European Journal of Internal Medicine
Volume 21, Issue 2 , Pages 114-117 , April 2010

Low prevalence of anti-RNA polymerase III antibodies in a French scleroderma population: Anti-RNA polymerase III scleroderma

  • Benoit Faucher

      Affiliations

    • Service de Médecine Interne, Hôpital Nord, Assistance Publique-Hôpitaux de Marseille (AP-HM), Université de la Méditerranée, 13015 Marseille, France
    • Benoit Faucher and Philippe Stein equally contributed to this work.
    • Benoit Faucher, Brigitte Granel, Pierre-Jean Weiller, Patrick Disdier, Jacques Serratrice, Jean Robert Harlé, Jean Marc Durand, Yves Frances, Sandrine Guis, Thao Pham, Nathalie Bardin and Marielle Sanmarco have all contributed to the intellectual planning of the project.
    • Benoit Faucher, Brigitte Granel, Nathalie Bardin and Marielle Sanmarco have contributed to the intellectual analysis of the data and writing of the paper.
    • ,
  • Philippe Stein

      Affiliations

    • Laboratoire d'Immunologie, Hôpital de la Conception, Assistance Publique-Hôpitaux de Marseille (AP-HM), Université de la Méditerranée, 13005 Marseille, France
    • Benoit Faucher and Philippe Stein equally contributed to this work.
    • Philippe Stein and Nathalie Bardin carried out the experimental work.
    • ,
  • Brigitte Granel

      Affiliations

    • Service de Médecine Interne, Hôpital Nord, Assistance Publique-Hôpitaux de Marseille (AP-HM), Université de la Méditerranée, 13015 Marseille, France
    • Corresponding Author InformationCorresponding author. Service de Médecine Interne, Hôpital Nord, AP-HM, Université de la Méditerranée Marseille, France. Tel.: +33 4 91 96 87 11; fax: +33 4 91 96 80 80.
    • Benoit Faucher, Brigitte Granel, Pierre-Jean Weiller, Patrick Disdier, Jacques Serratrice, Jean Robert Harlé, Jean Marc Durand, Yves Frances, Sandrine Guis, Thao Pham, Nathalie Bardin and Marielle Sanmarco have all contributed to the intellectual planning of the project.
    • Benoit Faucher, Brigitte Granel, Nathalie Bardin and Marielle Sanmarco have contributed to the intellectual analysis of the data and writing of the paper.
    • ,
  • Pierre-Jean Weiller

      Affiliations

    • Service de Médecine Interne, Hôpital de la Timone, Assistance Publique-Hôpitaux de Marseille (AP-HM), Université de la Méditerranée, 13005 Marseille, France
    • Benoit Faucher, Brigitte Granel, Pierre-Jean Weiller, Patrick Disdier, Jacques Serratrice, Jean Robert Harlé, Jean Marc Durand, Yves Frances, Sandrine Guis, Thao Pham, Nathalie Bardin and Marielle Sanmarco have all contributed to the intellectual planning of the project.
    • ,
  • Patrick Disdier

      Affiliations

    • Service de Médecine Interne, Hôpital de la Timone, Assistance Publique-Hôpitaux de Marseille (AP-HM), Université de la Méditerranée, 13005 Marseille, France
    • Benoit Faucher, Brigitte Granel, Pierre-Jean Weiller, Patrick Disdier, Jacques Serratrice, Jean Robert Harlé, Jean Marc Durand, Yves Frances, Sandrine Guis, Thao Pham, Nathalie Bardin and Marielle Sanmarco have all contributed to the intellectual planning of the project.
    • ,
  • Jacques Serratrice

      Affiliations

    • Service de Médecine Interne, Hôpital de la Timone, Assistance Publique-Hôpitaux de Marseille (AP-HM), Université de la Méditerranée, 13005 Marseille, France
    • Benoit Faucher, Brigitte Granel, Pierre-Jean Weiller, Patrick Disdier, Jacques Serratrice, Jean Robert Harlé, Jean Marc Durand, Yves Frances, Sandrine Guis, Thao Pham, Nathalie Bardin and Marielle Sanmarco have all contributed to the intellectual planning of the project.
    • ,
  • Jean Robert Harlé

      Affiliations

    • Service de Médecine Interne, Hôpital de la Conception, Assistance Publique-Hôpitaux de Marseille (AP-HM), Université de la Méditerranée, 13005 Marseille, France
    • Benoit Faucher, Brigitte Granel, Pierre-Jean Weiller, Patrick Disdier, Jacques Serratrice, Jean Robert Harlé, Jean Marc Durand, Yves Frances, Sandrine Guis, Thao Pham, Nathalie Bardin and Marielle Sanmarco have all contributed to the intellectual planning of the project.
    • ,
  • Jean Marc Durand

      Affiliations

    • Service de Médecine Interne, Hôpital de la Conception, Assistance Publique-Hôpitaux de Marseille (AP-HM), Université de la Méditerranée, 13005 Marseille, France
    • Benoit Faucher, Brigitte Granel, Pierre-Jean Weiller, Patrick Disdier, Jacques Serratrice, Jean Robert Harlé, Jean Marc Durand, Yves Frances, Sandrine Guis, Thao Pham, Nathalie Bardin and Marielle Sanmarco have all contributed to the intellectual planning of the project.
    • ,
  • Yves Frances

