Advertisement

Neuropsychological performance of young familial hypercholesterolemia patients

  • Mar Ariza
    Affiliations
    Brain, Cognition and Behaviour: Clinical Research, Consorci Sanitari de Terrassa, Terrassa, Spain

    Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain
    Search for articles by this author
  • Natalia Cuenca
    Affiliations
    Brain, Cognition and Behaviour: Clinical Research, Consorci Sanitari de Terrassa, Terrassa, Spain

    Neuropsychology Unit, Hospital de Terrassa, Consorci Sanitari de Terrassa, Terrassa, Spain
    Search for articles by this author
  • Marta Mauri
    Affiliations
    Brain, Cognition and Behaviour: Clinical Research, Consorci Sanitari de Terrassa, Terrassa, Spain

    Department of Internal Medicine, Hospital de Terrassa, Consorci Sanitari de Terrassa, Terrassa, Spain
    Search for articles by this author
  • M. Angels Jurado
    Affiliations
    Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain

    Institute for Brain, Cognition and Behaviour (IR3C), Barcelona, Spain

    Grup de Recerca Consolidat en Neuropsicologia (2014SGR98), Spain
    Search for articles by this author
  • Maite Garolera
    Correspondence
    Corresponding author at: Neuropsychology Unit, Hospital de Terrassa, Consorci Sanitari de Terrassa, Carretera Torrebonica s/n, 08227 Terrassa, Spain.
    Affiliations
    Brain, Cognition and Behaviour: Clinical Research, Consorci Sanitari de Terrassa, Terrassa, Spain

    Neuropsychology Unit, Hospital de Terrassa, Consorci Sanitari de Terrassa, Terrassa, Spain

    Grup de Recerca Consolidat en Neuropsicologia (2014SGR98), Spain
    Search for articles by this author
      Familial hypercholesterolemia (FH) is the most common disorder of lipid metabolism and can be caused by defects in different genes that code for proteins involved in hepatic clearance of low-density lipoprotein-cholesterol (LDL-C). FH subjects may develop premature atherosclerotic cardiovascular disease and they have a much higher risk of dying from a coronary event than do the general population [ ]. In addition, FH patients appear to have an increased risk of cognitive impairment in old age [
      • Kivipelto M.
      • Helkala E.L.
      • Laakso M.P.
      • Hänninen T.
      • Hallikainen M.
      • Alhainen K.
      • et al.
      Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study.
      ,
      • Zambón D.
      • Quintana M.
      • Mata P.
      • Alonso R.
      • Benavent J.
      • Cruz-Sánchez F.
      • et al.
      Higher incidence of mild cognitive impairment in familial hypercholesterolemia.
      ]. Patients with FH, who are exposed to higher cholesterol levels from early life, may be regarded as a potential high-risk group for cognitive decline [
      • Zambón D.
      • Quintana M.
      • Mata P.
      • Alonso R.
      • Benavent J.
      • Cruz-Sánchez F.
      • et al.
      Higher incidence of mild cognitive impairment in familial hypercholesterolemia.
      ]. However, no study to date has examined whether neuropsychological deficits are present in young subjects with FH. We aimed to determine whether young patients afflicted with FH exhibit cognitive abnormalities.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to European Journal of Internal Medicine
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

      1. Atherosclerosis. 1999; 142: 105-112
        • Kivipelto M.
        • Helkala E.L.
        • Laakso M.P.
        • Hänninen T.
        • Hallikainen M.
        • Alhainen K.
        • et al.
        Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study.
        BMJ. 2001; 322: 1447-1451
        • Zambón D.
        • Quintana M.
        • Mata P.
        • Alonso R.
        • Benavent J.
        • Cruz-Sánchez F.
        • et al.
        Higher incidence of mild cognitive impairment in familial hypercholesterolemia.
        Am J Med. 2010; 123: 267-274https://doi.org/10.1016/j.amjmed.2009.08.015
        • Ariza M.
        • Garolera M.
        • Jurado M.A.
        • Garcia-Garcia I.
        • Hernan I.
        • Sánchez-Garre C.
        • et al.
        Dopamine genes (DRD2/ANKK1-TaqA1 and DRD4-7R) and executive function: their interaction with obesity.
        PLoS One. 2012; 7e41482https://doi.org/10.1371/journal.pone.0041482
        • Cohen J.
        Statistical power analysis for the behavioural sciences.
        2nd ed. Academic Press, New York1988
        • Münzel T.
        • Gori T.
        • Bruno R.M.
        • Taddei S.
        Is oxidative stress a therapeutic target in cardiovascular disease?.
        Eur Heart J. 2010; 31: 2741-2748https://doi.org/10.1093/eurheartj/ehq396
        • Steinberg D.
        Atherogenesis in perspective: hypercholesterolemia and inflammation as partners in crime.
        Nat Med. 2002; 8: 1211-1217
        • Evola M.
        • Hall A.
        • Wall T.
        • Young A.
        • Grammas P.
        Oxidative stress impairs learning and memory in apoE knockout mice.
        Pharmacol Biochem Behav. 2010; 96: 181-186https://doi.org/10.1016/j.pbb.2010.05.003
        • Moreira E.L.G.
        • de Oliveira J.
        • Nunes J.C.
        • Santos D.B.
        • Nunes F.C.
        • Vieira D.S.C.
        • et al.
        Age-related cognitive decline in hypercholesterolemic LDL receptor knockout mice (LDLr−/−): evidence of antioxidant imbalance and increased acetylcholinesterase activity in the prefrontal cortex.
        J Alzheimers Dis. 2012; 32: 495-511https://doi.org/10.3233/JAD-2012-120541
        • Ramírez C.
        • Sierra S.
        • Tercero I.
        • Vázquez J.A.
        • Pineda A.
        • Manrique T.
        • et al.
        ApoB100/LDLR−/− hypercholesterolaemic mice as a model for mild cognitive impairment and neuronal damage.
        PLoS One. 2011; 6e22712https://doi.org/10.1371/journal.pone.0022712