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Brain-kidney cross-talk: Definition and emerging evidence

Published:August 13, 2016DOI:https://doi.org/10.1016/j.ejim.2016.07.032

      Highlights

      • Both acute and chronic kidney diseases affect brain function.
      • Brain function affects kidney function.
      • The treatment of kidney disease may influence brain function.

      Abstract

      Cross-talk is broadly defined as endogenous homeostatic signaling between vital organs such as the heart, kidneys and brain. Kidney–brain cross-talk remains an area with excitingly few publications despite its purported clinical relevance in the management of currently undertreated conditions such as resistant hypertension. Therefore, this review aims to establish an organ-specific definition for kidney–brain cross-talk and review the available and forthcoming literature on this topic.

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