It is well-known that serum ferritin levels increase as an acute phase reactant. In
patients who have infections or inflammatory states, the levels of ferritin can go
up several-fold. However, what has not been understood is why this phenomenon occurs,
if it has any physiological basis and if this evolutionary mechanism is of benefit
to the host?
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to European Journal of Internal MedicineAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Hepcidin and the iron-infection axis.Science. 2012; 338: 768-772
- Siderophore uptake in bacteria and the battle for iron with the host; a bird's eye view.Biometals. Aug 2010; 23: 601-611
- Iron availability increases the pathogenic potential of Salmonella typhimurium and other enteric pathogens at the intestinal epithelial interface.PLoS One. 2012; 7e29968
- Effects of routine prophylactic supplementation with iron and folic acid on admission to hospital and mortality in preschool children in a high malaria transmission setting: community-based, randomised, placebo-controlled trial.Lancet. Jan 14 2006; 367: 133-143
- Reduced risk for placental malaria in iron deficient women.Malar J. Feb 23 2011; 10: 47
- Effect of iron fortification on malaria incidence in infants and young children in Ghana: a randomized trial.JAMA. 2013; 310
- Effect of provision of daily zinc and iron with several micronutrients on growth and morbidity among young children in Pakistan: a cluster-randomised trial.Lancet. 2013 Jul 6; 382: 29-40
- Hepcidin and host defense against infectious diseases.PLoS Pathog. Aug 20 2015; 11e1004998
- Anemia of inflammation.Hematol Oncol Clin North Am. Aug 2014; 28: 671-678
- Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis.JAMA. Apr 2 2014; 311: 1317-1326
Article info
Publication history
Published online: August 01, 2016
Accepted:
July 20,
2016
Received:
July 18,
2016
Identification
Copyright
© 2016 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.
