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Hypervitaminemia B12 in elderly patients: Frequency and nature of the associated or linked conditions. Preliminary results of a study in 190 patients

Published:September 22, 2015DOI:https://doi.org/10.1016/j.ejim.2015.09.007
      Hypervitaminemia B12 is a common laboratory abnormality, frequently unknown. Hypervitaminemia B12 has been associated or linked with a range of conditions, the majority of which are serious, with a systematic inquiry being decisive for prognosis [
      • Andrès E.
      • Serraj K.
      • Zhu J.
      • Vermorken A.J.M.
      The pathophysiology of elevated vitamin B12 in clinical practice.
      ,
      • Chiche L.
      • Jean R.
      • Romain F.
      • Roux F.
      • Thomas G.
      • Canavese S.
      • et al.
      Implications cliniques de la découverte d'une hypervitaminémie B12 en médecine interne.
      ,
      • Arendt J.F.B.
      • Nexo E.
      Cobalamin related parameters and disease patterns in patients with increased serum cobalamin levels.
      ]. But in practice, physicians often do not know what to do. There are currently a few studies which fulfilled the criteria of evidence based-medicine exploring this theme. This letter reports preliminary results of such a study in a well-documented population of elderly patients. The objective of the present study is to determine the frequency of hypervitaminemia B12 and the nature of the associated or linked conditions.

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      References

        • Andrès E.
        • Serraj K.
        • Zhu J.
        • Vermorken A.J.M.
        The pathophysiology of elevated vitamin B12 in clinical practice.
        QJM. 2013; 106: 505-515
        • Chiche L.
        • Jean R.
        • Romain F.
        • Roux F.
        • Thomas G.
        • Canavese S.
        • et al.
        Implications cliniques de la découverte d'une hypervitaminémie B12 en médecine interne.
        Rev Med Interne. 2008; 29: 187-194
        • Arendt J.F.B.
        • Nexo E.
        Cobalamin related parameters and disease patterns in patients with increased serum cobalamin levels.
        PLoS One. 2012; 7e45979
        • Chiche L.
        • Mancini J.
        • Arlet J.-B.
        Hypervitaminémies B12 en médecine interne: résultats de l'étude BDOSE.
        Rev Med Interne. 2009; 30: S377
        • Serraj K.
        • Mecili M.
        • Housni I.
        • Andrès E.
        Hypervitaminemia B12 (high level of cobalamin): physiopathology, role and interest in clinical practice.
        Presse Med. 2011; 40: 1120-1127