- •The safety of anticoagulation in patients aged ≥100 years with VTE is uncertain.
- •Many patients had renal insufficiency or anemia, or were taking antiplatelets.
- •Most were treated at full therapeutic doses. Mean duration of therapy was 131 days.
- •The rate of VTE recurrences during therapy outweighed the rate of bleeds.
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- Antithrombotic therapy for VTE disease. Chest guideline and expert panel report.Chest. 2016; 149: 315-352
- Need for long-term anticoagulant treatment in symptomatic calf-vein thrombosis.Lancet. 1985; 515-518
- Warfarin sodium versus low-dose heparin in the long-term treatment of venous thrombosis.N Engl J Med. 1979; 301: 855-858
- Optimal duration of oral anticoagulant therapy: a randomized trial comparing four weeks with three months of warfarin in patients with proximal deep vein thrombosis.Thromb Haemost. 1995; 74: 606-611
- Extended low-intensity anticoagulation for thromboembolism investigators. Comparison of low-intensity warfarin therapy with conventional-intensity warfarin therapy for long-term prevention of recurrent venous thromboembolism.N Engl J Med. 2003; 349: 631-639
- PREVENT investigators. Long-term, low-intensity warfarin therapy for prevention of recurrent venous thromboembolism.N Engl J Med. 2003; 348: 1425-1434
- Deep-vein thrombosis in the elderly.Clin Appl Thromb Hemost. 2008; 14: 393-398
- Venous thromboembolism in the elderly. A community-based perspective.Thromb Haemost. 2008; 100: 780-788
- Low-molecular-weight heparin (enoxaparin) versus oral anticoagulant therapy (acenocoumarol) in the long-term treatment of deep venous thrombosis in the elderly: a randomized trial.Thromb Haemost. 2000; 84: 559-564
- Venous thromboembolism in very elderly patients: findings from a prospective registry (RIETE).Haematologica. 2006; 91: 1046-1051
- Venous thromboembolism in nonagenarians. Findings from the RIETE registry.Thromb Haemost. 2009; 101: 1112-1118
- Effects of age on the risk of dying from pulmonary embolism or bleeding during treatment of deep vein thrombosis.J Vasc Surg. 2011; 54: 26S-32S
- Clinical outcome of patients with venous thromboembolism and renal insufficiency. Findings from the RIETE registry.Thromb Haemost. 2007; 98: 771-776
- Predictive variables for major bleeding events in patients presenting with documented acute venous thromboembolism. Findings from the RIETE registry.Thromb Haemost. 2008; 100: 26-31
- Trends in the management and outcomes of acute pulmonary embolism: analysis from the RIETE registry.J Am Coll Cardiol. 2016; 67: 162-170
- Prediction of the risk of bleeding during anticoagulant treatment for venous thromboembolism.Arch Intern Med. 1999; 159: 457-460
- Development of a contemporary bleeding risk model for elderly warfarin recipients.Chest. 2006; 130: 1390-1396
- Clinical classification schemes for predicting hemorrhage: results from the National Registry of Atrial Fibrillation (NRAF).Am Heart J. 2006; 151: 713-719
- A novel user-friendly score (HAS-BLED) to assess 1-year risk of major bleeding in patients with atrial fibrillation: the Euro Heart Survey.Chest. 2010; 138: 1093-1100
- A new risk scheme to predict warfarin-associated hemorrhage: the ATRIA (Anticoagulation and Riskk Factors in Atrial Fibrillation) study.J Am Coll Cardiol. 2011; 58: 395-401
- Life tables for the United States Social Security Area, 1900–2100.Social Security Administration, Office of the Chief Actuary, Baltimore, MD2002
- Projections of the population by age and sex for the United States: 2010 to 2050 (NP2008-T12).Population Division, US Census Bureau, Washington, DC2008
- Centenarians: the older you get, the healthier you have been.Lancet. 1999; 354: 652
- Healthy centenarians do no exist, but autonomous centenarians do: a population-based study of morbidity among Danish centenarians.J Am Geriatr Soc. 2001; 49: 900-908
- Morbidity profiles of centenarians: survivors, delayers, and escapers.J Gerontol A Biol Sci Med Sci. 2003; 58: 232-237
- Social characteristics and health status of exceptionally long-lived Americans in the health and retirement study.J Am Geriatr Soc. 2011; 59: 2241-2248
- On behalf of the GUIDE-Care project. Place and cause of death in centenarians: a population-based observational study in England, 2001 to 2010.PLoS Med. 2014; 11e1001653
- Do centenarians die healthy? An autopsy study.J Gerontol. 2005; 60A: 862-865
- Hypercoagulability in centenarians: the paradox of successful aging.Blood. 1995; 85: 3144-3149