Highlights
- •The overall incidence of PD was significantly higher in the AKI cohort with an adjusted HR of 1.47.
- •Compared with the non-AKI cohort aged ≤64, the relative risk of PD was 14.1 for the AKI cohort aged ≥80.
- •Patients with AKI were associated with a higher long-term risk of PD.
Abstract
Backgrounds
Worldwide, the incidence of acute kidney injury (AKI) has been increasing. However,
information on the long-term incidence of Parkinson disease (PD) in patients with
AKI has not been reported.
Methods
A total of 9380 patients with AKI and 37,484 age- and sex-matched patients who did
not have AKI were identified during 2003–2011. All patients were tracked until a diagnosis
of PD, death, or the end of 2011. Cumulative incidences and hazard ratios (HRs) were
calculated.
Results
The mean follow-up time for PD was 6.89 (SD = 3.30) years in the AKI cohort and 6.78 (SD = 3.29) years in the non-AKI cohort. The overall incidence densities of PD were significantly
higher in the AKI cohort than in the non-AKI cohort (6.04 vs. 3.99/1000 person-years),
with an adjusted HR of 1.47 (95% confidence interval [CI] = 1.18–1.83). Compared with the patients in the non-AKI cohort aged ≤64 years, the relative risk (95% CI) of PD was 2.17 (1.12–4.18), 14.1 (9.16–21.8), and
14.1 (8.43–23.6) for the patients in the AKI cohort aged ≤64, 65–79, and ≥80 years, respectively.
Conclusion
Patients with AKI were associated with a higher long-term risk of PD.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to European Journal of Internal MedicineAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Parkinson's disease: from monogenic forms to genetic susceptibility factors.Hum Mol Genet. 2009; 18: R48-R59
- The spectrum of nonmotor symptoms in early Parkinson disease.Neurology. 2013; 80: 276-281
- The CamPaIGN study of Parkinson's disease: 10-year outlook in an incident population-based cohort.J Neurol Neurosurg Psychiatry. 2013; 84: 1258-1264
- The coming acceleration of global population ageing.Nature. 2008; 451: 716-719
- Parkinson disease: from pathology to molecular disease mechanisms.Free Radic Biol Med. 2013; 62: 132-144
- Etiology and pathogenesis of Parkinson's disease.Mov Disord. 2011; 26: 1049-1055
- Risk of Parkinson disease onset in patients with diabetes a 9-year population-based cohort study with age and sex stratifications.Diabetes Care. 2012; 35: 1047-1049
- Heart rate variability and the risk of Parkinson disease: the atherosclerosis risk in communities study.Ann Neurol. 2015; 77: 877-883
- Increased risk of Parkinson's disease in patients with end-stage renal disease: a retrospective cohort study.Neuroepidemiology. 2014; 42: 204-210
- Antihypertensive agents and risk of Parkinson's disease: a nationwide cohort study.PLoS One. 2014; 9e98961
- Psychiatric diseases predated the occurrence of Parkinson disease: a retrospective cohort study.Ann Epidemiol. 2014; 24: 206-213
- Acute kidney injury, mortality, length of stay, and costs in hospitalized patients.J Am Soc Nephrol. 2005; 16: 3365-3370
- Acute kidney injury: an increasing global concern.Lancet. 2013; 382: 170-179
- Long-term risk of mortality and other adverse outcomes after acute kidney injury: a systematic review and meta-analysis.Am J Kidney Dis. 2009; 53: 961-973
- Associations between acute kidney injury and cardiovascular and renal outcomes after coronary angiography.Circulation. 2011; 123: 409-416
- Acute kidney injury leads to inflammation and functional changes in the brain.J Am Soc Nephrol. 2008; 19: 1360-1370
- The impact of acute kidney injury on the long-term risk of stroke.J Am Heart Assoc. 2014; 3
- Pyogenic liver abscess is associated with increased risk of acute kidney injury: a Nationwide population-based cohort study.Medicine. 2016; 95e2489
- Risk of developing severe sepsis after acute kidney injury: a population-based cohort study.Crit Care. 2013; 17: R231
- Increased risk of Parkinson disease in patients with carbon monoxide intoxication: a population-based cohort study.Medicine. 2015; 94e869
- Risk of Parkinson's disease following zolpidem use: a retrospective, population-based cohort study.J Clin Psychiatry. 2015; 76: e104-e110
- Background.in: Secondary background. 2015
- Bidirectional association between asthma and irritable bowel syndrome: two population-based retrospective cohort studies.PLoS One. 2016; 11e0153911
- Association between kidney stones and risk of stroke: a nationwide population-based cohort study.Medicine. 2016; 95e2847
- Febrile convulsions increase risk of Tourette syndrome.Seizure. 2014; 23: 651-656
- Oxidative stress is increased in critically ill patients with acute renal failure.J Am Soc Nephrol. 2004; 15: 2449-2456
- Changes in metabolic profiles during acute kidney injury and recovery following ischemia/reperfusion.PLoS One. 2014; 9e106647
- Serum metabolomic profiles from patients with acute kidney injury: a pilot study.J Chromatogr B Analyt Technol Biomed Life Sci. 2012; 893–894: 107-113
- The local and systemic inflammatory transcriptome after acute kidney injury.J Am Soc Nephrol. 2008; 19: 547-558
- Parkinson's—divergent causes, convergent mechanisms.Science. 2004; 304: 1120-1122
- Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases.Nature. 2006; 443: 787-795
- Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease.Nature. 1988; 334: 345-348
- Environmental risk factors and Parkinson's disease: selective degeneration of nigral dopaminergic neurons caused by the herbicide paraquat.Neurobiol Dis. 2002; 10: 119-127
- Ageing and Parkinson's disease: why is advancing age the biggest risk factor?.Ageing Res Rev. 2014; 14: 19-30
- Pharmacological treatment of parkinson disease: a review.JAMA. 2014; 311: 1670-1683
- Chronic kidney disease after acute kidney injury: a systematic review and meta-analysis.Kidney Int. 2012; 81: 442-448
- Genetic and environmental factors in the cause of Parkinson's disease.Ann Neurol. 2003; 53: S16-S25
Article info
Publication history
Published online: October 01, 2016
Accepted:
September 18,
2016
Received in revised form:
August 24,
2016
Received:
August 1,
2016
Identification
Copyright
© 2016 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.
