Several studies conclude that patients with inflammatory bowel disease (IBD) are at
an increased risk of osteoporosis (30–50%) [
[1]
] and fractures (1.3 to 2.5 times) [
[2]
]. Different factors can be implicated (intestinal malabsorption, hypogonadism, physical
inactivity, use of corticoids and deficiency of vitamin D) [
3
,
4
]. Moreover, the increase of proinflammatory cytokines, such as the tumor necrosis
factor (TNF) and the interleukins (IL), also appear to be involved in the pathogenesis
of bone loss in these patients [
[5]
]. Although anti-TNF drugs are frequently used in patients with IBD, their influence
on bone metabolism in these patients is not well known. The objective of this study
was to prospectively assess the effect of TNF blockade on bone metabolism and bone
mineral density (BMD).To read this article in full you will need to make a payment
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References
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- Combination therapy with an immunomodulator and anti-TNFα agent improves bone mineral density in IBD patients.J Crohn's Colitis. 2014; 8: 1693-1701
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- Association of vitamin D level with clinical status in inflammatory bowel disease: a 5-year.Am J Gastroenterol. 2016; 111: 712-719
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Article info
Publication history
Published online: February 04, 2017
Accepted:
January 30,
2017
Received in revised form:
January 25,
2017
Received:
December 2,
2016
Identification
Copyright
© 2017 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.
