Statins constitute the major class of cholesterol-lowering drugs and 10–15% reported
Statin induced myalgia [
[1]
]. Randomized controlled trials report that alternate day or once a week dosing of
long acting statins (atorvastatin and rosuvastatin) minimized the incidence of myalgia.
In the absence of a systematic review or a quantitative meta-analysis on the same,
the present review was conducted.Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to European Journal of Internal MedicineAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- The broad spectrum of statin myopathy: from myalgia torhabdomyolysis.Curr. Opin. Lipidol. 2007; 18: 401-408
- Efficacy of alternate day dosing of atorvastatin.J Chin Clin Med. 2007; 2: 547-551
- Efficacy of alternate-day dosing versus daily dosing of atorvastatin.J. Cardiovasc. Pharmacol. Ther. 2003; 8: 123-126
- Does alternate day dosing of statin suffice? A comparative study of O.D to A/D dosing of atorvastatin on hypercholesterolemia.Journal of Advance Researchers in Biol Sci. 2013; 5: 23-24
- Alternate day versus once daily atorvastatin for primary prevention of CHD in naïve patients of dyslipidemia.J. Clin. Diagn. Res. 2014; 8: 27-31
- Efficacy of alternate-day versus everyday dosing of atorvastatin.Indian J. Pharm. 2012; 44: 362-365
- The comparison of the effects of standard 20 mg atorvastatin daily and 20 mg atorvastatin every other day on serum LDL-cholesterol and high sensitive C-reactive protein levels.Anadolu Kardiyol Derg. 2008; 8: 407-412
- Is alternate daily dose of atorvastatin effective in treating patients with hyperlipidemia? The alternate day versus daily dosing of atorvastatin study (ADDAS).Am. Heart J. 2002; 144: 674-677
- Alternate-day versus daily atorvastatin in coronary artery disease: a randomized study.Anadolu Kardiyol Derg. 2012; 12: 90-96
- Comparison of alternate-day atorvastatin treatment to daily treatment in maintaining LDL-cholesterol targets in patients with variable coronary risk profile.J. Cardiovasc. Pharmacol. 2012; 59: 479-484
- A comparative evaluation of efficacy and safety of daily dosing versus alternate day dosing of rosuvastatin for dyslipidemic patients.Int J Med Dent Sci. 2013; 2: 111-120
- Impact of 10 mg rosuvastatin daily or alternate-day on lipid profile and inflammatory markers.Clin. Chim. Acta. 2012; 413: 139-142
- Efficacy of alternate day versus daily dosing of rosuvastatin.Can J Cardiol. 2009; 25: e28-e31
- Comparative long-term efficacy and tolerability of pitavastatin 4 mg and atorvastatin 20-40 mg in patients with type 2 diabetes mellitus and combined (mixed) dyslipidemia.Diabetes Obes. Metab. 2011; 13: 1047-1055
- United States Food and Drug Administration briefing document for the endocrinologic and metabolic drugs advisory committee 2013.(Available at) ([Accessed on 02 Feb 2016])
Article info
Publication history
Published online: January 04, 2017
Accepted:
December 16,
2016
Received in revised form:
December 12,
2016
Received:
December 6,
2016
Identification
Copyright
© 2017 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.