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Pioglitazone: Good news for diabetic patients with stroke?

Published:February 13, 2017DOI:https://doi.org/10.1016/j.ejim.2017.02.005
      Disorders of glucose metabolism are highly prevalent among patients with established cerebrovascular disease. Up to 60% to 70% of patients may have dysglycemic state [
      • Kernan W.N.
      • Ovbiagele B.
      • Black H.R.
      • Bravata D.M.
      • Chimowitz M.I.
      • Ezekowitz M.D.
      • et al.
      American Heart Association Stroke Council, Council on Cardiovascular and Stroke Nursing, Council on Clinical Cardiology, and Council on Peripheral Vascular Disease. Guidelines for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline for healthcare professionals from the American Heart Association/American Stroke Association.
      ]. However, to date, insufficient evidence is available to show that stroke recurrence prevention will be improved by intensive glucose-lowering treatment in people with diabetes or related disorders. Moreover, no hypoglycemic drug has been proven to reduce subsequent strokes [
      • Kernan W.N.
      • Ovbiagele B.
      • Black H.R.
      • Bravata D.M.
      • Chimowitz M.I.
      • Ezekowitz M.D.
      • et al.
      American Heart Association Stroke Council, Council on Cardiovascular and Stroke Nursing, Council on Clinical Cardiology, and Council on Peripheral Vascular Disease. Guidelines for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline for healthcare professionals from the American Heart Association/American Stroke Association.
      ].
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