Highlights
- •The renal effects of statins remain unclear.
- •This population-based case–control study showed that statin use might be associated with increased ESRD risks.
Abstract
Background
Although experimental models have shown that statins could alleviate glomerular damage
and decrease urinary protein excretion, the renal effects of statins remain unclear.
A case–control study was conducted using data from Taiwan's National Health Insurance
system.
Methods
An end-stage renal disease (ESRD) group comprising 11,486 patients was established.
Each patient was frequency-matched by age, sex, and comorbidities with one person
without ESRD from the general population. Logistic regression analysis was performed
to estimate the influence of statin use on ESRD risk.
Results
The overall adjusted odds ratios (ORs) of ESRD among patients who received statins
was 1.59 (95% confidence interval = 1.50–1.68). The raised ESRD risk of statin remained consolidated regardless of statin
type (P < .001), except lovastatin. Further, while stratified by cumulative define daily dose,
the risk of ESRD increased with accumulative dosage of statins (P for trend < .001).
Conclusion
This population-based case–control study showed that statin use might be associated
with increased ESRD risks. Large-scale randomized clinical trial encompassing statins
of different kinds and populations of different comorbidities would be helpful to
clarify the potential ESRD risks of statin users
Keywords
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Article info
Publication history
Published online: February 24, 2016
Accepted:
February 4,
2016
Received in revised form:
January 23,
2016
Received:
November 19,
2015
Identification
Copyright
© 2016 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.
