Familial hypercholesterolemia (FH) is the most common disorder of lipid metabolism
and can be caused by defects in different genes that code for proteins involved in
hepatic clearance of low-density lipoprotein-cholesterol (LDL-C). FH subjects may
develop premature atherosclerotic cardiovascular disease and they have a much higher
risk of dying from a coronary event than do the general population [
[1]
]. In addition, FH patients appear to have an increased risk of cognitive impairment
in old age [
2
,
3
]. Patients with FH, who are exposed to higher cholesterol levels from early life,
may be regarded as a potential high-risk group for cognitive decline [
[3]
]. However, no study to date has examined whether neuropsychological deficits are present
in young subjects with FH. We aimed to determine whether young patients afflicted
with FH exhibit cognitive abnormalities.Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to European Journal of Internal MedicineAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Atherosclerosis. 1999; 142: 105-112
- Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study.BMJ. 2001; 322: 1447-1451
- Higher incidence of mild cognitive impairment in familial hypercholesterolemia.Am J Med. 2010; 123: 267-274https://doi.org/10.1016/j.amjmed.2009.08.015
- Dopamine genes (DRD2/ANKK1-TaqA1 and DRD4-7R) and executive function: their interaction with obesity.PLoS One. 2012; 7e41482https://doi.org/10.1371/journal.pone.0041482
- Statistical power analysis for the behavioural sciences.2nd ed. Academic Press, New York1988
- Is oxidative stress a therapeutic target in cardiovascular disease?.Eur Heart J. 2010; 31: 2741-2748https://doi.org/10.1093/eurheartj/ehq396
- Atherogenesis in perspective: hypercholesterolemia and inflammation as partners in crime.Nat Med. 2002; 8: 1211-1217
- Oxidative stress impairs learning and memory in apoE knockout mice.Pharmacol Biochem Behav. 2010; 96: 181-186https://doi.org/10.1016/j.pbb.2010.05.003
- Age-related cognitive decline in hypercholesterolemic LDL receptor knockout mice (LDLr−/−): evidence of antioxidant imbalance and increased acetylcholinesterase activity in the prefrontal cortex.J Alzheimers Dis. 2012; 32: 495-511https://doi.org/10.3233/JAD-2012-120541
- ApoB100/LDLR−/− hypercholesterolaemic mice as a model for mild cognitive impairment and neuronal damage.PLoS One. 2011; 6e22712https://doi.org/10.1371/journal.pone.0022712
Article info
Publication history
Published online: June 02, 2016
Accepted:
May 11,
2016
Received:
May 6,
2016
Identification
Copyright
© 2016 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.
