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Risk of osteonecrosis in patients with systemic lupus erythematosus: A nationwide population-based study

      The occurrence of osteonecrosis (ON) in patients with systemic lupus erythematosus (SLE) was first quantified by Dubois et al. [
      • Dubois E.L.
      • Cozen L.
      Avascular (aseptic) bone necrosis associated with systemic lupus erythematosus.
      ] in 1960, in their report describing ON in 11 out of 400 SLE patients (2.8%). Newer studies, with access to information on magnetic resonance imagining screening of the lower limbs, have identified ON lesions in up to 37% of SLE patients [
      • Shigemura T.
      • Nakamura J.
      • Kishida S.
      • et al.
      Incidence of osteonecrosis associated with corticosteroid therapy among different underlying diseases: prospective MRI study.
      ] and in 44% of the hip and knee joints of SLE patients undergoing corticosteroid treatment [
      • Nakamura J.
      • Harada Y.
      • Oinuma K.
      • et al.
      Spontaneous repair of asymptomatic osteonecrosis associated with corticosteroid therapy in systemic lupus erythematosus: 10-year minimum follow-up with MRI.
      ]. Moreover, in patients with ON taking corticosteroids, SLE appears to be the most common underlying autoimmune disease [
      • Shigemura T.
      • Nakamura J.
      • Kishida S.
      • et al.
      Incidence of osteonecrosis associated with corticosteroid therapy among different underlying diseases: prospective MRI study.
      ,
      • Wang X.S.
      • Zhuang Q.Y.
      • Weng X.S.
      • et al.
      Etiological and clinical analysis of osteonecrosis of the femoral head in Chinese patients.
      ].

      Keywords

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