Highlights
- •The risk of hypoglycemia within a very short time in patients co-prescribed antimicrobials and sulfonylureas were analyzed.
- •An immediate effect of oral clarithromycin, levofloxacin, and sulfamethoxazole–trimethoprim on hypoglycemia in patients using sulfonylureas was found.
- •Clinicians should be aware of the immediate hypoglycemia risk after antimicrobials prescription.
Keywords
Abbreviations:
OR (odds ratio), CI (confidence interval)To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to European Journal of Internal MedicineAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Hypoglycemia and diabetes: a report of a workgroup of the American Diabetes Association and the Endocrine Society.Diabetes Care. 2013; 36: 1384-1395https://doi.org/10.2337/dc12-2480
- Hypoglycemia after antimicrobial drug prescription for older patients using sulfonylureas.JAMA Intern Med. 2014; 174: 1605-1612https://doi.org/10.1001/jamainternmed.2014.3293
- Risk of severe dysglycemia among diabetic patients receiving levofloxacin, ciprofloxacin, or moxifloxacin in Taiwan.Clin Infect Dis. 2013; 57: 971-980https://doi.org/10.1093/cid/cit439
- Anti-infectives and the risk of severe hypoglycemia in users of glipizide or glyburide.Clin Pharmacol Ther. 2010; 88: 214-222https://doi.org/10.1038/clpt.2010.74
- Pharmacokinetics and pharmacodynamics of antibacterial agents.Infect Dis Clin North Am. 2009; 23: 791-815https://doi.org/10.1016/j.idc.2009.06.008
- Severe hypoglycemia from clarithromycin-sulfonylurea drug interaction.Diabetes Care. 2002; 25: 1659-1661https://doi.org/10.2337/diacare.25.9.1659-a
- Severe and protracted hypoglycaemia associated with co-trimoxazole use.Lancet Infect Dis. 2006; 6: 178-182https://doi.org/10.1016/S1473-3099(06)70414-5
- The case-crossover design: a method for studying transient effects on the risk of acute events.Am J Epidemiol. 1991; 133: 144-153
- Risk of hospitalization and healthcare cost associated with diabetes complication severity index in Taiwan's National Health Insurance Research Database.J Diabetes Complications. 2014; 28: 612-616https://doi.org/10.1016/j.jdiacomp.2014.05.011
- Combating antimicrobial resistance: antimicrobial stewardship program in Taiwan.J Microbiol Immunol Infect. 2012; 45: 79-89https://doi.org/10.1016/j.jmii.2012.03.007
Article info
Publication history
Published online: May 24, 2016
Accepted:
May 11,
2016
Received in revised form:
May 3,
2016
Received:
April 30,
2016
Identification
Copyright
© 2016 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.
