Abstract
Systemic lupus erythematosus is an autoimmune and inflammatory disease characterized
by a variety of symptoms, including arthropathy. The clinical presentation of joint
involvement varies, ranging from arthralgia without erosions or deformity to an erosive
arthropathy and severe functional disability. This paper reviews the main forms of
deforming arthropathy observed in lupus patients. It includes a) non-erosive arthropathy
(it is the most frequent form and characterized as Jaccoud's), b) erosive symmetrical
polyarthritis with deformities similar to rheumatoid arthritis, named as rhupus, and
c) mild deforming arthropathy. Even though enough such cases of patients have been
reported in the international bibliography, no definite criteria for their diagnosis
have been published yet. The use of contemporary radiological and immunological methods
will facilitate their prevention and treatment.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to European Journal of Internal MedicineAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Common variable immunodeficiency in systemic lupus erythematosus.Semin Arthritis Rheum. 2007; 36: 238-245
- Lupus arthropathy: historical evolution from deforming arthritis to rhupus.Clin Rheumatol. 2004; 23: 523-526
- Lupus arthropathy: a case series of patients with rhupus.Clin Rheumatol. 2006; 25: 164-167
- Jaccoud's arthropathy in systemic lupus erythematosus: differentiation of deforming and erosive patterns by magnetic resonance imaging.Arthritis & Rheymatism. 2003; 48: 157-165
- Clinical features of systemic lupus erythematosus.in: Kelley W.N. Harris E.D. Ruddy S. Sledge C.B. Textbook of rheumatology. WB Saunders, Philadelphia1981
- Articular manifestations of systemic lupus erythematosus.in: Lahita R.G. Systemic lupus erythematosus. John Wiley and Sons, New York1987
- Musculoskeletal manifestations of systemic lupus erythematosus.Rheum Dis Clin North Am. 1988; 14: 99-116
- Bacterial monarthritis due to Neisseria meningitidis in systemic lupus erythematosus.J Rheumatol. 1981; 8: 145-148
- Deforming arthropathy or lupus and rhupus hands in systemic lupus erythematosus.Ann Rheum Dis. 1998; 57: 540-544
- Systemic lupus erythematosus.in: Kasper D. Fauci A. Longo D. Braunwld E. Hauser S. Jameson J.F. Harrison's principles of internal medicine. 16th edn. McGraw-Hill Companies, 2005: 1962
- Deforming arthropathy of the hands in systemic lupus erythematosus.J Rheumatol. 1988; 15: 65-69
- Jaccoud's syndrome: a sequel to the joint involvement of systemic lupus erythematosus.Clin Rheumatol Dis. 1975; 1: 125-148
- Radiographic findings in the hands in patients with systemic lupus erythematosus.Radiology. 1978; 126: 313-317
- Patients with systemic lupus erythematosus and Jaccoud's arthropathy: a clinical subset with an increased C-reactive protein response?.Ann Rheum Dis. 1992; 51: 358-361
- C-reactive protein in systemic lupus erythematosus.Clin rheumatol Dis. 1982; 8: 91-103
- C-reactive protein in sera from patients with systemic lupus erythematosus.J Rheumatol. 1981; 8: 599-604
- Deforming non-erosive arthritis of the hands in chronic systemic lupus erythematosus (SLE).Arthritis Rheum. 1970; 13: 329-330
- The hand in systemic lupus erythematosus.J Bone Jt Surg (Am). 1974; 56: 1207-1215
- Systemic lupus erythematosus.in: Beeson P.B. McDermott W. Cecil-loeb textbook of medicine. 13th edn. WB Saunders, Philadelphia1971: 821
- Clinical and immunogenetic characterization of Mexican patients with ‘rhupus’.Lupus. 2002; 11: 287-292
- Influence of hormonal events on disease expression in patients with the combination of systemic lupus erythematosus and rheumatoid arthritis.J Clin Rheumatol. 1999; 5: 9-16
- Are rheumatoid arthritis and systemic lupus erythematosus inversely related disease?.Med Hypotheses. 1985; 18: 377-386
- Erosive arthritis in systemic lupus erythematosus: analysis of a distinct clinical and serological subset.Br J Rheumatol. 1998; 37: 421-424
