Highlights
- •The statin cohort had a significant lower risk of PUD for all age group.
- •The concomitant use of aspirin and/or NSAIDs had higher incidence of PUD.
- •High-dose groups (≧575 DDD) exhibited significantly decreased risk.
Abstract
Background
This study was to determine the association between the use of statins and the occurrence
of peptic ulcer diseases (PUD).
Methods
Using the National Health Insurance Research Database to conduct a population-based
cohort study. We identified 48,562 patients who were newly diagnosed with hyperlipidemia
during the period of 1998 to 2011 and who were divided into two groups based on their
use of statins. The non-statin cohort (without statin treatment, 24,139 patients)
were 1:1 frequency matched with sex, age, year of diagnosis of hyperlipidemia and
index-year to the statin cohort (24,423 patients). The relative risk of patients with
and without statins treatment on the occurrence of PUD and concomitant use of nonsteroidal
anti-inflammatory drugs (NSAIDs) and aspirin were analyzed using the univariable and
multivariable Cox proportional hazards regression model.
Results
The incidence of PUD increased with age in both cohorts and female had a higher occurrence
rate than male in both cohorts. Compared with the non-statin cohort, the statin cohort
was associated with a significant lower risk of PUD for all age group. The concomitant
use of aspirin and/or NSAIDs had higher incidence of PUD than those without in both
cohorts. Analyzing the cumulative defined daily dose (DDD) of statins indicated that
high-dose groups (≧575 DDD) exhibited significantly decreased risk compared with non-statin users.
Conclusion
The results of the present study indicated that statins might be associated with the
protection of peptic ulcer in a dose-respondent manner.
Keywords
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Article info
Publication history
Published online: July 28, 2015
Accepted:
July 14,
2015
Received in revised form:
July 13,
2015
Received:
March 3,
2015
Identification
Copyright
© 2015 European Federation of Internal Medicine. Published by Elsevier Inc. All rights reserved.
