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Association of tuberculosis and deep venous thromboembolism in patients with autoimmune diseases

Published:April 22, 2015DOI:https://doi.org/10.1016/j.ejim.2015.04.011
      Tuberculosis (TB) can complicate the course of various autoimmune diseases, especially with prolonged use of immunosuppressive treatment [
      • Darras-Joly C.
      • Wechsler B.
      • Blétry O.
      • Du L.T.
      • Raguin G.
      • Godeau P.
      • et al.
      Tuberculosis and systemic diseases. Apropos of 16 cases.
      ,
      • Allali F.
      • Rkain H.
      • Faik A.
      • El Hassani S.
      • Hajjaj-Hassouni N.
      Prevalence and clinical characteristics of tuberculosis in rheumatoid arthritis patients.
      ,
      • Carmona L.
      • Hernández-García C.
      • Vadillo C.
      • Pato E.
      • Balsa A.
      • González-Alvaro I.
      • et al.
      Increased risk of tuberculosis in patients with rheumatoid arthritis.
      ,
      • Kim H.Y.
      • Im J.G.
      • Goo J.M.
      • Lee J.K.
      • Song J.W.
      • Kim S.K.
      Pulmonary tuberculosis in patients with systematic lupus erythematosus.
      ,
      • Diallo S.
      • Ndongo S.
      • Leye A.
      • Pouye A.
      • Ka M.M.
      • Diop T.M.
      Tuberculosis and systemic diseases: study of 8 Senegalese cases.
      ,
      • Yun J.E.
      • Lee S.W.
      • Kim T.H.
      • Jun J.B.
      • Jung S.
      • Bae S.C.
      • et al.
      The incidence and clinical characteristics of Mycobacterium tuberculosis infection among systemic lupus erythematosus and rheumatoid arthritis patients in Korea.
      ,
      • Feng P.H.
      • Tan T.H.
      Tuberculosis in patients with systemic lupus erythematosus.
      ,
      • Hernández-Cruz B.
      • Sifuentes-Osornio J.
      • Ponce-de-León Rosales S.
      • Ponce-de-León Garduño A.
      • Díaz-Jouanen E.
      Mycobacterium tuberculosis infection in patients with systemic rheumatic diseases. A case-series.
      ,
      • Kim H.A.
      • Yoo C.D.
      • Baek H.J.
      • Lee E.B.
      • Ahn C.
      • Han J.S.
      • et al.
      Mycobacterium tuberculosis infection in a corticosteroid-treated rheumatic disease patient population.
      ]. Limited data are currently available regarding risk factors for, and clinical presentation of, TB in patients with autoimmune diseases. We performed an observational study of all cases of TB diagnosed during years 1992–2012 within a cohort of patients followed for autoimmune diseases in a 1800-bed university hospital, which serves as a referral center for autoimmune diseases in Western France (population catchment area, one million inhabitants). Inclusion criteria were those requested within the national TB mandatory notification form: TB diagnosed either by culture of any specimen positive for Mycobacterium tuberculosis complex, or by the combination of i) clinical or radiological signs suggestive of TB, and ii) initiation of anti-TB treatment. Data were collected from medical charts on a standardized questionnaire. Extrapulmonary TB was defined as TB with any location outside of the lung parenchyma, with or without pulmonary involvement. Institutional review board approval was waived because the study was observational and data were collected anonymously.

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