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The beneficial effect of acute phase increase in serum ferritin

  • Jecko Thachil
    Correspondence
    Department of Haematology, Central Manchester University Hospitals NHS Foundation Trust, Oxford Road, Manchester M13 9WL, United Kingdom. Fax: +44 161 276 8085.
    Affiliations
    Department of Haematology, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom
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Published:August 01, 2016DOI:https://doi.org/10.1016/j.ejim.2016.07.020
      It is well-known that serum ferritin levels increase as an acute phase reactant. In patients who have infections or inflammatory states, the levels of ferritin can go up several-fold. However, what has not been understood is why this phenomenon occurs, if it has any physiological basis and if this evolutionary mechanism is of benefit to the host?

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