European Journal of Internal Medicine
Volume 21, Issue 2 , Pages 87-90 , April 2010

Relationship between anaemia and cognitive functions in elderly people

  • Hakan M. Terekeci

      Affiliations

    • Division of Internal Medicine, GATA Haydarpasa Training Hospital, Tıbbiye Caddesi TR-34668 Kadikoy-Istanbul, Turkey
    • Corresponding Author InformationCorresponding author. GATA Haydarpasa Training Hospital, Division of Internal Medicine, Tıbbiye Caddesi, TR-34668, Kadikoy-Istanbul, Turkey. Tel.: +90 216 542 2701; fax: +90 216 348 78 80.
  • ,
  • Yasar Kucukardali

      Affiliations

    • Division of Internal Medicine, GATA Haydarpasa Training Hospital, Tıbbiye Caddesi TR-34668 Kadikoy-Istanbul, Turkey
  • ,
  • Yalcin Onem

      Affiliations

    • Division of Internal Medicine, GATA Haydarpasa Training Hospital, Tıbbiye Caddesi TR-34668 Kadikoy-Istanbul, Turkey
  • ,
  • Alev Akyol Erikci

      Affiliations

    • Division of Hematology, GATA Haydarpasa Training Hospital, Tıbbiye Caddesi TR-34668 Kadikoy-Istanbul, Turkey
  • ,
  • Betul Kucukardali

      Affiliations

    • Department of Psychology, Dogus University – Istanbul, Turkey
  • ,
  • Burak Sahan

      Affiliations

    • Division of Internal Medicine, GATA Haydarpasa Training Hospital, Tıbbiye Caddesi TR-34668 Kadikoy-Istanbul, Turkey
  • ,
  • Ozkan Sayan

      Affiliations

    • Division of Hematology, GATA Haydarpasa Training Hospital, Tıbbiye Caddesi TR-34668 Kadikoy-Istanbul, Turkey
  • ,
  • Serkan Celik

      Affiliations

    • Division of Internal Medicine, GATA Haydarpasa Training Hospital, Tıbbiye Caddesi TR-34668 Kadikoy-Istanbul, Turkey
  • ,
  • Mahir Gulec

      Affiliations

    • Public Health Department, Gülhane Military Medical Academy, TR-06018, Etlik, Ankara, Turkey
  • ,
  • Yavuz S. Sanisoglu

      Affiliations

    • Department of Monitoring and Evaluation, Turkish Ministry of Health, Sihhiye, Ankara, Turkey
  • ,
  • Selim Nalbant

      Affiliations

    • Division of Internal Medicine, GATA Haydarpasa Training Hospital, Tıbbiye Caddesi TR-34668 Kadikoy-Istanbul, Turkey
  • ,
  • Cihan Top

      Affiliations

    • Division of Internal Medicine, GATA Haydarpasa Training Hospital, Tıbbiye Caddesi TR-34668 Kadikoy-Istanbul, Turkey
  • ,
  • Cagatay Oktenli

      Affiliations

    • Division of Internal Medicine, GATA Haydarpasa Training Hospital, Tıbbiye Caddesi TR-34668 Kadikoy-Istanbul, Turkey

Received 1 April 2009 ,Revised 29 November 2009 ,Accepted 4 December 2009.