- Arthropathy of hands and feet in systemic lupus erythematosus.J Rheumatol. 1990; 17: 777-784
- Magnetic resonance imaging and miniarthroscopy of metacarpophalangeal joints: sensitive detection of morphologic changes in rheumatoid arthritis.Arthritis Rheum. 2001; 44: 2492-2502
- Hand arthritis in systemic lupus erythematosus: an ultrasound pictorial essay.Lupus. 2006; 15: 501-506
- Lesions of joints and tendon sheaths in systemic lupus erythematosus.Ann Rheum Dis. 1959; 18: 111-119
- Early undifferentiated connective tissue disease. IV. Musculoskeletal manifestations in a large cohort of patients with undifferentiated connective tissue diseases compared with cohorts of patients with well-established connective tissue diseases: follow up analyses in patients with unexplained polyarthritis and patients with rheumatoid arthritis at baseline.Arthritis Rheum. 1996; 39: 403-414
- Chronic urticarial-like lesions in systemic lupus erythematosus.Arch Dermatol. 1978; 114: 879-883
- Presence of antibodies against cyclic citrullinated paptides in patients with ‘rhupus’: a cross-sectional study.Arthritis Res Therapy. 2006; 8: R144
- Deforming arthropathy of the hands in systemic lupus erythematosus is associated with antibodies to SSA/Ro and to SSB/La.Lupus. 1994; 395: 419-422
- Jaccoud's syndrome: a nasographic entity associated with SLE.J Rheumatol. 1980; 7: 169-177
- Jaccoud's arthropathy: case report and necropsy study.Ann Rheum Dis. 1978; 37: 561-565
- Rhupus syndrome.Arch Intern Med. 1988; 148: 1633-1636
- The relation between heart and joint disease (type Jaccoud's).Br Heart J. 1950; 12: 101-131
- The interaction of soluble immune complexes with rheumatoid factor.Ann NY Acad Sci. 1969; 168: 105-110
- Protection of a complement-sensitive enzyme system by rheumatoid factor.J Immunol. 1964; 92: 139-142
- An inhibitor of the complement fixation reaction.Arthritis Rheum. 1962; 5: 127-129
Simόn JA, Navarro J, Villa A, Kraus A. Es el factor reumatoide protector de dano en pasientes con lupus eritematoso generalizato? Rev Mex Reum 2001;16:58 (Abstract).
- Systemic lupus erythematosus—adult onset.in: Maddison P.J. Isenberg D.A. Woo P. Glass D.N. Oxford textbook of rheumatology. 2nd edn. Oxford University press, Oxford1998: 1145-1180
- Disease activity in systemic lupus erythematosus: report of the Consensus Study Group of the European Workshop for Rheumatology Research. I. A descriptive analysis of 704 European lupus patients. European Consensus Study Group for Disease Activity in SLE.Clin Exp Rheumatol. 1992; 10: 527-539
- Systemic lupus erythematosus: delineation of subpopulations by clinical, serological, and T cell subset analysis.Am J Med Sci. 1985; 289: 139-147
- Rheumatoid factor and anti-citrullinated protein antibodies in rheumatoid arthritis: diagnostic value, associations with radiological progression rate, and extra-articular manifestations.Ann Rheum Dis. 2004; 63: 1587-1593
- Jaccoud's syndrome.Clin Rheumatol Dis. 1984; 1: 125-148
- Jaccoud's arthropathy in scleroderma.Clin Exp Rheumatol. 1984; 2: 337-340
- Jaccoud's arthropathy in adult dermatomyositis.Clin Exp Rheumatol. 1986; 4: 273-276
- Systemic lupus erythematosus with Jaccoud's arthropathy mimicking juvenile rheumatoid arthritis.Arthritis Rheum. 1987; 30: 1062-1064
- Hand deformities in a patient with chronic lung disease; Jaccoud's arthropathy.Clin Rheumatol. 1983; 2: 65-69
- Jaccoud's-type arthropathy: an association with sarcoidosis.J Rheumatol. 1991; 18: 915-917
- Jaccoud's arthritis and panvasculitis in the hypocomplementemic urticarial vasculitis syndrome.J Rheumatol. 1988; 15: 858-861
- Hypocomplementemic urticarial vasculitis syndrome, Jaccoud's syndrome, valvulopathy: a new syndromic combination.J Rheumatol. 1993; 20: 1236-1240
Article info
Publication history
Published online: April 02, 2008
Accepted:
January 20,
2008
Received in revised form:
December 21,
2007
Received:
June 2,
2007
Identification
Copyright
© 2008 European Federation of Internal Medicine. Published by Elsevier Inc. All rights reserved.
