European Journal of Internal Medicine
Volume 20, Issue 6 , Pages 654-659 , October 2009

Motilin concentrations in relation to gastro intestinal dysmotility in diabetes mellitus

  • Hillevi Pendleton

      Affiliations

    • Department of Oto-Rhino-Laryngology, Malmö University Hospital, Lund University, Sweden
  • ,
  • Rolf Ekman

      Affiliations

    • Institute of Clinical Neuroscience and Physiology, Gothenburg University, Sweden
  • ,
  • Rolf Olsson

      Affiliations

    • Department of Medical Radiology, Malmö University Hospital, Lund University, Sweden
  • ,
  • Olle Ekberg

      Affiliations

    • Department of Medical Radiology, Malmö University Hospital, Lund University, Sweden
  • ,
  • Bodil Ohlsson

      Affiliations

    • Department of Clinical Sciences, Gastroenterology Division, Malmö University Hospital, Lund University, Sweden
    • Corresponding Author InformationCorresponding author. Entrance 35, S-205 02 Malmö, Sweden. Tel.: +46 40 33 10 00; fax: +46 40 33 62 08.

Received 9 February 2009 ,Revised 21 April 2009 ,Accepted 30 May 2009.

References 

  1. Mitznegg P, Bloom SR, Christofides N, Besterman H, Domschke W, Domschke S, et al. Release of motilin in man. Scand J Gastroenterol. 1976;11(Suppl. 39):53–56
  2. Verh K. Motilin and motilin receptors: characterization and functional significance. Acad Geneeskd Belg. 2001;63:511–529
  3. Takeshita E, Matsuura B, Dong M, Miller LJ, Matsui H, Onji M. Molecular characterization and distribution of motilin family receptors in the human gastrointestinal tract. J Gastroenterol. 2006;41:223–230
  4. Vantrappen G, Janssens J, Peeters TL, Bloom SR, Christofides ND, Hellemans J. Motilin and the interdigestive migrating motor complex in man. Dig Dis Sci. 1979;24:497–500
  5. Tomita R, Tanjoh K, Munakata K. The role of motilin and cisapride in the enteric nervous system of the lower esophageal sphincter in humans. Surg Today. 1997;27:985–992
  6. Perdikis G, Wilson P, Hinder RA, Redmond EJ, Wetscher GJ, Saeki S, et al. Gastroesophageal reflux disease is associated with enteric hormone abnormalities. Am J Surg. 1994;167:186–192
  7. Gadenstätter M, Promegger R, Klingler A, Schwelberger H, Weiss HG, Glaser K, et al. Alterations of gut neuropeptides in gastroesophageal reflux disease are resolved after antireflux surgery. Am J Surg. 2000;180:483–487
  8. Pennathur A, Tran A, Cioppi M, Fayad J, Sieren GL, Little AG. Erythromycin strengthens the defective lower esophageal sphincter in patients with gastroesophageal reflux disease. Am J Surg. 1994;167:169–173
  9. Chrysos E, Tzovaras G, Epanomeritakis E, Tsiaoussis J, Vrachasotakis N, Vassilakis JS, et al. Erythromycin enhances oesphageal motility in patients with gastro-esophageal reflux. ANZ J Surg. 2001;71:98–102
  10. Erbas T, Varoglu E, Erbas B, Tastekin G, Akalin S. Comparison of metoclopramide and erythromycin in the treatment of diabetic gastroparesis. Diabet Care. 1993;16:1511–1514
  11. Faraj J, Melander O, Sundkvist G, Olsson R, Thorsson O, Ekberg O, et al. Oesophageal dysmotility, delayed gastric emptying and gastrointestinal symptoms in patients with diabetes mellitus. Diabet Med. 2007;24:1235–1239
  12. Ohlsson B, Melander O, Thorson O, Olsson R, Ekberg O, Sundkvist G. Oesophageal dysmotility, delayed gastric emptying and autonomic neuropathy correlate to disturbed glucose homeostasis. Diabetologia. 2006;49:2010–2014
  13. Spechler SJ, Castell DO. Classification of oesophageal motility abnormalities. Gut. 2001;49:145–151
  14. Collins PJ, Horowitz M, Cook DJ, Harding PE, Shearman DJ. Gastric emptying in normal subjects: a reproducible technique using a single scintillation camera and computer system. Gut. 1983;24:1117–1125
