Survival after cardiac arrest depends on early recognition and call for help, early
cardiopulmonary resuscitation, early defibrillation and advanced life support and
post-resuscitation care. This sequence of events is often referred to as the ‘chain
of survival’. Although advanced life support is an essential part of the ‘chain of
survival’, it has never been proven to improve outcome. On the other hand, early access
to emergency medical care, early bystander cardiopulmonary resuscitation (CPR) and
early defibrillation are clearly associated with better survival to hospital discharge
[
[1]
]. Furthermore, tailored post-resuscitation care seems of utmost importance: resuscitative
therapeutic hypothermia, for instance, improves survival and neurological outcome
[
2
,
3
]. Despite such advantages, however, outcome after out-of-hospital cardiac arrest remains
very poor. Even when only ventricular fibrillation (VF) is considered, survival rates
after hospital discharge range from 3 to 33% [
[4]
]. Reported survival rates to hospital discharge after in-hospital cardiac arrest varies
from 0–42%, the most common range being between 15 and 20% [
[5]
].Keywords
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References
- Advanced cardiac life support in out-of-hospital cardiac arrest.N Engl J Med. 2004; 351: 647-656
- Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest.N Engl Med. 2002; 346: 546-549
- Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia.N Engl J Med. 2002; 346: 557-563
- Long-term outcomes of out-of-hospital cardiac arrest after successful early defibrillation.N Engl J Med. 2003; 348: 2626-2633
- In-hospital cardiac arrest: incidence, prognosis and possible measures to improve survival.Intensive Care Med. 2007; 33: 237-245
- Empiric tenecteplase is associated with increased return of spontaneous circulation and short term survival in cardiac arrest patients unresponsive to standard interventions.Resuscitation. 2006; 69: 399-406
- Thrombolysis using plasminogen activator and heparin reduces cerebral no-reflow after resuscitation from cardiac arrest: an experimental study in the cat.Intensive Care Med. 1996; 22: 1214-1223
- Thrombolytic therapy after cardiac arrest and its effect on neurological outcome.Resuscitation. 2002; 52: 63-69
- Bolus injection of thrombolytic agents during cardiopulmonary resuscitation for massive pulmonary embolism.Resuscitation. 1994; 28: 45-54
- Case 17-2004: a 42-year-old woman with cardiac arrest several weeks after an ankle fracture.N Engl J Med. 2004; 250: 2281-2290
- Thrombolysis during cardiopulmonary resuscitation in fulminant pulmonary embolism: a review.Crit Care Med. 2001; 29: 2211-2219
- Out-of-hospital thrombolysis during cardiopulmonary resuscitation in patients with high likelihood of ST-elevation myocardial infarction.Resuscitation. 2008; 76: 180-184
- Out of hospital thrombolytic therapy during cardiopulmonary resuscitation in refractory cardiac arrest due to acute myocardial infarction.Eur J Emerg Med. 2001; 8: 241-243
- Efficacy of thrombolysis in patients with acute myocardial infarction requiring cardiopulmonary resuscitation.Intensive Care Med. 2001; 27: 1050-1057
- Efficacy and safety of thrombolytic therapy after initially unsuccessful cardiopulmonary resuscitation: a prospective clinical trial.Lancet. 2001; 357: 1583-1585
- Recombinant tissue plasminogen activator during cardiopulmonary resuscitation in 108 patients with out-of-hospital cardiac arrest.Resuscitation. 2001; 50: 71-76
- Tissue plasminogen activator in cardiac arrest with pulseless electrical activity.N Engl J Med. 2002; 246: 1522-1528
- A pilot randomised trial of thrombolysis in cardiac arrest (the TICA trial).Resuscitation. 2004; 61: 309-313
- International multicentre trial protocol to assess the efficacy and safety of tenecteplase during cardiopulmonary resuscitation in patients with out-of-hospital cardiac arrest: the Thrombolysis in Cardiac Arrest (TROICA) study.Eur J Clin Inves. 2005; 3: 315-323
- Safety of thrombolysis during cardiopulmonary resuscitation.Drug Safety. 2003; 26: 367-379
- Cause of death in unsuccessful prehospital resuscitation.J Inter Med. 1991; 229: 331-335
- Out-of-hospital cardiac arrests of non-cardiac origin. Epidemiology and outcome.European Heart J. 1997; 18: 1122-1128
- Aetiology of unsuccessful prehospital witnessed cardiac arrest of unclear origin.Eur J Emerg Med. 2006; 13: 144-147
- Part 4: advanced Life Support.Circulation. 2005; 112 (III-25-III54)
- European Resuscitation Council Guidelines for Resuscitation 2005. Section 4. Adult advanced life support.Resuscitation. 2005; 67: S39-S86
- Successful outcome of cardiopulmonary arrest with systemic thrombolysis.Eur J Int Med. 2008; 19: e38-e39
Article info
Publication history
Published online: April 30, 2008
Accepted:
March 11,
2008
Received:
March 9,
2008
Identification
Copyright
© 2008 European Federation of Internal Medicine. Published by Elsevier Inc. All rights reserved.