We thank Martinez-Tellez and co-authors for their interest in our article. Martinez-Tellez
et al. are quite right in their statement that there are more factors involved in
activation of human BAT than we described in our article [
[1]
. However, the main aim of our manuscript was to speculate on/discuss the potential
influence of facial cooling in the activation of BAT and therefore we did not focus
on other differences between the publication of Admiraal et al. and Bakker et al.
[
2
,
3
.To read this article in full you will need to make a payment
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References
- Hot heads & cool bodies: the conundrums of human brown adipose tissue (BAT) activity research.Eur J Intern Med. 2017;
- Cold-induced activity of brown adipose tissue in young lean men of South-Asian and European origin.Diabetologia. 2013;
- Brown adipose tissue volume in healthy lean South Asian adults compared with white Caucasians: a prospective, case-controlled observational study.Lancet Diabetes Endocrinol. 2014; 2: 210-217
- Interobserver and intraobserver variability for the assessment of brown adipose tissue activity on 18F-FDG PET-CT.Nucl Med Commun. 2016; 37: 363-371
- Seasonal influence on stimulated BAT activity in prospective trials: a retrospective analysis of BAT visualized on 18F-FDG PET-CTs and 123I-mIBG SPECT-CTs.J Appl Physiol. 2016; 120: 1418-1423
- Brown adipose tissue is involved in the seasonal variation of cold-induced thermogenesis in humans.Am J Phys Regul Integr Comp Phys. 2016; ajpregu.00057.2015
Article info
Publication history
Published online: March 07, 2017
Accepted:
March 2,
2017
Received:
February 28,
2017
Identification
Copyright
© 2017 Published by Elsevier B.V. on behalf of European Federation of Internal Medicine.
ScienceDirect
Access this article on ScienceDirectLinked Article
- Hot heads & cool bodies: The conundrums of human brown adipose tissue (BAT) activity researchEuropean Journal of Internal MedicineVol. 40
- PreviewBrown adipose tissue is able to increase energy expenditure by converting glucose and fatty acids into heat. Therefore, BAT is able to increase energy expenditure and could thereby facilitate weight loss or at least weight maintenance. Since cold is a strong activator of BAT, most prospective research is performed during cold to activate BAT. In current research, there are roughly two methods of cooling. Cooling by lowering ambient air temperature, which uses a fixed temperature for all subjects and personalized cooling, which uses cooling blankets or vests with temperatures that can be adjusted to the individual set point of shivering.
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- Activation and quantification of human brown adipose tissue: Methodological considerations for between studies comparisons: Comment on: Hot heads & cool bodies: The conundrums of human BAT activity researchEuropean Journal of Internal MedicineVol. 40
- PreviewWe read with interest the study by Bahler et al. [1] that discusses the findings observed in two studies comparing brown adipose tissue (BAT) activity and volume in healthy young white Caucasians and South Asians [2,3]. While Admiraal et al. [2] found no differences in BAT activity and volume between groups, Bakker et al. [3] reported lower BAT volume in South Asians, despite the fact that both studies were comparable in terms of age, body mass index, sex, ethnicity and country of the participants.
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