Highlights
- •Increased cumulative incidence of ischemic stroke in the CO-poisoning cohort.
- •The CO-poisoning relative risk was greatest in the youngest group (20–34 years).
- •The relative risk of ischemic stroke was approximately 2.60-fold.
Abstract
Background
The long-term consequence of cardiovascular health has not been evaluated for patients
with carbon monoxide (CO) poisoning. This study evaluated the risk of ischemic stroke
using population-based data.
Methods
We identified 8705 inpatients with CO intoxication diagnosed from 2000 to 2011 from
the Taiwan National Health Insurance Research Database. The control cohort consisted
of 34,820 persons randomly identified from patients without exposure frequency matched
by age, sex, and the year of hospitalization. Incidence and hazard ratio (HR) of ischemic
stroke were evaluated by sociodemographic factors and comorbidities by the end of
2011.
Results
The incidence of ischemic stroke revealed a significant increase in the CO-poisoning
cohort over the follow-up period (p < 0.001). The overall incidence of ischemic stroke was near 2.5-fold greater in the
CO-poisoned cohort than in controls (5.49 versus 2.02 per 1000 person-years), with
an adjusted HR of 2.60 (95% confidence interval (CI) = 2.15–3.15). The adjusted HR for those without comorbidities was slightly higher (2.76,
95% CI = 2.13–3.58). The age-specific CO-poisoning to non-CO-poisoning relative risk was greatest
in the youngest group (20–34 years) (adjusted HR = 6.45; 95% CI = 3.30–12.6).
Conclusion
CO poisoning is associated with a long-term risk of increased incident ischemic stroke.
Further study on the mechanism of ischemic stroke for CO poisoning affects is needed.
Keywords
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Article info
Publication history
Published online: December 16, 2015
Accepted:
November 29,
2015
Received in revised form:
October 2,
2015
Received:
June 12,
2015
Identification
Copyright
© 2015 European Federation of Internal Medicine. Published by Elsevier Inc. All rights reserved.
