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Editorial Board
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i
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Contents
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iii-iv
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| Review articles |
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Matrix metalloproteinases in metabolic syndrome
14 October 2011
Abstract: Metabolic syndrome is commonly accompanied by an elevated cardiovascular risk with high morbidity and mortality. The alterations of the arterial vasculature begin with endothelial dysfunctio...
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E. Hopps,
G. Caimi
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99-104
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On the nature of sarcoidosis
13 October 2011
Abstract: More than 140years since its recognition as a clinical entity, sarcoidosis remains enigmatic. Its classification as a disease vs. a syndrome is uncertain. Its etiology remains undefined. The...
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Jerome M. Reich
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105-109
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Excessive daytime sleepiness and narcolepsy — An approach to investigation and management
31 October 2011
Abstract: Excessive daytime sleepiness is a common presentation to physicians both in general practice and hospital settings. In this review, we provide an update on the latest theories on the pathoge...
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Ian Morrison,
Renata L. Riha
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110-117
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The frailty dilemma. Review of the predictive accuracy of major frailty scores
03 October 2011
Abstract: Background: To identify frail elderly individuals, several index or scoring systems have been developed for research purposes. The practical value of these scores for screening and diagnosti...
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Evelien Pijpers,
Isabel Ferreira,
Coen D.A. Stehouwer,
Arie C. Nieuwenhuijzen Kruseman
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118-123
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Prevention of delirium in demented hospitalized patients
23 June 2011
Delirium, defined as an acute disruption of attention and cognition, has been recognized as the most common complication of hospitalisation for old people, occurring in 6 to 56% of the medical in-pati...
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Marion Andro,
Emmanuelle Comps,
Sandrine Estivin,
Armelle Gentric
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124-125
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| Debate |
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Dipeptidylpeptidase-4 (DPP-4) inhibitors are favourable to glucagon-like peptide-1 (GLP-1) receptor agonists: Yes
16 November 2011
Abstract: The pharmacological treatment of type 2 diabetes (T2DM) is becoming increasingly complex, especially since the availability of incretin-based therapies. Compared with other glucose-lowering ...
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André J. Scheen
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126-131
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Dipeptidyl peptidase-4 (DPP-4) inhibitors are favourable to Glucagon-Like Peptide-1 (GLP-1) agonists: No
02 December 2011
Abstract: Incretin-based therapies, which include the GLP-1 receptor agonists and DPP-4 inhibitors, use the antidiabetic properties of potentiating the GLP-1 receptor signalling via the regulation of ...
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Sten Madsbad
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132-136
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| Original articles |
| Endocrinology |
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The association of physical activity with novel adipokines in patients with type 2 diabetes
30 November 2011
Abstract: Background: Adipose-tissue derivatives, known as adipokines, have been involved in the inflammatory-mediated metabolic and cardiovascular disorders of type 2 diabetes mellitus (T2DM). This s...
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Nikolaos P.E. Kadoglou,
Ioannis S. Vrabas,
Alkistis Kapelouzou,
Nikoletta Angelopoulou
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137-142
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Quality of life in type 2 diabetes mellitus after a very low calorie diet and exercise
18 August 2011
Abstract: Objective: To evaluate whether the addition of exercise to a very low calorie diet (VLCD) has beneficial short- and long-term effects on health-related quality of life (QoL) in obese patient...
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Marieke Snel,
Maria A. Sleddering,
Inge D. vd Peijl,
Johannes A. Romijn,
Hanno Pijl,
A. Edo Meinders,
Ingrid M. Jazet
et al.
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143-149
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Erythrocyte mechanical fragility is increased in patients with type 2 diabetes
02 December 2011
Abstract: Background: Anemia is common among patients with type 2 diabetes. We determined whether type 2 diabetic patients significantly differed in erythrocyte mechanical fragility as compared with n...
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Giuseppe Lippi,
Mariella Mercadanti,
Rosalia Aloe,
Giovanni Targher
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150-153
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| Haemotology |
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Anemia as a risk factor for low bone mineral density in postmenopausal Turkish women
12 December 2011
Abstract: Background: We investigated the association of bone mineral density (BMD) by detected dual-energy X-ray absorptiometric (DXA) method and hemoglobin (Hb) levels in a large sample. Methods: Th...
