Tuberculosis (TB) can complicate the course of various autoimmune diseases, especially
with prolonged use of immunosuppressive treatment [
1
,
2
,
3
,
4
,
5
,
6
,
7
,
8
,
9
]. Limited data are currently available regarding risk factors for, and clinical presentation
of, TB in patients with autoimmune diseases. We performed an observational study of
all cases of TB diagnosed during years 1992–2012 within a cohort of patients followed
for autoimmune diseases in a 1800-bed university hospital, which serves as a referral
center for autoimmune diseases in Western France (population catchment area, one million
inhabitants). Inclusion criteria were those requested within the national TB mandatory
notification form: TB diagnosed either by culture of any specimen positive for Mycobacterium tuberculosis complex, or by the combination of i) clinical or radiological signs suggestive of
TB, and ii) initiation of anti-TB treatment. Data were collected from medical charts
on a standardized questionnaire. Extrapulmonary TB was defined as TB with any location
outside of the lung parenchyma, with or without pulmonary involvement. Institutional
review board approval was waived because the study was observational and data were
collected anonymously.Keywords
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Article info
Publication history
Published online: April 22, 2015
Accepted:
April 9,
2015
Received:
April 3,
2015
Identification
Copyright
© 2015 European Federation of Internal Medicine. Published by Elsevier Inc. All rights reserved.
