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Influence of thyroid volume on the effect of methimazole in Japanese subjects with mild Graves' disease

Published:September 03, 2016DOI:https://doi.org/10.1016/j.ejim.2016.08.030
      Methimazole (MMI) has been used in subjects with Graves' disease. Although in clinical medicine its starting dose was dependent on the judgment of each physician in charge, the Japan Thyroid Association treatment guidelines recommended that we should start MMI at a dose of 15 mg/day especially in subjects with mild Graves' disease with a baseline free T4 (FT4) levels between 0.24 pmol/L (1.9 ng/dL) and 0.64 pmol/L (5 ng/dL) from the viewpoint of preventing side effects [
      • The Japan Thyroid Association
      Medical guidelines for patients with Basedow disease.
      ,
      • The Japan Thyroid Association
      Reference of diagnosis of Basedow disease. Nankoudou, Tokyo.
      ]. Based on such background, in this study we examined which background factors influence on the effect of 15 mg/day of methimazole in Japanese subjects with mild Graves' disease.

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