      Affiliations

    • Service de Médecine Interne, Hôpital Nord, Assistance Publique-Hôpitaux de Marseille (AP-HM), Université de la Méditerranée, 13015 Marseille, France
    • Benoit Faucher, Brigitte Granel, Pierre-Jean Weiller, Patrick Disdier, Jacques Serratrice, Jean Robert Harlé, Jean Marc Durand, Yves Frances, Sandrine Guis, Thao Pham, Nathalie Bardin and Marielle Sanmarco have all contributed to the intellectual planning of the project.
    • ,
  • Sandrine Guis

      Affiliations

    • Service de Rhumatologie, Hôpital de la Conception, Assistance Publique-Hôpitaux de Marseille (AP-HM), Université de la Méditerranée, 13005 Marseille, France
    • Benoit Faucher, Brigitte Granel, Pierre-Jean Weiller, Patrick Disdier, Jacques Serratrice, Jean Robert Harlé, Jean Marc Durand, Yves Frances, Sandrine Guis, Thao Pham, Nathalie Bardin and Marielle Sanmarco have all contributed to the intellectual planning of the project.
    • ,
  • Thao Pham

      Affiliations

    • Service de Rhumatologie, Hôpital de la Conception, Assistance Publique-Hôpitaux de Marseille (AP-HM), Université de la Méditerranée, 13005 Marseille, France
    • Benoit Faucher, Brigitte Granel, Pierre-Jean Weiller, Patrick Disdier, Jacques Serratrice, Jean Robert Harlé, Jean Marc Durand, Yves Frances, Sandrine Guis, Thao Pham, Nathalie Bardin and Marielle Sanmarco have all contributed to the intellectual planning of the project.
    • ,
  • Nathalie Bardin

      Affiliations

    • Laboratoire d'Immunologie, Hôpital de la Conception, Assistance Publique-Hôpitaux de Marseille (AP-HM), Université de la Méditerranée, 13005 Marseille, France
    • Benoit Faucher, Brigitte Granel, Pierre-Jean Weiller, Patrick Disdier, Jacques Serratrice, Jean Robert Harlé, Jean Marc Durand, Yves Frances, Sandrine Guis, Thao Pham, Nathalie Bardin and Marielle Sanmarco have all contributed to the intellectual planning of the project.
    • Benoit Faucher, Brigitte Granel, Nathalie Bardin and Marielle Sanmarco have contributed to the intellectual analysis of the data and writing of the paper.
    • Philippe Stein and Nathalie Bardin carried out the experimental work.
    • ,
  • Marielle Sanmarco

      Affiliations

    • Laboratoire d'Immunologie, Hôpital de la Conception, Assistance Publique-Hôpitaux de Marseille (AP-HM), Université de la Méditerranée, 13005 Marseille, France
    • Benoit Faucher, Brigitte Granel, Pierre-Jean Weiller, Patrick Disdier, Jacques Serratrice, Jean Robert Harlé, Jean Marc Durand, Yves Frances, Sandrine Guis, Thao Pham, Nathalie Bardin and Marielle Sanmarco have all contributed to the intellectual planning of the project.
    • Benoit Faucher, Brigitte Granel, Nathalie Bardin and Marielle Sanmarco have contributed to the intellectual analysis of the data and writing of the paper.

Received 25 November 2009 ,Revised 31 December 2009 ,Accepted 7 January 2010.

References 

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  8. Kuwana M, Okano Y, Kaburaki J, Tojo T, Medsger TA. Racial differences in the distribution of systemic sclerosis-related serum antinuclear antibodies. Arthritis Rheum. 1994;37:902–906
  9. Kuwana M, Okano Y, Pandey JP, Silver RM, Fertig N, Medsger TA. Enzyme-linked immunosorbent assay for detection of anti-RNA polymerase III antibody: analytical accuracy and clinical associations in systemic sclerosis. Arthritis Rheum. 2005;52:2425–2432
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  13. Chang M, Wang RJ, Yangco DT, et al. Analysis of autoantibodies against RNA polymerases using immunoaffinity-purified RNA polymerase I, II, and III antigen in an enzyme-linked immunosorbent assay. Clin Immunol Immunopathol. 1998;89:71–78
  14. Meyer OC, Fertig N, Lucas M, Somogyi N, Medsger TA. Disease subsets, antinuclear antibody profile, and clinical features in 127 French and 247 US adult patients with systemic sclerosis. J Rheumatol. 2007;34:104–109
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  18. Codullo V, Morozzi G, Bardoni A, et al. Validation of a new immunoenzymatic method to detect antibodies to RNA polymerase III in systemic sclerosis. Clin Exp Rheumatol. 2007;25:373–377
  19. Bardoni A, Rossi P, Salvini R, Bobbio-Pallavicini F, Caporali R, Montecucco C. Autoantibodies to RNA-polymerases in Italian patients with systemic sclerosis. Clin Exp Rheumatol. 2003;21:301–306
  20. Kuwana M, Pandey JP, Silver RM, Kawakami Y, Kaburaki J. HLA class II alleles in systemic sclerosis patients with anti-RNA polymerase I/III antibody: associations with subunit reactivities. J Rheumatol. 2003;30:2392–2397
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PII: S0953-6205(10)00007-5

doi: 10.1016/j.ejim.2010.01.004

European Journal of Internal Medicine
Volume 21, Issue 2 , Pages 114-117 , April 2010

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