, Rieger R, Selmi C, Invernizzi P, Ansari AA, Coppel RL, et al. A sensitive bead assay for antimitochondrial antibodies: chipping away at AMA-negative primary biliary cirrhosis. Hepatology. 2007;45:659–665
  3. Invernizzi P, Crosignani A, Battezzati PM, Covini G, De Valle G, Larghi A, et al. Comparison of the clinical features and clinical course of antimitochondrial antibody-positive and -negative primary biliary cirrhosis. Hepatology. 1997;25:1090–1095
  4. Kim WR, Poterucha JJ, Jorgensen RA, Batts KP, Homburger HA, Dickson ER, et al. Does antimitochondrial antibody status affect response to treatment in patients with primary biliary cirrhosis? Outcomes of ursodeoxycholic acid therapy and liver transplantation. Hepatology. 1997;26:22–26
  5. Michieletti P, Wanless IR, Katz A, Scheuer PJ, Yeaman SJ, Bassendine MF, et al. Antimitochondrial antibody negative primary biliary cirrhosis: a distinct syndrome of autoimmune cholangitis. Gut. 1994;35:260–265
  6. Lacerda MA, Ludwig J, Dickson ER, Jorgensen RA, Lindor KD. Antimitochondrial antibody-negative primary biliary cirrhosis. Am J Gastroenterol. 1995;90:247–249
  7. Goodman ZD, McNally PR, Davis DR, Ishak KG. Autoimmune cholangitis: a variant of primary biliary cirrhosis. Clinicopathologic and serologic correlations in 200 cases. Dig Dis Sci. 1995;40:1232–1242
  8. Ben-Ari Z, Dhillon AP, Sherlock S. Autoimmune cholangiopathy: part of the spectrum of autoimmune chronic active hepatitis. Hepatology. 1993;18:10–15
  9. Chou MJ, Lee SL, Chen TY, Tsay GJ. Specificity of antinuclear antibodies in primary biliary cirrhosis. Ann Rheum Dis. 1995;54:148–151
  10. Gordon SC, Quattrociocchi-Longe TM, Khan BA, Kodali VP, Chen J, Silverman AL, et al. Antibodies to carbonic anhydrase in patients with immune cholangiopathies. Gastroenterology. 1995;108:1802–1809
  11. Gossard AA, Lindor KD. Development of autoimmune hepatitis in primary biliary cirrhosis. Liver Int. 2007;27:1086–1090
  12. Chazouillères O, Wendum D, Serfaty L, Montembault S, Rosmorduc O, Poupon R. Primary biliary cirrhosis-autoimmune hepatitis overlap syndrome: clinical features and response to therapy. Hepatology. 1998;28:296–301
  13. Horsmans Y, Piret A, Brenard R, Rahier J, Geubel AP. Autoimmune chronic active hepatitis responsive to immunosuppressive therapy evolving into a typical primary biliary cirrhosis syndrome: a case report. J Hepatol. 1994;21:194–198
  14. Alvarez F, Berg PA, Bianchi FB, Bianchi L, Burroughs AK, Cancado EL, et al. International Autoimmune Hepatitis Group Report: review of criteria for diagnosis of autoimmune hepatitis. J Hepatol. 1999;31:929–938
  15. Batts KP, Ludwig J. Chronic hepatitis. An update on terminology and reporting. Am J Surg Pathol. 1995;19:1409–1417
  16. Poupon R. Autoimmune overlapping syndromes. Clin Liver Dis. 2003;7:865–878
  17. Olsson R, Lindgren S, Glaumann H, Almer S, Broomé U, Lebrun B, et al. High prevalence of small duct primary sclerosing cholangitis among patients with overlapping autoimmune hepatitis and primary sclerosing cholangitis. Eur J Int Med 2009, in press.
  18. Woodward J, Neuberger J. Autoimmune overlap syndromes. Hepatology. 2001;33:994–1002
  19. Czaja AJ, Muratori P, Muratori L, Carpenter HA, Bianchi FB. Diagnostic and therapeutic implications of bile duct injury in autoimmune hepatitis. Liver Int. 2004;24:322–329
  20. Papamichalis PA, Zachou K, Koukoulis GK, Veloni A, Karacosta EG, Kypri L, et al. The revised international autoimmune hepatitis score in chronic liver diseases including autoimmune hepatitis/overlap syndromes and autoimmune hepatitis with concurrent other liver disorders. J Autoimmune Dis. 2007;4:3
  21. Chazouillères O, Wendum D, Serfaty L, Rosmorduc O, Poupon R. Long term outcome and response to therapy of primary biliary cirrhosis-autoimmune hepatitis overlap syndrome. J Hepatol. 2006;44:400–406
  22. Poupon R, Chazouilleres O, Corpechot C, Chrétien Y. Development of autoimmune hepatitis in patients with typical primary biliary cirrhosis. Hepatology. 2006;44:85–90
  23. Silveira MG, Talwalkar JA, Angulo P, Lindor KD. Overlap of autoimmune hepatitis and primary biliary cirrhosis: long-term outcomes. Am J Gastroenterol. 2007;102:1244–1250
  24. Lööf L, Adami HO, Sparén P, Danielsson A, Eriksson LS, Hultcrantz R, et al. Cancer risk in primary biliary cirrhosis: a population-based study from Sweden. Hepatology. 1994;20:101–104

PII: S0953-6205(08)00342-7

doi: 10.1016/j.ejim.2008.12.011

European Journal of Internal Medicine
Volume 20, Issue 4 , Pages 398-402 , July 2009