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The longitudinal relationship between six-minute walk test and cardiopulmonary exercise testing, and association with symptoms in systolic heart failure: Analysis from the ESCAPE trial

Published:January 05, 2017DOI:https://doi.org/10.1016/j.ejim.2016.12.017
      The six-minute walk test (6MWT) and cardiopulmonary exercise testing (CPET) are two objective modalities utilized for examining the functional status in patients with heart failure (HF). CPET reproducibly determines maximum exercise capacity through measurements of peak oxygen uptake (peak VO2) and other ventilatory variables, and was shown to provide additional prognostic information that prioritize patients for heart transplantation (HT) and mechanical circulatory support, and predicts mortality [
      • Mancini D.M.
      • et al.
      Value of peak exercise oxygen consumption for optimal timing of cardiac transplantation in ambulatory patients with heart failure.
      ]. The 6MWT is used as an alternative to CPET to evaluate the functional capacity in HF because of ease of its implementation and good tolerability, and has thus been considered a submaximal exercise test [
      • Zugck C.
      • et al.
      Is the 6-minute walk test a reliable substitute for peak oxygen uptake in patients with dilated cardiomyopathy?.
      ,
      • Guazzi M.
      • et al.
      Six-minute walk test and cardiopulmonary exercise testing in patients with chronic heart failure: a comparative analysis on clinical and prognostic insights.
      ]. Prior studies demonstrated the relationship between 6MWT and peak VO2 in HF [
      • Zugck C.
      • et al.
      Is the 6-minute walk test a reliable substitute for peak oxygen uptake in patients with dilated cardiomyopathy?.
      ,
      • Carvalho E.E.
      • et al.
      Heart failure: comparison between six-minute walk test and cardiopulmonary test.
      ]. We aim to investigate the longitudinal relationship between distance walked (6MWD) and CPET-derived variables in patients with acute systolic HF, and to examine the association between HF symptoms and both tests.

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      References

        • Mancini D.M.
        • et al.
        Value of peak exercise oxygen consumption for optimal timing of cardiac transplantation in ambulatory patients with heart failure.
        Circulation. 1991; 83: 778-786
        • Zugck C.
        • et al.
        Is the 6-minute walk test a reliable substitute for peak oxygen uptake in patients with dilated cardiomyopathy?.
        Eur Heart J. 2000; 21: 540-549
        • Guazzi M.
        • et al.
        Six-minute walk test and cardiopulmonary exercise testing in patients with chronic heart failure: a comparative analysis on clinical and prognostic insights.
        Circ Heart Fail. 2009; 2: 549-555
        • Carvalho E.E.
        • et al.
        Heart failure: comparison between six-minute walk test and cardiopulmonary test.
        Arq Bras Cardiol. 2011; 97: 59-64
        • Binanay C.
        • et al.
        Evaluation study of congestive heart failure and pulmonary artery catheterization effectiveness: the ESCAPE trial.
        JAMA. 2005; 294: 1625-1633
        • Lipkin D.P.
        • et al.
        Six minute walking test for assessing exercise capacity in chronic heart failure.
        Br Med J (Clin Res Ed). 1986; 292: 653-655
        • Guglin M.
        • Patel T.
        • Darbinyan N.
        Symptoms in heart failure correlate poorly with objective haemodynamic parameters.
        Int J Clin Pract. 2012; 66: 1224-1229
        • Evangelista L.S.
        • et al.
        Correlates of fatigue in patients with heart failure.
        Prog Cardiovasc Nurs. 2008; 23: 12-17
        • Perez-Moreno A.C.
        • et al.
        Fatigue as a predictor of outcome in patients with heart failure: analysis of CORONA (Controlled Rosuvastatin Multinational Trial in Heart Failure).
        JACC Heart Fail. 2014; 2: 187-197
        • Chase P.J.
        • et al.
        Effects of respiratory exchange ratio on the prognostic value of peak oxygen consumption and ventilatory efficiency in patients with systolic heart failure.
        JACC Heart Fail. 2013; 1: 427-432