The occurrence of osteonecrosis (ON) in patients with systemic lupus erythematosus
(SLE) was first quantified by Dubois et al. [
[1]
] in 1960, in their report describing ON in 11 out of 400 SLE patients (2.8%). Newer
studies, with access to information on magnetic resonance imagining screening of the
lower limbs, have identified ON lesions in up to 37% of SLE patients [
[2]
] and in 44% of the hip and knee joints of SLE patients undergoing corticosteroid treatment
[
[3]
]. Moreover, in patients with ON taking corticosteroids, SLE appears to be the most
common underlying autoimmune disease [
2
,
4
].Keywords
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References
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- LUMINA study group. Systemic lupus erythematosus in a multiethnic US cohort (LUMINA): XXIV. Cytotoxic treatment is an additional risk factor for the development of symptomatic osteonecrosis in lupus patients: results of a nested matched case–control study.Ann Rheum Dis. 2006; 65: 785-790
- Osteonecrosis of the hip in Korean patients with systemic lupus erythematosus: risk factors and clinical outcome.Lupus. 2014; 23: 39-45
- Disease activity as a major risk factor for osteonecrosis in early systemic lupus erythematosus.Lupus. 2007; 16: 239-244
- Development of new osteonecrosis in systemic lupus erythematosus patients in association with long-term corticosteroid therapy after disease recurrence.Clin Exp Rheumatol. 2010; 28: 13-18
Article info
Publication history
Published online: July 14, 2016
Accepted:
July 7,
2016
Received:
July 5,
2016
Identification
Copyright
© 2016 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.
