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Rapid hypoglycemia onset associated with antimicrobial use in patients with diabetes: A nationwide population-based case-crossover study

  • Yung-Chih Wang
    Affiliations
    Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, No. 325, Sec. 2, Chenggong Rd., Neihu District, Taipei City, Taiwan
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  • Author Footnotes
    1 Yung-Tai Chen and Shu-Chen Kuo contributed equally.
    Yung-Tai Chen
    Correspondence
    Corresponding author. Tel.: +886 2 2388 9595.
    Footnotes
    1 Yung-Tai Chen and Shu-Chen Kuo contributed equally.
    Affiliations
    Department of Nephrology, Taipei City Hospital, Heping Fuyou Branch, No. 145, Zhengzhou Rd., Datong Dist., Taipei City 10341, Taiwan
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  • Author Footnotes
    1 Yung-Tai Chen and Shu-Chen Kuo contributed equally.
    Shu-Chen Kuo
    Correspondence
    Corresponding author. Tel.: +886 37 246 166; fax: +886 37 586457.
    Footnotes
    1 Yung-Tai Chen and Shu-Chen Kuo contributed equally.
    Affiliations
    National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli County 35053, Taiwan
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  • Te-Li Chen
    Affiliations
    Graduate Institute of Life Science, National Defense Medical Center, No. 161, Sec. 6, Minquan E. Rd., Neihu Dist., Taipei City, Taiwan
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  • Feng-Yee Chang
    Affiliations
    Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, No. 325, Sec. 2, Chenggong Rd., Neihu District, Taipei City, Taiwan
    Search for articles by this author
  • Author Footnotes
    1 Yung-Tai Chen and Shu-Chen Kuo contributed equally.

      Highlights

      • The risk of hypoglycemia within a very short time in patients co-prescribed antimicrobials and sulfonylureas were analyzed.
      • An immediate effect of oral clarithromycin, levofloxacin, and sulfamethoxazole–trimethoprim on hypoglycemia in patients using sulfonylureas was found.
      • Clinicians should be aware of the immediate hypoglycemia risk after antimicrobials prescription.

      Keywords

      Abbreviations:

      OR (odds ratio), CI (confidence interval)
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