Whereas ongoing oral anticoagulation (OAC), with either warfarin or a non-vitamin
K-antagonist oral anticoagulant (NOAC), should generally be confirmed in patients
with atrial fibrillation (AF) who undergo percutaneous coronary intervention with
stent (PCI-S) [
1
,
2
], the type (i.e., warfarin versus NOAC) and dose (i.e., standard versus reduced) of
the oral anticoagulant to be added to dual anti platelet therapy of aspirin and clopidogrel
(DAPT) when AF develops early after PCI-S need necessarily to be chosen.To read this article in full you will need to make a payment
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References
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- The optimal management of patients on oral anticoagulation undergoing coronary artery stenting. The 10th anniversary overview.Thromb Haemost. 2014; 112: 1080-1087
- New-onset atrial fibrillation after recent coronary stenting: warfarin or non-vitamin K-antagonist oral anticoagulant to be added to aspirin and clopidogrel? A viewpoint.Int J Cardiol. 2015; 96: 133-138
- Reduced dose and reduced exposure to non-vitamin K-antagonist oral anticoagulants: some considerations on this relationship.Int J Cardiol. 2016; 223: 519-520
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- Effects of renal impairment on the pharmacokinetics, pharmacodynamics and safety of rivaroxaban, an oral, direct factor Xa inhibitor.Br J Clin Pharmacol. 2010; 70: 703-712
- Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events (ACTIVE W): a randomized controlled trial.Lancet. 2006; 367: 1903-1912
- The effect of dabigatran plasma concentrations and patient characteristics on the frequency of ischemic stroke and major bleeding in atrial fibrillation patients. The RE-LY trial (Randomized Evaluation of Long-term anticoagulation therapy).J Am Coll Cardiol. 2014; 63: 321-328
- Association between edoxaban dose, concentration, anti-factor Xa activity, and outcomes: an analysis of data from the randomised, double-blind ENGAGE AF-TIMI 48 trial.Lancet. 2015; 385: 2288-2295
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Article info
Publication history
Published online: January 10, 2017
Accepted:
January 4,
2017
Received:
December 27,
2016
Identification
Copyright
© 2017 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.