  15. Hanson M, Lilja B. Gastric emptying in smokers. Scand J Gastroenterol. 1987;22:1102–1104
  16. Sundkvist G, Almér L-O, Lilja B. Respiratory influence on heart rate in diabetes mellitus. Br Med J. 1979;1:924–925
  17. Forsen A, Kangro M, Sterner G, Norrgren K, Thorsson O, Wollmer P, et al. A 14-year prospective study of autonomic nerve function in type 1 diabetic patients: association with neuropathy. Diabet Med. 2004;21:852–858
  18. Caplin NJ, O'Leary P, Bulsara M, Davis EA, Jones TW. Subcutaneous glucose sensor values closely parallel blood glucose during insulin-induced hypoglycaemia. Diabet Med. 2003;238–241
  19. Ohlsson B, Forsling ML, Rehfeld JF, Sjölund K. Cholecystokinin stimulation leads to an increased oxytocin secretion in women. Eur J Surg. 2002;168:114–118
  20. Sjölund K, Ekman R, Lindgren S, Rehfeld J. Disturbed motilin and cholecystokinin in the irritable bowel disease. Scand J Gastroenterol. 1996;31:1110–1114
  21. Poitras P, Peeters TL. Motilin. Curr Opinion Endocrinol Diab Obesity. 2008;15:54–57
  22. Jenssen TG, Burhol PG, Jorde R, Florholmen J, Lygren I. Radioimmunoassayable plasma motilin in man. Secretagogues, insulin-induced suppression, renal removal, and plasma components. Scand J Gastroenterol. 1984;19:17–23
  23. Pennathur A, Cioppi M, Fayad JB, Little AG. Erythromycin, motilin, and the esophagus. Surgery. 1993;114:295–298[discussion 298–299]
  24. Koutsoumbi P, Epanomeritakis E, Tsiaoussis J, Athanasakis H, Chrysos E, Zoras O, et al. The effect of erythromycin on human esophageal motility is mediated by serotonin receptors. Am J Gastroenterol. 2000;95:3388–3392
  25. Netzer P, Schmitt B, Inauen W. Effects of ABT-229, a motilin agonist, on acid reflux, oesophageal motility and gastric emptying in patients with gastro-oesphageal reflux disease. Aliment Pharmacol Ther. 2002;16:1481–1490
  26. Achem-Karam SR, Funakoshi A, Vinik AI, Owyang C. Plasma motilin concentration and interdigestive migrating motor complex in diabetic gastroparesis: effect of metoclopramide. Gastroenterology. 1985;88:492–499
  27. Kawagishi T, Nishizawa Y, Okuno Y, Sekiya K, Morii H. Effect of cisapride on gastric emptying of indigestible solids and plasma motilin concentrations in diabetic autonomic neuropathy. Am J Gastroenterol. 1993;88:933–938
  28. Borg J, Melander O, Johansson L, Uvnäs-Moberg K, Rehfeldt JF, Ohlsson B. Gastroparesis is associated with oxytocin deficiency, oesophageal dysmotility with hyperCCKemia and autonomic neuropathy with hypergastrinemia. BMC Gastroenterology. 2009;9:17
  29. Jain NK, Boivin M, Zinsmeister AR, Brown ML, Malagelada JR, DiMagmo EP. Effect of ileal perfusion of carbohydrates and amylase inhibitor on gastrointestinal hormones and emptying. Gastroenterology. 1989;96:377–387
  30. Christofides ND, Long RG, Fitzpatrick ML, McGregor GP, Bloom SR. Effect of motilin on the gastric emptying of glucose and fat in humans. Gatsroenterology. 1981;80:456–460
  31. Talley NJ, Verlinden M, Geenen DJ, Hogan RB, Riff D, McCallum RW, et al. Effects of a motilin receptor agonist (ABT-229) on upper gastrointestinal symptoms in type 1 diabetes mellitus: a randomised, double blind, placebo controlled trial. Gut. 2001;49:395–401
  32. Russo A, Stevens JE, Giles N, Krause G, O'Donovan DG, Horowitz M, et al. Effect of the motilin agonist KC 11458 on gastric emptying in diabetic gastroparesis. Aliment Pharmacol Ther. 2004;20:333–338

PII: S0953-6205(09)00099-5

doi: 10.1016/j.ejim.2009.05.015

European Journal of Internal Medicine
Volume 20, Issue 6 , Pages 654-659 , October 2009