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Association between acute kidney injury and risk of Parkinson disease

  • Shih-Yi Lin
    Affiliations
    Graduate Institute of Clinical Medical Science, College of Medicine, China Medical University, Taichung, Taiwan

    Division of Nephrology and Kidney Institute, China Medical University Hospital, Taichung, Taiwan
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  • Cheng-Li Lin
    Affiliations
    Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan

    College of Medicine, China Medical University, Taichung, Taiwan
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  • Wu-Huei Hsu
    Affiliations
    Graduate Institute of Clinical Medical Science, College of Medicine, China Medical University, Taichung, Taiwan

    Division of Pulmonary and Critical Care Medicine, China Medical University Hospital and China Medical University, Taichung, Taiwan
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  • Hung-Chieh Yeh
    Affiliations
    Graduate Institute of Clinical Medical Science, College of Medicine, China Medical University, Taichung, Taiwan

    Division of Nephrology and Kidney Institute, China Medical University Hospital, Taichung, Taiwan
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  • Cheng-Chieh Lin
    Affiliations
    Graduate Institute of Clinical Medical Science, College of Medicine, China Medical University, Taichung, Taiwan

    Department of Family Medicine, China Medical University Hospital, Taichung, Taiwan
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  • Chih-Hsueh Lin
    Affiliations
    Graduate Institute of Clinical Medical Science, College of Medicine, China Medical University, Taichung, Taiwan

    Department of Family Medicine, China Medical University Hospital, Taichung, Taiwan
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  • Chun-Hung Tseng
    Correspondence
    Corresponding author at: Graduate Institute of Clinical Medical Science and School of Medicine, College of Medicine, China Medical University, No. 2, Yuh-Der Road, Taichung 404, Taiwan.
    Affiliations
    Graduate Institute of Clinical Medical Science, College of Medicine, China Medical University, Taichung, Taiwan

    Department of Neurology, China Medical University Hospital, Taichung, Taiwan
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Published:October 01, 2016DOI:https://doi.org/10.1016/j.ejim.2016.09.016

      Highlights

      • The overall incidence of PD was significantly higher in the AKI cohort with an adjusted HR of 1.47.
      • Compared with the non-AKI cohort aged ≤64, the relative risk of PD was 14.1 for the AKI cohort aged ≥80.
      • Patients with AKI were associated with a higher long-term risk of PD.

      Abstract

      Backgrounds

      Worldwide, the incidence of acute kidney injury (AKI) has been increasing. However, information on the long-term incidence of Parkinson disease (PD) in patients with AKI has not been reported.

      Methods

      A total of 9380 patients with AKI and 37,484 age- and sex-matched patients who did not have AKI were identified during 2003–2011. All patients were tracked until a diagnosis of PD, death, or the end of 2011. Cumulative incidences and hazard ratios (HRs) were calculated.

      Results

      The mean follow-up time for PD was 6.89 (SD = 3.30) years in the AKI cohort and 6.78 (SD = 3.29) years in the non-AKI cohort. The overall incidence densities of PD were significantly higher in the AKI cohort than in the non-AKI cohort (6.04 vs. 3.99/1000 person-years), with an adjusted HR of 1.47 (95% confidence interval [CI] = 1.18–1.83). Compared with the patients in the non-AKI cohort aged ≤64 years, the relative risk (95% CI) of PD was 2.17 (1.12–4.18), 14.1 (9.16–21.8), and 14.1 (8.43–23.6) for the patients in the AKI cohort aged ≤64, 65–79, and ≥80 years, respectively.

      Conclusion

      Patients with AKI were associated with a higher long-term risk of PD.

      Keywords

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