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Letter to the Editor| Volume 26, ISSUE 10, e63-e64, December 2015

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Hypervitaminemia B12 in elderly patients: Frequency and nature of the associated or linked conditions. Preliminary results of a study in 190 patients

Published:September 22, 2015DOI:https://doi.org/10.1016/j.ejim.2015.09.007
Hypervitaminemia B12 in elderly patients: Frequency and nature of the associated or linked conditions. Preliminary results of a study in 190 patients
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      Hypervitaminemia B12 is a common laboratory abnormality, frequently unknown. Hypervitaminemia B12 has been associated or linked with a range of conditions, the majority of which are serious, with a systematic inquiry being decisive for prognosis [
      • Andrès E.
      • Serraj K.
      • Zhu J.
      • Vermorken A.J.M.
      The pathophysiology of elevated vitamin B12 in clinical practice.
      QJM. 2013; 106: 505-515
      ,
      • Chiche L.
      • Jean R.
      • Romain F.
      • Roux F.
      • Thomas G.
      • Canavese S.
      • et al.
      Implications cliniques de la découverte d'une hypervitaminémie B12 en médecine interne.
      Rev Med Interne. 2008; 29: 187-194
      ,
      • Arendt J.F.B.
      • Nexo E.
      Cobalamin related parameters and disease patterns in patients with increased serum cobalamin levels.
      PLoS One. 2012; 7e45979
      ]. But in practice, physicians often do not know what to do. There are currently a few studies which fulfilled the criteria of evidence based-medicine exploring this theme. This letter reports preliminary results of such a study in a well-documented population of elderly patients. The objective of the present study is to determine the frequency of hypervitaminemia B12 and the nature of the associated or linked conditions.

      Keywords

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      References

        • Andrès E.
        • Serraj K.
        • Zhu J.
        • Vermorken A.J.M.
        The pathophysiology of elevated vitamin B12 in clinical practice.
        QJM. 2013; 106: 505-515
        View in Article
        • Chiche L.
        • Jean R.
        • Romain F.
        • Roux F.
        • Thomas G.
        • Canavese S.
        • et al.
        Implications cliniques de la découverte d'une hypervitaminémie B12 en médecine interne.
        Rev Med Interne. 2008; 29: 187-194
        View in Article
        • Arendt J.F.B.
        • Nexo E.
        Cobalamin related parameters and disease patterns in patients with increased serum cobalamin levels.
        PLoS One. 2012; 7e45979
        View in Article
        • Chiche L.
        • Mancini J.
        • Arlet J.-B.
        Hypervitaminémies B12 en médecine interne: résultats de l'étude BDOSE.
        Rev Med Interne. 2009; 30: S377
        View in Article
        • Serraj K.
        • Mecili M.
        • Housni I.
        • Andrès E.
        Hypervitaminemia B12 (high level of cobalamin): physiopathology, role and interest in clinical practice.
        Presse Med. 2011; 40: 1120-1127
        View in Article

      Article info

      Publication history

      Published online: September 22, 2015
      Accepted: September 9, 2015
      Received in revised form: September 8, 2015
      Received: September 2, 2015

      Identification

      DOI: https://doi.org/10.1016/j.ejim.2015.09.007

      Copyright

      © 2015 European Federation of Internal Medicine. Published by Elsevier Inc. All rights reserved.

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