- •CD was more likely in hypothyroid patients requiring escalated levothyroxine.
- •CD prevalence increased directly with daily levothyroxine dose (range 1.8%–12.5%).
- •Patients requiring ≥125 mcg/day of levothyroxine had a CD prevalence of 5.6%.
- •A threshold levothyroxine dose of ≥125 mcg/day should stimulate CD testing.
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☆☆Financial support: The University of Vermont Medical Center Department of Internal Medicine .