Advertisement

The efficacy and safety of selective granulocyte and monocyte apheresis for inflammatory bowel disease: A meta-analysis

  • Author Footnotes
    1 Department of Gastroenterology, The General Hospital of Jinan Military Command, 25 Shifan Road, Jinan 250031, Shandong, China.
    Zhenfei Liu
    Footnotes
    1 Department of Gastroenterology, The General Hospital of Jinan Military Command, 25 Shifan Road, Jinan 250031, Shandong, China.
    Affiliations
    Postgraduate Training Base of the General Hospital of Jinan Military Command of Jinzhou Medical University, Jinan, Shangdong, China
    Search for articles by this author
  • Xueliang Jiang
    Correspondence
    Corresponding author at: Department of Gastroenterology, The General Hospital of Jinan Military Command, 25 Shifan Road, Jinan 250031, China.
    Affiliations
    Department of Gastroenterology, The General Hospital of Jinan Military Command, Jinan, Shandong Province, China
    Search for articles by this author
  • Author Footnotes
    1 Department of Gastroenterology, The General Hospital of Jinan Military Command, 25 Shifan Road, Jinan 250031, Shandong, China.
    Chengcheng Sun
    Footnotes
    1 Department of Gastroenterology, The General Hospital of Jinan Military Command, 25 Shifan Road, Jinan 250031, Shandong, China.
    Affiliations
    Postgraduate Training Base of the General Hospital of Jinan Military Command of Jinzhou Medical University, Jinan, Shangdong, China
    Search for articles by this author
  • Author Footnotes
    1 Department of Gastroenterology, The General Hospital of Jinan Military Command, 25 Shifan Road, Jinan 250031, Shandong, China.
Published:September 07, 2016DOI:https://doi.org/10.1016/j.ejim.2016.08.028
      Selective granulocyte and monocyte apheresis (GMA) as a non-pharmacological option, has shown promising efficacy and higher safety in the treatment of patients with ulcerative colitis (UC). The GMA can not only promote healing of intestinal mucosa and improve the clinical remission rate, prolong the time of clinical alleviate [
      • Hanai H.
      • Iida T.
      • Takeuchi K.
      • Watanabe F.
      • Maruyama Y.
      • Kageoka M.
      • et al.
      Intensive granulocyte and monocyte adsorption versus intravenous prednisolone in patients with severe ulcerative colitis: an unblinded randomised multi-centre controlled study.
      ], to reduce the recurrence rate, but also have certain effect to control the extra-intestinal accompanying symptoms [
      • Ohno M.
      • Koyama S.
      • Ohara M.
      • Shimamoto K.
      • Kobayashi Y.
      • Nakamura F.
      • et al.
      Pyoderma gangrenosum with ulcerative colitis successfully treated by the combination of granulocyte and monocyte adsorption apheresis and corticosteroids.
      ,
      • Obayashi M.
      • Shimizu N.
      • Katube T.
      • Takano Y.
      • Kin H.
      • Nishimori T.
      • et al.
      Successful treatment for erythema nodosum and peripheral arthritis associated with ulcerative colitis by granulocyte and monocyte apheresis: a report of a case.
      ]. Compared with conventional therapy, GMA has shown promising efficacy and higher safety in the treatment of patients with ulcerative colitis (UC). However, the efficacy and safety in the Crohn's disease (CD) is controversial. Therefore, we report a meta-analysis of randomized trials assessing the efficacy and safety of GMA for inflammatory bowel disease (IBD).

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to European Journal of Internal Medicine
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Hanai H.
        • Iida T.
        • Takeuchi K.
        • Watanabe F.
        • Maruyama Y.
        • Kageoka M.
        • et al.
        Intensive granulocyte and monocyte adsorption versus intravenous prednisolone in patients with severe ulcerative colitis: an unblinded randomised multi-centre controlled study.
        Dig Liver Dis. 2008; 40: 433-440
        • Ohno M.
        • Koyama S.
        • Ohara M.
        • Shimamoto K.
        • Kobayashi Y.
        • Nakamura F.
        • et al.
        Pyoderma gangrenosum with ulcerative colitis successfully treated by the combination of granulocyte and monocyte adsorption apheresis and corticosteroids.
        Intern Med. 2016; 55: 25-30
        • Obayashi M.
        • Shimizu N.
        • Katube T.
        • Takano Y.
        • Kin H.
        • Nishimori T.
        • et al.
        Successful treatment for erythema nodosum and peripheral arthritis associated with ulcerative colitis by granulocyte and monocyte apheresis: a report of a case.
        Jpn J Gastroenterol. 2002; 99: 951-955
        • Zhu M.
        • Xu X.
        • Nie F.
        • Tong J.
        • Xiao S.
        • Ran Z.
        The efficacy and safety of selective leukocytapheresis in the treatment of ulcerative colitis: a meta-analysis.
        Int J Colorectal Dis. 2011; 26: 999-1007
        • Yoshino T.
        • Nakase H.
        • Minami N.
        • Yamada S.
        • Matsuura M.
        • Yazumi S.
        • et al.
        Efficacy and safety of granulocyte and monocyte adsorption apheresis for ulcerative colitis: a meta-analysis.
        Dig Liver Dis. 2013;
        • Fukunaga K.
        • Yokoyama Y.
        • Kamokozuru K.
        • Nagase K.
        • Nakamura S.
        • Miwa H.
        • et al.
        Adsorptive granulocyte/monocyte apheresis for the maintenance of remission in patients with ulcerative colitis: a prospective randomized, double blind, sham-controlled clinical trial.
        Gut Liver. 2012; 6: 427-433
        • Sakuraba A.
        • Sato T.
        • Morohoshi Y.
        • Matsuoka K.
        • Okamoto S.
        • Inoue N.
        • et al.
        Intermittent granulocyte and monocyte apheresis versus mercaptopurine for maintaining remission of ulcerative colitis: a pilot study.
        Ther Apher Dial. 2012; 16: 213-218
        • Sands B.E.
        • Katz S.
        • Wolf D.C.
        • Feagan B.G.
        • Wang T.
        • Gustofson L.M.
        • et al.
        A randomised, double-blind, sham-controlled study of granulocyte/monocyte apheresis for moderate to severe Crohn's disease.
        Gut. 2013; 62: 1288-1294
        • Kruis W.
        • Nguyen P.
        • Morgenstern J.
        Granulocyte/monocyte adsorptive apheresis in moderate to severe ulcerative colitis — effective or not?.
        Digestion. 2015; 92: 39-44
        • Yoshimura N.
        • Yokoyama Y.
        • Matsuoka K.
        • Takahashi H.
        • Iwakiri R.
        • Yamamoto T.
        • et al.
        An open-label prospective randomized multicenter study of intensive versus weekly granulocyte and monocyte apheresis in active crohn's disease.
        BMC Gastroenterol. 2015; 15
        • Ozeki K.
        • Tanida S.
        • Mizoshita T.
        • Tsukamoto H.
        • Ebi M.
        • Mori Y.
        • et al.
        Combination therapy with intensive granulocyte and monocyte adsorptive apheresis plus adalimumab: therapeutic outcomes in 5 cases with refractory Crohn's disease.
        Case Rep Gastroenterol. 2012; 6: 765-771