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Ugur Korkmaz,
Nurdan Korkmaz,
Selma Yazici,
Melih Erkan,
Ali Erdem Baki,
Mehmet Yazici,
Hakan Ozhan,
Safinaz Ataoğlu
et al.
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154-158
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Quick diagnosis units or conventional hospitalisation for the diagnostic evaluation of severe anaemia: A paradigm shift in public health systems?
14 March 2011
Abstract: Background: Acute hospital bed utilisation is a growing concern for health care systems in most countries with public health models, as it represents a significant share of health costs. Ana...
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Xavier Bosch,
Frank Palacios,
Gabriel Inclán-Iríbar,
Marta Castañeda,
Anna Jordán,
Pedro Moreno,
Antonio Coca,
Alfonso López-Soto
et al.
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159-164
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| Gastroenterology and hepatology |
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Comparison of levofloxacin-containing sequential and standard triple therapies for the eradication of Helicobacter pylori
21 March 2011
Abstract: Background: There is an important concern about the success of standard triple treatment for Helicobacter pylori (H. pylori) in recent years. Better eradication rates have been reported with...
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Zulfikar Polat,
Abdurrahman Kadayifci,
Murat Kantarcioglu,
Ayhan Ozcan,
Ozdes Emer,
Ahmet Uygun
et al.
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165-168
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| Vascular medicine and cardiology |
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Growth differentiation factor-15, a novel biomarker related with disease severity in patients with hypertrophic cardiomyopathy
19 September 2011
Abstract: Background: The growth differentiation factor 15 (GDF-15) has been shown up-regulated in stress conditions and to have regulatory actions in myocyte hypertrophy. We hypothesized that GDF-15 ...
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Silvia Montoro-García,
Diana Hernández-Romero,
Eva Jover,
Antonio García-Honrubia,
Juan A. Vilchez,
Teresa Casas,
Pedro Martínez,
Vicente Climent,
Luis Caballero,
Mariano Valdés,
Francisco Marín
et al.
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169-174
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Association between the polymorphism of estrogen receptor α and coronary artery disease in a Chinese population
13 June 2011
Abstract: Background: The role of estrogen receptor α (ERα) polymorphism in coronary artery disease (CAD) was investigated previously in several populations. There are few data on relation between ERa...
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Cheng Shen,
Jianming Chen,
Shizhi Fan,
Zhipin Li,
Yijie Hu,
Qianjin Zhong
et al.
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175-178
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| General internal medicine |
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Effects of renin–angiotensin blockers/inhibitors and statins on mortality and functional impairment in polypathological patients
11 July 2011
Abstract: Background: Frail and polypathological patients (PP) are often undertreated with evidence-based cardiovascular drugs, as their benefits are uncertain in this population. Objectives: To deter...
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Javier Galindo-Ocaña,
Máximo Bernabeu-Wittel,
Francesc Formiga,
Aurelio Fuertes-Martín,
Bosco Barón-Franco,
José Manuel Murcia-Zaragoza,
Lourdes Moreno-Gaviño,
Manuel Ollero-Baturone,
PROFUND Project researchers
et al.
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179-184
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Routinely adding ultrasound examinations by pocket-sized ultrasound devices improves inpatient diagnostics in a medical department
11 November 2011
Abstract: Background: We aimed to investigate the potential benefit of adding a routine cardiac and abdominal diagnostic examination by pocket-sized ultrasound device in patients admitted to a medical...
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Ole Christian Mjolstad,
Havard Dalen,
Torbjorn Graven,
Jens Olaf Kleinau,
Oyvind Salvesen,
Bjorn Olav Haugen
et al.
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185-191
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An observational study on bloodstream extended-spectrum beta-lactamase infection in critical care unit: Incidence, risk factors and its impact on outcome
01 August 2011
Abstract: Background: The incidence of nosocomial infections caused by extended-spectrum beta-lactamase (ESBL) producing microbes is increasing rapidly in the last few years. However, the clinical sig...
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Prashant Nasa,
Deven Juneja,
Omender Singh,
Rohit Dang,
Akhilesh Singh
et al.
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192-195
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Serum osmolarity as an outcome predictor in hospital emergency medical admissions
03 August 2011
Abstract: Background: To determine whether the serum osmolarity, calculated at the time of an emergency medical presentation, alone or combined with other predictors, could identify patients at low an...