References 

  1. Lloyd-Sherlock P. Population aging in developed and developing regions: implications for health policy. Soc Sci Med. 2000;51:887–895
  2. Stuck EA, Egger M, Hammer A, Minder CE, Beck JC. Home visits to prevent nursing home admission and functional decline in elderly people. J Am Med Assoc. 2002;87:1022–1028
  3. Samuel O. An evidence-based approach to assessing older people in primary care (Book review). Fam Pract. 2002;19:568–569
  4. Skelton DA, Greig CA, Davies JM, Young A. Strength, power and related functional ability of healthy people aged 65–89years. Age Ageing. 1994;23:371–377
  5. Moron C, Viteri FE. Update on common indicators of nutritional status: food access, food consumption, and biochemical measures of iron and anemia. Nutr Rev. 2009;67:S31–S35
  6. Gabrilove J. Anemia and the elderly: clinical considerations. Best Pract Res Clin Haematol. 2005;18(3):417–422
  7. Andres E, Federici L, Serraj K, Kaltenbach G. Update of nutrient-deficiency anemia in elderly patients. Eur J Intern Med. 2008;19:488–493
  8. Lash AA, Coyer SM. Anemia in older adults. Medsurg Nurs. 2008;17:298–304
  9. Beghe C, Wilson A, Ershler W. Prevalence and outcomes of anemia in geriatrics a systematic review of the literature. Am J Med. 2004;16:3–10
  10. Beard CM, Kokmen E, O'Brien PC, Anía BJ, Melton LJ. Risk of Alzheimer's disease among elderly patients with anemia: population-based investigations in Olmsted Country. Minnesota Ann Epidemiol. 1997;7:219–224
  11. Argyriadou S, Vlachoinikolis I, Melisopoulou H, Katachanakis K, Lionis C. In what extent anemia coexist with cognitive impairment in elderly: a cross-sectional study in Greece. BMC Family Practice. 2001;2:5
  12. Elwood PC, Pickering J, Gallacher JEJ. Cognitive function and blood rheology: results from the Caerphilly cohort of older men. Age Ageing. 2001;30:135–139
  13. Zamboni V, et al. Anemia and cognitive performance in hospitalized older patients: results from the GIFA study. Int J Geriatr Psychiatry. 2006;21:529–534
  14. Atti AR, Palmer K, Volpato S, Zuliani G, Winblad B, Fratiglioni L. Anemia increases the risk of dementia in cognitively intact elderly. Neurobiol Aging. 2006;27:278–284
  15. Denny SD, Kuchibhatla MN, Cohen HJ. Impact of anemia on mortality, cognition, and function in community-dwelling elderly. Am J Med. 2006;119:327–334
  16. Schmidt R, Schmidt H, Curb DJ, Masaki K, White KL, Launer LJ. Early inflammation and dementia: a 25-year follow up of the Honolulu–Asia Aging Study. Ann Neurol. 2002;52(2):168–174
  17. Pieroni L, Foglietti MJ, Andreux JP, Albou D, Nafziger J. Factors involved in the anemia of chronic disorders in elderly patients. Gerontology. 1997;43:326–334
  18. Wang SY. Weight loss and metabolic changes in dementia. J Nutr Health Aging. 2002;6:201–205
  19. Katz SC, Stroud MW. Functional assessment in geriatrics: a review of progress and directions. J Am Geriatr Soc. 1989;37:267–271
  20. Folstein MF, Folstein SE, McHugh PR. Mini-mental state. A practical method for grading the cognitive state of patients for the clinician. J Psychiatry Res. 1975;12:189–198
  21. World Health Organization. Obesity: preventing and managing the global epidemic. Report on a consultative meeting. Geneva: World Health Organization; 1997;
  22. Beard C, Kokmen E, O'Brien P, Ania B, Melton J. Risk of Alzheimer disease among elderly patients with anemia: population based investigation in Olmsted County. Minnesota Ann Epidemiol. 1997;7:219–224
  23. Ng TP, Feng L, Niti M, Yap KB. Albumin, haemoglobin, BMI and cognitive performance in older adults. Age Ageing. 2008;37(4):423–429
  24. Cesari M, et al. Hemoglobin levels and skeletal muscle: results from the InCHIANTI study. J Gerontol A Biol Sci Med Sci. 2004;59:238–241
  25. Croughwell ND, et al. Jugular bulb saturation and cognitive dysfunction after cardiopulmonary bypass. Ann Thorac Surg. 1994;58(6):1702–1708
  26. Kamenetz Y, et al. Relationship between routine hematological parameters, serum IL-3, IL-6 and erythropoietin and mild anemia and degree of function in the elderly. Aging (Milano). 1998;10:32–38
  27. Penninx BW, et al. Anemia is associated with disability and decreased physical performance and muscle strength in the elderly. J Am Geriatr Soc. 2004;52:719–724
  28. Shah RC, et al. Relation of hemoglobin to level of cognitive function in older persons. Neuroepidemiology. 2008;32(1):40–46
  29. Kalantar-Zadeh K, et al. Malnutrition inflammation complex syndrome in dialysis patients: causes and consequences. Am J Kidney Dis. 2003;42:864–881
  30. Carlson JE, et al. Measuring fragility in the hospitalized elderly concept of functional homeostasis. Am J Phys Rehabil. 1998;77:252–257
  31. Maraldi C, et al. Anemia and recovery from disability in activities of daily living in hospitalized older persons. J Am Geriatr Soc. 2006;54:632–636

PII: S0953-6205(09)00248-9

doi: 10.1016/j.ejim.2009.12.005

European Journal of Internal Medicine
Volume 21, Issue 2 , Pages 87-90 , April 2010