Highlights
- •Cholecystectomy was associated with a reduced risk of pancreatitis.
- •Pancreatitis risk was decreased in patients younger than 50 and older than 65 years.
- •Both men and women exhibited reduced risks of pancreatitis after cholecystectomy.
Abstract
Background & aim
Patients with biliary pancreatitis are suggested to undergo cholecystectomy to prevent
the recurrence of pancreatitis. However, it remains controversial whether cholecystectomy
is associated with reduced risks of pancreatitis and diabetes in patients with cholelithiasis
and no history of pancreatitis.
Methods
From Taiwan's National Health Insurance Research Database, we identified the following
cohorts and analyzed the long-term risks of pancreatitis and diabetes in each cohort:
1) cholecystectomy cohort: cholelithiasis patients who had no history of pancreatitis
and diabetes and underwent cholecystectomy; and 2) comparison cohort: cholelithiasis
patients who had no history of pancreatitis and diabetes and did not undergo cholecystectomy.
Results
The cholecystectomy group and the comparison group had similar distributions of age,
sex, and comorbidities, except for hyperlipidemia. The proportion of patients in the
cholecystectomy group who underwent endoscopic cholangiographic procedures was higher
than that in the comparison group. Cholecystectomy was associated with a reduced risk
of pancreatitis (adjusted hazard ratio [HR], 0.49; 95% confidence interval [CI], 0.36–0.68).
Age-specific analyses showed that pancreatitis risk was decreased in patients younger
than 50 and older than 65 years. Both men and women exhibited reduced risks of pancreatitis after cholecystectomy.
However, cholecystectomy was not associated with changes in the risk for diabetes.
Conclusion
Cholecystectomy for cholelithiasis is associated with a reduced risk of pancreatitis,
but not of diabetes, in patients without previous history of pancreatitis and diabetes.
Abbreviations:
HR (hazard ratio), CI (confidence interval), NHIRD (National Health Insurance Research Database), LC (laparoscopic cholecystectomy), NHI (National Health Insurance), LHID2000 (the Longitudinal Health Insurance Database 2000), ICD-9-CM (International Classification of Diseases, Ninth Revision, Clinical Modification)Keywords
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Article info
Publication history
Published online: July 02, 2015
Accepted:
June 22,
2015
Received in revised form:
June 21,
2015
Received:
May 21,
2015
Identification
Copyright
© 2015 European Federation of Internal Medicine. Published by Elsevier Inc. All rights reserved.