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Trevor Nicholson,
Kathleen Bennett,
Bernard Silke
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e39-e43
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Prevalence of thoracic vertebral fractures in Spanish patients hospitalized in Internal Medicine Departments. Assessment of the clinical inertia. (PREFRAMI study)
23 December 2011
Abstract: Purpose: To study the prevalence of vertebral fractures (VF), the associated risk factors and the degree of diagnosis and prescription upon discharge in a series of hospitalized medical pati...
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S. Santamaría Fernández,
F. Miralles,
A. Ruiz Serrato,
J. García Alegría,
A. Ruiz Cantero,
M.A. García Ordoñez,
C.M. San Román Terán,
E. González Zorzano,
R. Gómez-Huelgas
et al.
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e44-e47
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The prevalence of Neurally Mediated Syncope in older patients presenting with unexplained falls
21 November 2011
Abstract: Aims: To determine the prevalence and clinical significance of carotid sinus syndrome (CSS) and vasovagal syncope (VVS), the two common types of Neurally Mediated Syncope (NMS), in a cohort ...
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Mahesan Anpalahan,
Stephen Gibson
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e48-e52
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Emergency visits and hospital admissions in aged people living close to a gas-fired power plant
24 October 2011
Abstract: Background: Combustion of natural gas for energy generation produces less pollutants than coke/oil. However, little is known about the short-term effect of pollution generated by gas-fired p...
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Agostino Di Ciaula
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e53-e58
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| Oncology |
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Human papillomavirus detected in esophageal squamous cell carcinoma in Iran
14 November 2011
Abstract: Introduction: Considering the different results obtained regarding the association of HPV with the development of esophageal squamous cell carcinoma (ESCC) in different populations, we aimed...
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Afshin Abdirad,
Neda Eram,
Ashkan Heshmatzade Behzadi,
Chihaya Koriyama,
Nima Parvaneh,
Suminori Akiba,
Takuya Kato,
Noureen Kahn,
Mohiedean Ghofrani,
Nader Sadigh
et al.
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e59-e62
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| Clinical pharmacology and toxicology |
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Countering health threats by chemicals with a potential terrorist background — creating a rapid alert system for Europe
28 October 2011
Abstract: Background: The acronym "ASHT" stands for "Alerting System and Development of a Health Surveillance System for the Deliberate Release of Chemicals by Terrorists". Imagine this scenario: 15 p...
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A. Schaper,
H. Desel,
S. Wyke,
R. Orford,
M.R. Griffiths,
N. Edwards,
H. Kupferschmidt,
M. Mathieu,
D. Pelclova,
R. Duarte-Davidson
et al.
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e63-e66
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| Letters to the Editor |
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Vitamin D deficiency and peripheral diabetic neuropathy
12 December 2011
Vitamin D deficiency has been associated with musculoskeletal diseases for many years. Accumulating evidence suggests that low Vitamin D levels are also associated with numerous pathologies such as ca...
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S. Skalli,
M. Muller,
S. Pradines,
S. Halimi,
N. Wion-Barbot
et al.
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e67-e68
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Vaccination against influenza a virus (H1N1) among Spanish healthcare workers
23 December 2011
After the first cases of H1N1 influenza A in 2009, the World Health Organization recommended the vaccination of healthcare workers (HCWs) as a matter of priority . HCWs are at occupational risk of inf...
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Julián Olalla,
Fernando de Ory,
Inmaculada Casas,
Nicolás Benítez
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e69-e70
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Initiation treatment with imiglucerase every 3 weeks in type 1 Gaucher disease
23 December 2011
Gaucher disease (GD) is a rare autosomal recessive disorder due to deficit of glucocerebrosidase . GD type 1 (GD1) is defined by the occurrence of haematological, visceral and bone signs but without n...
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Christine Serratrice,
Laure Swiader,
Jacques Serratrice,
Pierre Jean Weiller,
Denis Verrot
et al.
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e71-e72
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Bed-blockers: An 8year experience of clinical management
08 December 2011
Bed-blockers and excessive rehospitalizations are serious problems in hospitals . Some countries have outlined strategies to limit this phenomenon. Sometimes a hospital stay reduction has led to an in...
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Tiziana Meschi,
Antonio Nouvenne,
Marcello Maggio,
Fulvio Lauretani,
Loris Borghi
et al.
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e73-e74
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