Advertisement

Cardiospecific troponin immunoassays: How low is it worth to go?

Published:December 02, 2015DOI:https://doi.org/10.1016/j.ejim.2015.11.015
      We read with interest the recent article of Bouzas-Mosquera et al., who investigated the impact effect of cardiac troponin I (cTnI) values on the frequency of myocardial ischemia and subsequent coronary events in patients with acute chest pain and biomarker concentration within the normal range [
      • Bouzas-Mosquera A.
      • Peteiro J.
      • Broullón F.J.
      • Constanso I.P.
      • Rodríguez-Garrido J.L.
      • Martínez D.
      • et al.
      Troponin levels within the normal range and probability of inducible myocardial ischemia and coronary events in patients with acute chest pain.
      ]. The evidence emerged from this well structured study underpins a number of critical issues.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to European Journal of Internal Medicine
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Bouzas-Mosquera A.
        • Peteiro J.
        • Broullón F.J.
        • Constanso I.P.
        • Rodríguez-Garrido J.L.
        • Martínez D.
        • et al.
        Troponin levels within the normal range and probability of inducible myocardial ischemia and coronary events in patients with acute chest pain.
        Eur J Intern Med. 2016; 28: 59-64
        • Sze J.
        • Mooney J.
        • Barzi F.
        • Hillis G.S.
        • Chow C.K.
        Cardiac troponin and its relationship to cardiovascular outcomes in community populations—a systematic review and meta-analysis.
        Heart Lung Circ. Oct 9 2015; ([Epub ahead of print])https://doi.org/10.1016/j.hlc.2015.09.001
        • Shah A.S.
        • Anand A.
        • Sandoval Y.
        • Lee K.K.
        • Smith S.W.
        • Adamson P.D.
        • et al.
        High-sensitivity cardiac troponin I at presentation in patients with suspected acute coronary syndrome: a cohort study.
        Lancet. Oct 7 2015; ([Epub ahead of print])https://doi.org/10.1016/S0140-6736(15)00391-8
        • Lippi G.
        • Cervellin G.
        The latest generation of troponin immunoassays: the “cholesterol” of the third millennium?.
        J Am Coll Cardiol. 2014; 63: 2883-2884
        • Lippi G.
        Biomarkers of myocardial ischemia in the emergency room: cardiospecific troponin and beyond.
        Eur J Intern Med. 2013; 24: 97-99
        • Lippi G.
        • Schena F.
        • Dipalo M.
        • Montagnana M.
        • Salvagno G.L.
        • Aloe R.
        • Guidi G.C.
        Troponin I measured with a high sensitivity immunoassay is significantly increased after a half marathon run.
        Scand J Clin Lab Invest. 2012; 72: 467-470