Disorders of glucose metabolism are highly prevalent among patients with established
cerebrovascular disease. Up to 60% to 70% of patients may have dysglycemic state [
[1]
]. However, to date, insufficient evidence is available to show that stroke recurrence
prevention will be improved by intensive glucose-lowering treatment in people with
diabetes or related disorders. Moreover, no hypoglycemic drug has been proven to reduce
subsequent strokes [
- Kernan W.N.
- Ovbiagele B.
- Black H.R.
- Bravata D.M.
- Chimowitz M.I.
- Ezekowitz M.D.
- et al.
American Heart Association Stroke Council, Council on Cardiovascular and Stroke Nursing,
Council on Clinical Cardiology, and Council on Peripheral Vascular Disease. Guidelines
for the prevention of stroke in patients with stroke and transient ischemic attack:
a guideline for healthcare professionals from the American Heart Association/American
Stroke Association.
Stroke. 2014; 45: 2160-2236
[1]
].- Kernan W.N.
- Ovbiagele B.
- Black H.R.
- Bravata D.M.
- Chimowitz M.I.
- Ezekowitz M.D.
- et al.
American Heart Association Stroke Council, Council on Cardiovascular and Stroke Nursing,
Council on Clinical Cardiology, and Council on Peripheral Vascular Disease. Guidelines
for the prevention of stroke in patients with stroke and transient ischemic attack:
a guideline for healthcare professionals from the American Heart Association/American
Stroke Association.
Stroke. 2014; 45: 2160-2236
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References
- American Heart Association Stroke Council, Council on Cardiovascular and Stroke Nursing, Council on Clinical Cardiology, and Council on Peripheral Vascular Disease. Guidelines for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline for healthcare professionals from the American Heart Association/American Stroke Association.Stroke. 2014; 45: 2160-2236
- Pleiotropic effects of thiazolidinediones: implications for the treatment of patients with type 2 diabetes mellitus.Hosp. Pract. (1995). 2013; 41: 132-147
- Effects of pioglitazone in patients with type 2 diabetes with or without previous stroke: results from PROactive (PROspective pioglitAzone Clinical Trial In macroVascular Events 04).Stroke. 2007; 38: 865-873
- Peroxisome proliferator-activated receptor gamma agonists for preventing recurrent stroke and other vascular events in patients with stroke or transient ischaemic attack.Cochrane Database Syst. Rev. 2015; 10CD010693
- IRIS Trial Investigators. Pioglitazone after ischemic stroke or transient ischemic attack.N Engl J Med. 2016; 374: 1321-1331
- Pioglitazone for secondary stroke prevention: a systematic review and meta-analysis.Stroke. 2017; 48: 388-393
Article info
Publication history
Published online: February 13, 2017
Accepted:
February 9,
2017
Received:
February 7,
2017
Identification
Copyright
© 2017 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.
