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Gout is associated with organic and psychogenic erectile dysfunction

  • Chao-Yu Hsu
    Affiliations
    Department of Medical Education and Research, Puli Christian Hospital, Puli, Taiwan

    Department of Optometry, Central Taiwan University of Science and Technology, Taichung, Taiwan

    Center for General Education, National Chi Nan University, Puli, Taiwan

    Center for General Education, National Taichung University of Science and Technology, Taichung, Taiwan

    The General Education Center, Chaoyang University of Technology, Taichung, Taiwan

    Department of General Education, National Chin-Yi University of Technology, Taichung, Taiwan
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  • Cheng-Li Lin
    Affiliations
    Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan

    College of Medicine, China Medical University, Taichung, Taiwan
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  • Chia-Hung Kao
    Correspondence
    Corresponding author at: Graduate Institute of Clinical Medical Science and School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan. No. 2, Yuh-Der Road, Taichung 404, Taiwan. Tel.: +886 4 22052121x7412; fax: +886 4 22336174.
    Affiliations
    Graduate Institute of Clinical Medical Science and School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan

    Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan
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      Highlights

      • Men with gout have an increased risk (1.21 times) of ED.
      • The risk of developing ED was greater for patients with comorbidities.
      • Gout is associated not only with prevalently organic but also psychogenic ED.

      Abstract

      Background

      Gout is a deposition disease with an inflammatory response that can increase the risk of cardiovascular disease. Gout is stressful for affected individuals, and can cause erectile dysfunction (ED). The objective of this study was to identify the association between gout and psychogenic ED (PED) and organic ED (OED).

      Method

      We analyzed 35,265 patients from the National Health Insurance Research Database who had been diagnosed with gout between 2000 and 2011. A total of 70,529 matched controls were included in the study as a comparison. Patients with a history of PED and OED occurring before the index date, aged less than 20 years, or with incomplete demographic information were excluded. Control patients were selected from the population of people without a history of gout, PED, or OED. The following risk factors for PED and OED were included as covariates in the multivariable models: age, comorbidities of coronary artery disease (CAD), peripheral arterial disease, chronic kidney disease (CKD), hypertension, diabetes, hyperlipidemia, depression and anxiety.

      Result

      Men with gout were more likely to have an increased risk (1.21 times) of ED than were those without gout. Patients with gout were 1.52 times more likely to develop OED and 1.18 times more likely to develop PED than patients in the control group. The risk of developing ED was greater for patients with comorbidities of CKD, diabetes, hyperlipidemia, depression and anxiety.

      Conclusion

      Gout is associated with organic and psychogenic ED. Clinical physicians should consider this association when treating patients with gout.

      Keywords

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